Nature or Nurture – Will Epigenomics Solve the Dilemma?

1. Akbarian, S., Halene, T. The neuroepigenetics of suicide. The American Journal of Psychiatry 170(5), 2013, pp. 462-465.10.1176/appi.ajp.2013.13020235405556723632831Search in Google Scholar

2. Aksoy-Aksel, A., Zampa, F., Schratt, G. MicroRNAs and synaptic plasticity--a mutual relationship. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0515414203625135976Search in Google Scholar

3. Alexander, R. P., Fang, G., Rozowsky, J., Snyder, M., Gerstein, M. B. Annotating non-coding regions of the genome. Nature Reviews. Genetics 11(8), 2010, pp. 559-571.10.1038/nrg281420628352Search in Google Scholar

4. Anthoni, H., Zucchelli, M., Matsson, H., Müller-Myhsok, B., Fransson, I., Schumacher, J., Massinen, S., Onkamo, P., Warnke, A., Griesemann, H., Hoffmann, P., Nopola-Hemmi, J., Lyytinen, H., Schulte-Körne, G., Kere, J., Nöthen, M. M., Peyrard-Janvid, M. A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. Human Molecular Genetics 16(6), 2007, pp. 667-677.10.1093/hmg/ddm00917309879Search in Google Scholar

5. Anway, M. D., Cupp, A. S., Uzumcu, M., Skinner, M. K. Epigenetic trans-generational actions of endocrine disruptors and male fertility. Science 308, 2005, pp. 1466-1469.10.1126/science.110819015933200Search in Google Scholar

6. Arai, J. A., Li, S., Hartley, D. M., Feig, L. A. Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment. Journal of Neuroscience 29, 2009, pp. 1496-1502.10.1523/JNEUROSCI.5057-08.2009340823519193896Search in Google Scholar

7. Bale, T. L. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues in Clinical Neuroscience 16(3), 2014, pp. 297-305.10.31887/DCNS.2014.16.3/tbaleSearch in Google Scholar

8. Barker, D., Barker, M., Fleming, T., Lampl, M. Developmental biology: Support mothers to secure future public health. Nature 504(7479), 2013, pp. 209-211.Search in Google Scholar

9. Barry, G. Lamarckian evolution explains human brain evolution and psychiatric disorders. Frontiers in Neuroscience 7, 2013, pp. 224.10.3389/fnins.2013.00224384050424324395Search in Google Scholar

10. Berger, S., Pérez-Rodríguez, P., Veturi, Y., Simianer, H., de los Campos, G.. Effectiveness of shrinkage and variable selection methods for the prediction of complex human traits using data from distantly related individuals. Annals of Human Genetics 79(2), 2015, pp. 122-135.10.1111/ahg.12099442815525600682Search in Google Scholar

11. Bersaglieri, T., Sabeti, P. C., Patterson, N., Vanderploeg, T., Schaffner, S. F., Drake, J. A., Rhodes, M., Reich, D. E., Hirschhorn, J. N. Genetic signatures of strong recent positive selection at the lactase gene. American Journal of Human Genetics 74(6), 2004, pp. 1111-1120.10.1086/421051118207515114531Search in Google Scholar

12. Blaxter, M. Genetics. Revealing the dark matter of the genome. Science 330(6012), 2010, pp. 1758-1759.Search in Google Scholar

13. Bohacek, J., Gapp, K., Saab, B. J., Mansuy, I. M. Transgenerational epigenetic effects on brain functions. Biological Psychiatry 73(4), 2013, pp. 313-320.10.1016/j.biopsych.2012.08.01923062885Search in Google Scholar

14. Bowers, M. E., Yehuda, R. Intergenerational transmission of stress in humans. Neuropsychopharmacology 41(1), 2016, pp. 232-244.10.1038/npp.2015.247467713826279078Search in Google Scholar

15. Bromer, J. G., Wu, J., Zhou, Y., Taylor, H. S. Hypermethylation of Homeobox A10 by in utero diethylstilbestrol exposure: An epigenetic mechanism for altered developmental programming. Endocrinology 150, 2009, pp. 3376-3382.10.1210/en.2009-0071270350819299448Search in Google Scholar

16. Burggren, W. W. Epigenetics as a source of variation in comparative animal physiology - or - Lamarck is lookin' pretty good these days. The Journal of Experimental Biology 217(Pt 5), 2014, pp. 682-689.10.1242/jeb.08613224574384Search in Google Scholar

17. Burggren, W. W., Crews, D. Epigenetics in comparative biology: why we should pay attention. Integrative and Comparative Biology 54(1), 2014, pp. 7-20.10.1093/icb/icu013413357224722321Search in Google Scholar

18. Button, T. M., Lau, J. Y., Maughan, B., Eley, T. C. Parental punitive discipline, negative life events and gene-environment interplay in the development of externalizing behavior. Psychological Medicine 38(1), 2008, pp. 29-39.10.1017/S0033291707001328290639817803832Search in Google Scholar

19. Cacabelos, R., Torrellas C. Epigenetics of aging and Alzheimer's disease: Implications for pharmacogenomics and drug response. International Journal of Molecular Sciences 16(12), 2015, pp. 30483-30543.10.3390/ijms161226236469117726703582Search in Google Scholar

20. Cao-Lei, L., Elgbeili, G., Massart, R., Laplante, D. P., Szyf, M., King, S. Pregnant women's cognitive appraisal of a natural disaster affects DNA methylation in their children 13 years later: Project Ice Storm. Translational Psychiatry 5, 2015, p. e515.10.1038/tp.2015.13444575025710121Search in Google Scholar

21. Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Shaw, N., Lane, C. R., Lim, E. P., Kalyanaraman, N., Nemesh, J., Ziaugra, L., Friedland, L., Rolfe, A., Warrington, J., Lipshutz, R., Daley, G. Q., Lander, E. S. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature Genetics 22(3), 1999, pp. 231-238. Erratum in: Nature Genetics 23(3), 1999, p. 373.10.1038/1029010391209Search in Google Scholar

22. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., Poulton, R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 2003, pp. 386-389.10.1126/science.108396812869766Search in Google Scholar

23. Chabris, C. F., Hebert, B. M., Benjamin, D. J., Beauchamp, J., Cesarini, D., van der Loos, M., Johannesson, M., Magnusson, P. K., Lichtenstein, P., Atwood, C. S., Freese, J., Hauser, T. S., Hauser, R. M., Christakis, N., Laibson, D. Most reported genetic associations with general intelligence are probably false positives. Psychological Science 23(11), 2012, pp. 1314-23.10.1177/0956797611435528349858523012269Search in Google Scholar

24. Chen, C., Meng, S. Q., Xue, Y. X., Han, Y., Sun, C. Y., Deng, J. H., Chen, N., Bao, Y. P., Zhang, F. L., Cao, L. L., Zhu, W. G., Shi, J., Song, W. H., Lu, L. Epigenetic modification of PKMζ rescues aging-related cognitive impairment. Scientific Reports 6, 2016, p. 22096.10.1038/srep22096477200326926225Search in Google Scholar

25. Chong, S., Whitelaw, E. Epigenetic germline inheritance. Current Opinion in Genetics & Development 14, 2004, pp. 692-696.10.1016/j.gde.2004.09.00115531166Search in Google Scholar

26. Clarke, A.J., Cooper, D.N., GWAS: heritability missing in action? European Journal of Human Genetics 18, 2010, pp. 859-861.10.1038/ejhg.2010.35298738920234388Search in Google Scholar

27. Conrad, D. F., Pinto, D., Redon, R., Feuk, L., Gokcumen, O., Zhang, Y., Aerts, J., Andrews, T. D., Barnes, C., Campbell, P., Fitzgerald, T., Hu, M., Ihm, C. H., Kristiansson, K., Macarthur, D. G., Macdonald, J. R., Onyiah, I., Pang, A. W., Robson, S., Stirrups, K., Valsesia, A., Walter, K., Wei, J., Wellcome Trust Case Control Consortium, Tyler-Smith, C., Carter, N. P., Lee, C., Scherer, S. W., Hurles, M. E. Origins and functional impact of copy number variation in the human genome. Nature 464(7289), 2010, pp. 704-712.Search in Google Scholar

28. Cortés-Mendoza, J., Díaz de León-Guerrero, S., Pedraza-Alva, G., Pérez-Martínez, L. Shaping synaptic plasticity: the role of activity-mediated epigenetic regulation on gene transcription. International Journal of Developmental Neuroscience 31(6), 2013, pp. 359-69.10.1016/j.ijdevneu.2013.04.00323665156Search in Google Scholar

29. Crews, D., Gillette, R., Scarpino, S. V., Manikkam, M., Savenkova, M. I., Skinner, M. K. Epigenetic transgenerational inheritance of altered stress responses. Proceedings of the National Academy of Sciences of the United States of America 109, 2012, pp. 9143-9148. 10.1073/pnas.1118514109338416322615374Search in Google Scholar

30. Curley, J. P., Champagne, F.A. Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods. Frontiers in Neuroendocrinology 40, 2016, pp. 52-66.10.1016/j.yfrne.2015.11.001478328426616341Search in Google Scholar

31. Dawson, M. A., Kouzarides, T. Cancer epigenetics: from mechanism to therapy. Cell 150(1), 2012, pp. 12-27.10.1016/j.cell.2012.06.01322770212Search in Google Scholar

32. Daxinger, L., Whitelaw, E. Transgenerational epigenetic inheritance: More questions than answers. Genome Research 20, 2010, pp. 1623-1628.10.1101/gr.106138.110298998821041414Search in Google Scholar

33. Daxinger, L., Whitelaw, E. Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nature Reviews Genetics 13, 2012, pp. 153-162.10.1038/nrg318822290458Search in Google Scholar

34. de los Campos, G., Vazquez, A. I., Fernando, R., Klimentidis, Y. C., Sorensen, D. Prediction of complex human traits using the genomic best linear unbiased predictor. PLoS Genetics 9(7), 2013, p. e1003608.10.1371/journal.pgen.1003608370884023874214Search in Google Scholar

35. Desrivières, S., Lourdusamy, A., Tao, C., Toro, R., Jia, T., Loth, E., Medina, L. M., Kepa, A., Fernandes, A., Ruggeri, B., Carvalho, F. M., Cocks, G., Banaschewski, T., Barker, G. J., Bokde, A. L., Büchel, C., Conrod, P. J., Flor, H., Heinz, A., Gallinat, J., Garavan, H., Gowland, P., Brühl, R., Lawrence, C., Mann, K., Martinot, M. L., Nees, F., Lathrop, M., Poline, J. B., Rietschel, M., Thompson, P., Fauth-Bühler, M., Smolka, M. N., Pausova, Z., Paus, T., Feng, J., Schumann, G. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Molecular Psychiatry 20(2), 2014, pp. 263-274.10.1038/mp.2013.197405159224514566Search in Google Scholar

36. Devanna, P., Middelbeek, J., Vernes, S. C. FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways. Frontiers in Cellular Neuroscience 8, 2014, p. 305.10.3389/fncel.2014.00305417645725309332Search in Google Scholar

37. Dias, B. G., Maddox, S. A., Klengel, T., Ressler, K. J. Epigenetic mechanisms underlying learning and the inheritance of learned behaviors. Trends in Neuroscience 38(2), 2015, pp. 96-107.10.1016/j.tins.2014.12.003432386525544352Search in Google Scholar

38. Dias, B. G., Ressler, K. J. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience 17(1), 2014, pp. 89-96.10.1038/nn.3594392383524292232Search in Google Scholar

39. Dick, D. M., Agrawal, A., Keller, M. C., Adkins, A., Aliev, F., Monroe, S., Hewitt, J. K., Kendler, K. S., Sher, K. J. Candidate gene-environment interaction research: reflections and recommendations. Perspectives on Psychological Science: A Journal of the Association for Psychological Science 10(1), 2015, pp. 37-59.Search in Google Scholar

40. Dick, D. M., Bernard, M., Aliev, F., Viken, R., Pulkkinen, L., Kaprio, J., Rose, R. J. The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use. Alcoholism: Clinical and Experimental Research 33(10), 2009, pp. 1739-1748.10.1111/j.1530-0277.2009.01011.x359484619624574Search in Google Scholar

41. Dietz, D. M., LaPlant, Q., Watts, E. L., Hodes, G. E., Russo, S. J., Feng, J., Oosting, R. S., Vialou, V., Nestler, E. J. Paternal transmission of stress-induced pathologies. Biological Psychiatry 70, 2011, pp. 408-414.10.1016/j.biopsych.2011.05.005321719721679926Search in Google Scholar

42. Drong, A. W., Lindgren, C. M., McCarthy, M. I. The genetic and epigenetic basis of type 2 diabetes and obesity. Clinical Pharmacology and Therapeutics 92(6), 2012, pp. 707-15.10.1038/clpt.2012.149711674723047653Search in Google Scholar

43. Duncan, L. E., Keller, M. C. A critical review of the first 10 years of candidate gene-byenvironment interaction research in psychiatry. American Journal of Psychiatry 168, 2011, pp. 1041-1049.10.1176/appi.ajp.2011.11020191322223421890791Search in Google Scholar

44. Egger, G., Liang, G., Aparicio, A., Jones, P. A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429(6990), 2004, pp. 457-463.Search in Google Scholar

45. Ehrlich, M., Lacey, M. DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics 5, 2013, pp. 553-568.10.2217/epi.13.43386489824059801Search in Google Scholar

46. Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., Järvelä, I. Identification of a variant associated with adult-type hypolactasia. Nature Genetics 30(2), 2002, pp. 233-237.10.1038/ng82611788828Search in Google Scholar

47. Enattah, N. S., Jensen, T. G., Nielsen, M., Lewinski, R., Kuokkanen, M., Rasinpera, H., El- Shanti, H., Seo, J. K., Alifrangis, M., Khalil, I. F., Natah, A., Ali, A., Natah, S., Comas, D., Mehdi, S. Q., Groop, L., Vestergaard, E. M., Imtiaz, F., Rashed, M. S., Meyer, B., Troelsen, J., Peltonen, L. Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. American Journal of Human Genetics 82(1), 2008, pp. 57-72.10.1016/j.ajhg.2007.09.012225396218179885Search in Google Scholar

48. English, A. C., Salerno, W. J., Hampton, O. A., Gonzaga-Jauregui, C., Ambreth, S., Ritter, D. I., Beck, C. R., Davis, C. F., Dahdouli, M., Ma, S., Carroll, A., Veeraraghavan, N., Bruestle, J., Drees, B., Hastie, A., Lam, E. T., White, S., Mishra, P., Wang, M., Han, Y., Zhang, F., Stankiewicz, P., Wheeler, D. A., Reid, J. G., Muzny, D. M., Rogers, J., Sabo, A., Worley, K. C., Lupski, J. R., Boerwinkle, E., Gibbs, R. A. Assessing structural variation in a personal genome-towards a human reference diploid genome. BMC Genomics 16, 2015, p. 286.10.1186/s12864-015-1479-3449061425886820Search in Google Scholar

49. Fagiolini, M., Jensen, C. L., Champagne, F. A. Epigenetic influences on brain development and plasticity. Current Opinion in Neurobiology 19(2), 2009, pp. 207-212.10.1016/j.conb.2009.05.009274559719545993Search in Google Scholar

50. Fass, D. M., Schroeder, F. A., Perlis, R. H., Haggarty, S. J. Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience 264, 2014, pp. 112-130.10.1016/j.neuroscience.2013.01.041383072123376737Search in Google Scholar

51. Federman, N., Zalcman, G., de la Fuente, V., Fustiñana, M. S., Romano, A. Epigenetic mechanisms and memory strength: a comparative study. Journal of Physiology, Paris 108(4-6), 2014, pp. 278-85.10.1016/j.jphysparis.2014.06.00324978317Search in Google Scholar

52. Feil, R., Fraga, M. Epigenetics and the environment: Emerging patterns and implications. Nature Review Genetics 13(2), 2012, pp. 97-109.10.1038/nrg314222215131Search in Google Scholar

53. Feuk, L., Carson, A. R., Scherer, S. W. Structural variation in the human genome. Nature Reviews. Genetics 7(2), 2006, pp. 85-97.10.1038/nrg176716418744Search in Google Scholar

54. Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., Tsai, L. H. Recovery of learning and memory is associated with chromatin remodeling. Nature 447(7141), 2007, pp. 178-82.Search in Google Scholar

55. Fisher, S.E. Tangled webs: tracing the connections between genes and cognition. Cognition. 101(2), 2006, pp. 270-97.10.1016/j.cognition.2006.04.00416764847Search in Google Scholar

56. Fisher, S. E., Scharff, C. FOXP2 as a molecular window into speech and language. Trends in Genetics 25, 2009, pp. 166-177.10.1016/j.tig.2009.03.00219304338Search in Google Scholar

57. Fisher, S. E., Vargha-Khadem, F., Watkins, K. E., Monaco, A. P., Pembrey, M. E. Localisation of a gene implicated in a severe speech and language disorder. Nature Genetics 18(2), 1998, pp. 168-170.10.1038/ng0298-1689462748Search in Google Scholar

58. Flynn, J. R. The mean IQ of Americans: Massive gains 1932 to 1978. Psychological Bulletin 95, 1984, pp. 29-51.10.1037/0033-2909.95.1.29Search in Google Scholar

59. Fox-Keller, E. The mirage of a space between nature and nurture. Duke University Press: Durham, NC and London, 2010.10.1515/9780822392811Search in Google Scholar

60. Fraga, M. F., Ballesta, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., Boix-Chornet, M., Sanchez-Aguilera, A., Ling, C., Carlsson, E., Poulsen, P., Vaag, A., Stephan, Z., Spector, T. D., Wu, Y. Z., Plass, C., Esteller, M. Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences of the United States of America 102(30), 2005, pp. 10604-10609.10.1073/pnas.0500398102117491916009939Search in Google Scholar

61. Franklin, T. B., Russig, H., Weiss, I. C., Graff, J., Linder, N., Michalon, A. Epigenetic transmission of the impact of early stress across generations. Biological Psychiatry 68, 2010, pp. 408-415.10.1016/j.biopsych.2010.05.03620673872Search in Google Scholar

62. Fu, L., Shi, Z., Luo, G., Tu, W., Wang, X., Fang, Z., Li, X. Multiple microRNAs regulate human FOXP2 gene expression by targeting sequences in its 3' untranslated region. Molecular Brain 7, 2014, p. 71.10.1186/s13041-014-0071-0418959125269856Search in Google Scholar

63. Fullard, J. F., Halene, T. B., Giambartolomei, C., Haroutunian, V., Akbarian, S., Roussos, P. Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophrenia Research Jan 27, 2016, pp. S0920-9964(16)30039-1.10.1016/j.schres.2016.01.039496330626827128Search in Google Scholar

64. Galton, F. On men of science, their nature and nurture. In. Notices of the proceedings at the meetings of the members of the Royal Institution of Great Britain. Vol. VII. 1873-1875, William Clowes and Sons: London, 1875. Search in Google Scholar

65. Gamazon, E. R., Stranger, B. E. The impact of human copy number variation on gene expression. Briefings in Functional Genomics 14(5), 2015, pp. 352-357.10.1093/bfgp/elv017459235425922366Search in Google Scholar

66. Gao, M. C., Bellugi, U., Dai, L., Mills, D. L., Sobel, E. M., Lange, K., Korenberg, J. R. Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex. PLoS ONE 5(4), 2010, p. e10292.10.1371/journal.pone.0010292285821220422020Search in Google Scholar

67. Gapp, K., Bohacek, J., Grossmann, J., Brunner, A. M., Manuella, F., Nanni, P., Mansuy, I. M. Potential of environmental enrichment to prevent transgenerational effects of paternal trauma. Neuropsychopharmacology Jun 9, 2016.10.1038/npp.2016.87502674427277118Search in Google Scholar

68. Gerstein, M. B., Bruce, C., Rozowsky, J. S., Zheng, D., Du, J., Korbel, J. O., Emanuelsson, O., Zhang, Z. D., Weissman, S., Snyder M. What is a gene, post-ENCODE? History and updated definition. Genome Research 17(6), 2007, pp. 669-681.10.1101/gr.633960717567988Search in Google Scholar

69. Glinsky, G. V. Phenotype-defining functions of multiple non-coding RNA pathways. Cell Cycle 7(11), 2008, pp. 1630-1639.10.4161/cc.7.11.597618469518Search in Google Scholar

70. Gluckman, P. D., Hanson M. A. The fetal matrix: Evolution, development, and disease. Cambridge University Press: New York, 2005.Search in Google Scholar

71. Gräff, J., Mansuy, I. M. Epigenetic codes in cognition and behavior. Behavioural Brain Research 192(1), 2008, pp. 70-87.10.1016/j.bbr.2008.01.02118353453Search in Google Scholar

72. Gravlee, C. C. How race becomes biology: Embodiment of social inequality. American Journal of Physical Anthropology 139, 2009, pp. 47-57.10.1002/ajpa.2098319226645Search in Google Scholar

73. Greiffenstein, M. F. Secular IQ increases by epigenesis? The hypothesis of cognitive genotype optimization. Psychological Reports 109(2), 2011, pp. 353-366.10.2466/03.04.10.19.PR0.109.5.353-36622238843Search in Google Scholar

74. Griffiths, B. B., Hunter, R. G. Neuroepigenetics of stress. Neuroscience 275, 2014, pp. 420-435.10.1016/j.neuroscience.2014.06.04124976514Search in Google Scholar

75. Grossniklaus, U., Kelly, W. G., Ferguson-Smith, A. C., Pembrey, M., Lindquist, S. Transgenerational epigenetic inheritance: How important is it? Nature Reviews Genetics 14(11), 2013, pp. 228-235.10.1038/nrg3435406684723416892Search in Google Scholar

76. Gudbjartsson, D. F., Walters, G. B., Thorleifsson, G., Stefansson, H., Halldorsson, B. V., Zusmanovich, P., Sulem, P., Thorlacius, S., Gylfason, A., Steinberg, S., Helgadottir, A., Ingason, A., Steinthorsdottir, V., Olafsdottir, E. J., Olafsdottir, G. H., Jonsson, T., Borch-Johnsen, K., Hansen, T., Andersen, G., Jorgensen, T., Pedersen, O., Aben, K. K., Witjes, J. A., Swinkels, D. W., den Heijer, M., Franke, B., Verbeek, A. L., Becker, D. M., Yanek, L. R., Becker, L. C., Tryggvadottir, L., Rafnar, T., Gulcher, J., Kiemeney, L. A., Kong, A., Thorsteinsdottir, U., Stefansson, K. Many sequence variants affecting diversity of adult human height. Nature Genetics 40, 2008, pp. 609-615.10.1038/ng.12218391951Search in Google Scholar

77. Gupta-Agarwal, S., Jarome, T. J., Fernandez, J., Lubin, F. D. NMDA receptor- and ERKdependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation. Learning & Memory 21(7), 2014, pp. 351-362.10.1101/lm.035105.114406142624939839Search in Google Scholar

78. Hamatani, T. Human spermatozoal RNAs. Fertility and Sterility 97, 2012, pp. 275-281.10.1016/j.fertnstert.2011.12.03522289287Search in Google Scholar

79. Haraksingh, R. R., Snyder, M. P. Impacts of variation in the human genome on gene regulation. Journal of Molecular Biology 425(21), 2013, pp. 3970-3977.10.1016/j.jmb.2013.07.01523871684Search in Google Scholar

80. Harden, K. P., Hill, J. E., Turkheimer, E., Emery, R. E. Gene-environment correlation and interaction in peer effects on adolescent alcohol and tobacco use. Behavior Genetics 38, 2008, pp. 339-347.10.1007/s10519-008-9202-7289855818368474Search in Google Scholar

81. Heard, E., Martienssen, R. A. Transgenerational Epigenetic Inheritance: Myths and Mechanisms. Cell 157, 2014, pp. 95-109.10.1016/j.cell.2014.02.045402000424679529Search in Google Scholar

82. Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., Lumey, L. H. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proceedings of the National Academy of Sciences USA 105, 2008, pp. 17046-17049.10.1073/pnas.0806560105257937518955703Search in Google Scholar

83. Heinzelmann, M., Gill, J. Epigenetic mechanisms shape the biological response to trauma and risk for PTSD: A critical review. Nursing Research and Practice 2013, 2013, p. 417010. 10.1155/2013/417010365433223710355Search in Google Scholar

84. Hiemstra, M., Kleinjan, M., van Schayck, O. C., Engels, R. C., Otten, R. Environmental smoking and smoking onset in adolescence: the role of dopamine-related genes. Findings from two longitudinal studies. PLoS One 9(1), 2014, p. e86497.10.1371/journal.pone.0086497389772924466121Search in Google Scholar

85. Hindorff, L. A, Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., Manolio, T. A. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proceedings of the National Academy of Sciences of the United States of America 106(23), 2009, pp. 9362-9367.10.1073/pnas.0903103106268714719474294Search in Google Scholar

86. Imamura, T., Uesaka, M., Nakashima, K. Epigenetic setting and reprogramming for neural cell fate determination and differentiation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0511414203225135972Search in Google Scholar

87. Jablonka, E. Epigenetic variations in heredity and evolution. Clinical Pharmacology and Therapeutics 92(6), 2012, pp. 683-688.10.1038/clpt.2012.15823073209Search in Google Scholar

88. Jablonka, J., Raz, G. Transgenerational epigenetic inheritance: Prevalence, mechanisms, and implications for the study of heredity and evolution. Quarterly Review of Biology 84, 2009, pp. 131-176.10.1086/59882219606595Search in Google Scholar

89. Jarome, T. J., Butler, A. A., Nichols, J. N., Pacheco, N. L., Lubin, F. D. NF-κB mediates Gadd45β expression and DNA demethylation in the hippocampus during fear memory formation. Frontiers in Molecular Neuroscience 8, 2015, pp. 54.10.3389/fnmol.2015.00054458495626441517Search in Google Scholar

90. Jarome, T. J., Thomas, J. S., Lubin, F. D. The epigenetic basis of memory formation and storage. Progress in Molecular Biology and Translational Science 28, 2014, pp. 1-27.10.1016/B978-0-12-800977-2.00001-225410539Search in Google Scholar

91. Jia, Y., Chen, L., Ma, Y., Zhang, J., Xu, N., Liao, D.J. To know how a gene works, we need to redefine it first but then, more importantly, to let the cell itself decide how to transcribe and process its RNAs. International Journal of Biological Sciences 11(12), 2015, pp. 1413-1423.10.7150/ijbs.13436467199926681921Search in Google Scholar

92. Jirtle, R. L., Skinner, M. K. Environmental epigenomics and disease susceptibility. Nature Reviews Genetics 8, pp. 253-262.10.1038/nrg2045594001017363974Search in Google Scholar

93. Johnson, G. D., Lalancette, C., Linnemann, A. K., Leduc, F., Boissonneault, G., Krawetz, S. A. The sperm nucleus: Chromatin, RNA, and the nuclear matrix. Reproduction 141, 2011, pp. 21-36.10.1530/REP-10-0322535866920876223Search in Google Scholar

94. Kaati, G., Bygren, L. O., Pembrey, M., Sjostrom, M. Transgenerational response to nutrition, early life circumstances and longevity. European Journal of Human Genetics 15(7), pp. 784-790.10.1038/sj.ejhg.520183217457370Search in Google Scholar

95. Kahrer-Sawatzki, H. What a difference copy number variation makes. Bioessays 29(4), 2007, pp. 311-313.10.1002/bies.2055417373652Search in Google Scholar

96. Kellermann, N. P. Epigenetic transmission of holocaust trauma: can nightmares be inherited? The Israel Journal of Psychiatry and Related Sciences 50(1), 2013, pp. 33-39.Search in Google Scholar

97. Keverne, E. B., Curley, J. P. Epigenetics, brain evolution and behavior. Frontiers in Neuroendocrinology 29(3), 2008, pp. 398-412.10.1016/j.yfrne.2008.03.00118439660Search in Google Scholar

98. Kevles, D. J. In the name of eugenics: Genetics and the uses of human heredity. Harvard University Press: Cambridge, MA, 1985.Search in Google Scholar

99. Kim, D. H., Saetrom, P., Snove, O., Jr., Rossi, J. J. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 105, 2-8, pp. 16230-16235.10.1073/pnas.0808830105257102018852463Search in Google Scholar

100. Kingsley, D. M. From atoms to traits. Scientific American 300(1), 2009, pp. 52-59.10.1038/scientificamerican0109-5219186749Search in Google Scholar

101. Krawetz, S. A. Paternal contribution: New insights and future challenges. Nature Reviews Genetics 6, 2005, pp. 633-642.10.1038/nrg165416136654Search in Google Scholar

102. Krawetz, S. A., Kruger, A., Lalancette, C., Tagett, R., Anton, E., Draghici, S., et al. A survey of small RNAs in human sperm. Human Reproduction 26, 2011, pp. 3401-3412.10.1093/humrep/der329321287921989093Search in Google Scholar

103. Kubota ,T., Mochizuki, K. Epigenetic effect of environmental factors on autism spectrum disorders. International Journal of Environmental Research and Public Health 13(5), 2016, p. E504.10.3390/ijerph13050504488112927187441Search in Google Scholar

104. Kuokkanen, M., Kokkonen, J., Enattah, N. S., Ylisaukko-oja, T., Komu, H., Varilo, T., Peltonen, L., Savilahti, E., Jarvela, I. Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. American Journal of Human Genetics 78(2), 2006, pp. 339-344.10.1086/500053138024016400612Search in Google Scholar

105. Kuzawa, C., Sweet, E. Epigenetics and the embodiment of race: Developmental origins of US racial disparities in cardiovascular health. American Journal of Human Biology 21, 2009, pp. 2-15.10.1002/ajhb.2082218925573Search in Google Scholar

106. Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M. J., Turecki, G. Genome-wide epigenetic regulation by earlylife trauma. Archives of General Psychiatry 69(7), 2012, pp. 722-731.10.1001/archgenpsychiatry.2011.2287499194422752237Search in Google Scholar

107. Lander, E. S. Initial impact of the sequencing of the human genome. Nature 470(7333), 2011, pp. 187-197.Search in Google Scholar

108. Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., Funke, R., Gage, D., Harris, K., Heaford, A., Howland, J., Kann, L., Lehoczky, J., LeVine, R., McEwan, P., McKernan, K., Meldrim, J., Mesirov, J. P., Miranda, C., Morris, W., Naylor, J., Raymond, C., Rosetti, M., Santos, R., Sheridan, A., Sougnez, C., Stange-Thomann, Y., Stojanovic, N., Subramanian, A., Wyman, D., Rogers, J., Sulston, J., Ainscough, R., Beck, S., Bentley, D., Burton, J., Clee, C., Carter, N., Szustakowki, J., et al., International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409(6822), 2001, pp. 860-921. Erratum in: Nature 411(6838), 2001, pp. 720. Szustakowki, J. [corrected to Szustakowski, J]. Nature 412(6846), 2001, p. 565.Search in Google Scholar

109. Leen-Feldner, E. W., Feldner, M. T., Knapp, A,, Bunaciu, L., Blumenthal, H., Amstadter, A.B. Offspring psychological and biological correlates of parental posttraumatic stress: review of the literature and research agenda. Clinical Psychology Review 33(8), 2013, pp. 1106-1133.10.1016/j.cpr.2013.09.00124100080Search in Google Scholar

110. Lettre, G., Jackson, A. U., Gieger, C., Schumacher, F. R., Berndt, S. I., Sanna, S., Eyheramendy, S., Voight, B. F., Butler, J. L., Guiducci, C., Illig, T., Hackett, R., Heid, I. M., Jacobs, K. B., Lyssenko, V., Uda, M., et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nature Genetics 40, 2008, pp. 584-591.10.1038/ng.125268707618391950Search in Google Scholar

111. Levy, Y., Ebstein, R. P. Research review: crossing syndrome boundaries in the search for brain endophenotypes. Journal of Child Psychology and Psychiatry, and Allied Disciplines 50(6), 2009, pp. 657-668.10.1111/j.1469-7610.2008.01986.x19175806Search in Google Scholar

112. Liebers, R., Rassoulzadegan, M., Lyko, F. Epigenetic regulation by heritable RNA. PLoS Genetics 10(4), 2014, p. e1004296.10.1371/journal.pgen.1004296399047724743450Search in Google Scholar

113. Liegeois, F., Baldeweg, T., Connelly, A., Gadian, D. G., Mishkin, M., Vargha-Khadem, F. Language fMRI abnormalities associated with FOXP2 gene mutation. Nature Neuroscience 6(11), 2003, pp. 1230-1237.10.1038/nn1138Search in Google Scholar

114. Lim, J. P., Brunet, A. Bridging the transgenerational gap with epigenetic memory. Trends in Genetics 29(3), 2013, pp. 176-186.10.1016/j.tig.2012.12.008Search in Google Scholar

115. Liu, N., Pan, T. RNA epigenetics. Translational Research: The Journal of Laboratory and Clinical Medicine 165(1), 2015, pp. 28-35.10.1016/j.trsl.2014.04.003Search in Google Scholar

116. Lock, M. The epigenome and nature/nurture reunification: a challenge for anthropology. Medical Anthropology 32(4), 2013, pp. 291-308.10.1080/01459740.2012.746973Search in Google Scholar

117. Locke, J. Some Thoughts Concerning Education: Full and Fine 1693 Edition (Illustrated) Kindle Edition. www.WealthOfNation.com, 2014.10.1093/oseo/instance.00016977Search in Google Scholar

118. Maccari, S., Krugers, H. J., Morley-Fletcher, S., Szyf, M., Brunton, P. J. The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. Journal of Neuroendocrinology 26(10), 2014, pp. 707-723.10.1111/jne.12175Search in Google Scholar

119. Maher, B. Personal genomes: The case of the missing heritability. Nature 456(7218), 2008, pp. 18-21.Search in Google Scholar

120. Makowsky, R., Pajewski, N. M., Klimentidis, Y. C., Vazquez, A. I., Duarte, C. W., Allison, D. B., de los Campos, G. Beyond Missing Heritability: Prediction of Complex Traits. PLoS Genetics 7, 2011, p. e1002051. 10.1371/journal.pgen.1002051Search in Google Scholar

121. Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., Cho, J. H., Guttmacher, A. E., Kong, A., Kruglyak, L., Mardis, E., Rotimi, C. N., Slatkin, M., Valle, D., Whittemore, A. S., Boehnke, M., Clark, A. G., Eichler, E. E., Gibson, G., Haines, J. L., Mackay, T.F., McCarroll, S. A., Visscher, P. M. Finding the missing heritability of complex diseases. Nature 461, 2009, pp. 747-753.10.1038/nature08494Search in Google Scholar

122. Mansuy, I. M., Mohanna, S. Epigenetics and the human brain: where nurture meets nature. Cerebrum 2011 May, 2011, p. 8.Search in Google Scholar

123. Marcus, G. F., Fisher, S. E. FOXP2 in focus: what can genes tell us about speech and language? Trends in Cognitive Science 7(6), 2003, pp. 257-262.10.1016/S1364-6613(03)00104-9Search in Google Scholar

124. Marian, A. J. Molecular genetic studies of complex phenotypes. Translational Research: The Journal of Laboratory and Clinical Medicine 159(2), 2012, pp. 64-79.10.1016/j.trsl.2011.08.001325953022243791Search in Google Scholar

125. Marino, C., Mascheretti, S., Riva, V., Cattaneo, F., Rigoletto, C., Rusconi, M., Gruen, J. R., Giorda, R., Lazazzera, C., Molteni, M. Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia. Behavior Genetics 41(1), 2011, pp. 67-76.10.1007/s10519-010-9412-7393967621046216Search in Google Scholar

126. Mascheretti, S., Riva, V., Giorda, R., Beri, S., Lanzoni, L. F., Cellino, M. R., Marino, C. KIAA0319 and ROBO1: evidence on association with reading and pleiotropic effects on language and mathematics abilities in developmental dyslexia. Journal of Human Genetics 59(4), 2014, pp. 189-197.10.1038/jhg.2013.14124430574Search in Google Scholar

127. McGowan, P. O., Szyf, M. The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiology of Disease 39(1), 2010, pp. 66-72.10.1016/j.nbd.2009.12.02620053376Search in Google Scholar

128. Meloni, M., Testa, G. Scrutinizing the epigenetics revolution. Biosocieties 9(4), 2014, pp. 431-456.10.1057/biosoc.2014.22425506625484911Search in Google Scholar

129. Miller, G. The seductive allure of behavioral epigenetics. Science 329, 2010, pp. 24-27.10.1126/science.329.5987.2420595592Search in Google Scholar

130. Mitchell, E., Klein, S. L., Argyropoulos, K. V., Sharma, A., Chan, R. B., Toth, J. G., Barboza, L., Bavley, C., Bortolozzi, A., Chen, Q., Liu, B., Ingenito, J., Mark, W., Dudakov, J., Gross, S., Di Paolo, G., Artigas, F., van den Brink, M., Toth, M. Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nature Communications 7, 2016, p. 11492.10.1038/ncomms11492486917627173585Search in Google Scholar

131. Monsey, M. S., Ota, K. T., Akingbade, I. F., Hong, E. S., Schafe, G. E. Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdale. PLoS One 6(5), 2011, p. e19958.10.1371/journal.pone.0019958309885621625500Search in Google Scholar

132. Morris, K. V. Chan, S.W.-L., Jacobsen, S.E., Looney, D.J. Small interfering RNA-induced transcriptional gene silencing in human cells. Science 305, 2004, pp. 1289-1292.10.1126/science.110137215297624Search in Google Scholar

133. Mozzi, A., Forni, D., Clerici, M., Pozzoli, U., Mascheretti, S., Guerini, F. R., Riva, S., Bresolin, N., Cagliani, R., Sironi, M. The evolutionary history of genes involved in spoken and written language: beyond FOXP2. Scientific Reports 6, 2016, p. 22157.10.1038/srep22157476644326912479Search in Google Scholar

134. Mukamel, Z., Konopka, G., Wexler, E., Osborn, G. E., Dong, H., Bergman, M. Y., Levitt, P., Geschwind, D. H. Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk. Journal of Neuroscience 31(32), 2011, pp. 11437-11442.10.1523/JNEUROSCI.0181-11.2011366761021832174Search in Google Scholar

135. Nagy, C., Turecki, G. Transgenerational epigenetic inheritance: an open discussion. Epigenomics 7(5), 2015, pp. 781-790.10.2217/epi.15.4626344807Search in Google Scholar

136. Naumova, O. Y., Lee, M., Koposov, R., Szyf, M., Dozier, M., Grigorenko, E. L. Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents”, Development and Psychopathology 24(1), 2012, 143-155.10.1017/S0954579411000605347085322123582Search in Google Scholar

137. Nestler, E. J. Transgenerational epigenetic contributions to stress responses: fact or fiction? PLoS Biology 14(3), 2016, p. e1002426 (Correction: PLoS Biology 14(6), 2016, p. e1002486).Search in Google Scholar

138. Newbury, D. F., Winchester, L., Addis, L., Paracchini, S., Buckingham, L. L., Clark, A., Cohen, W., Cowie, H., Dworzynski, K., Everitt, A., Goodyer, I. M., Hennessy, E., Kindley, A. D., Miller, L. L., Nasir, J., O'Hare, A., Shaw, D., Simkin, Z., Simonoff, E., Slonims, V., Watson, J., Ragoussis, J., Fisher, S. E., Seckl, J. R., Helms, P. J., Bolton, P. F., Pickles, A., Conti-Ramsden, G., Baird, G., Bishop, D. V., Monaco, A. P. CMIP and ATP2C2 modulate phonological short-term memory in language impairment. American Journal of Human Genetics 85(2), 2009, pp. 264-272.10.1016/j.ajhg.2009.07.004272523619646677Search in Google Scholar

139. Nilsson, E. E., Skinner, M. K. Environmentally induced epigenetic transgenerational inheritance of disease susceptibility. Translational Research: The Journal of Laboratory and Clinical Medicine 165(1), 2015, pp. 12-17.10.1016/j.trsl.2014.02.003414847124657180Search in Google Scholar

140. Olfson, E., Edenberg, H. J., Nurnberger, J., Jr., Agrawal, A., Bucholz, K. K., Almasy, L. A., Chorlian, D., Dick, D. M., Hesselbrock, V. M., Kramer, J. R., Kuperman, S., Porjesz, B., Schuckit, M. A., Tischfield, J. A., Wang, J. C., Wetherill, L., Foroud, T. M., Rice, J., Goate, A., Bierut, L. J. An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. Alcoholism: Clinical and Experimental Research 38(10), 2014, pp. 2541-2549.Search in Google Scholar

141. Painter, R., Osmond, C., Gluckman, P., Hanson, M., Phillips, D., Roseboom, T. J. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG: An International Journal of Obstetrics and Gynaecology 115, 2008, pp. 1243-1249.10.1111/j.1471-0528.2008.01822.x18715409Search in Google Scholar

142. Paracchini, S. Dissection of genetic associations with language-related traits in populationbased cohorts. Journal of Neurodevelopmental Disorders 3, 2011, pp. 365-373.10.1007/s11689-011-9091-6323076321894572Search in Google Scholar

143. Pearson, H. Genetics: what is a gene? Nature 441(7092), 2006, pp. 398-401.Search in Google Scholar

144. Peixoto, L., Abel, T. The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology 38(1), 2013, pp. 62-76.10.1038/npp.2012.86352199422669172Search in Google Scholar

145. Pennisi, E. Genomics. ENCODE project writes eulogy for junk DNA. Science 337(6099), pp. 1159-1161.Search in Google Scholar

146. Perera, F., Herbstman, J. Prenatal environmental exposures, epigenetics, and disease. Reproductive Toxicology 31(3), 2011, pp. 363-373.10.1016/j.reprotox.2010.12.055317116921256208Search in Google Scholar

147. Perroud, N., Rutembesa, E., Paoloni-Giacobino, A., Mutabaruka, J., Mutesa, L., Stenz, L., et al. The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis. The World Journal of Biological Psychiatry: the Official Journal of the World Federation of Societies of Biological Psychiatry 15(4), 2014, pp. 334-345.Search in Google Scholar

148. Perry, G. H., Dominy, N. J., Claw, K. G., Lee, A. S., Fiegler, H., Redon, R., Werner, J., Villanea, F. A., Mountain, J. L., Misra, R., Carter, N. P., Lee, C., Stone, A. C. Diet and the evolution of human amylase gene copy number variation. Nature Genetics 39(10), 2007, pp. 1256-1260.10.1038/ng2123237701517828263Search in Google Scholar

149. Pietschnig, .J, Voracek, M., Formann, A. K. Pervasiveness of the IQ rise: a cross-temporal meta-analysis. PLoS One 5(12), 2010, p. e14406.10.1371/journal.pone.0014406300867321203545Search in Google Scholar

150. Plomin, R., DeFries, J. C., Knopik, V. S., Neiderhiser, J. M. Top 10 replicated findings from behavioral genetics. Perspectives on Psychological Science 11, 2016, pp. 3-23.10.1177/1745691615617439Search in Google Scholar

151. Plomin, R., DeFries, J. C., McClearn, G. E., McGuffin, P. Behavioral genetics. Worth Publishers: New York, 2001.Search in Google Scholar

152. Plomin, R., Kovas, Y. Generalist genes and learning disabilities. Psychological Bulletin 131, 2005, pp. 592-617.10.1037/0033-2909.131.4.592Search in Google Scholar

153. Przeworski, M., Hudson, R. R., Di Rienzo, A. Adjusting the focus on human variation. Trends in Genetics 16(7), 2000, pp. 296-302.10.1016/S0168-9525(00)02030-8Search in Google Scholar

154. Qureshi, I. A., Mehler, M. F. An evolving view of epigenetic complexity in the brain. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0506414202725135967Search in Google Scholar

155. Radtke, K. M., Ruf, M., Gunter, H. M., Dohrmann, K., Schauer, M., Meyer, A., Elbert, T. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry 1, 2011, p. e21. 10.1038/tp.2011.21330951622832523Search in Google Scholar

156. Radtke, K. M., Schauer, M., Gunter, H. M., Ruf-Leuschner, M., Sill, J., Meyer, A., Elbert, T. Epigenetic modifications of the glucocorticoid receptor gene are associated with the vulnerability to psychopathology in childhood maltreatment. Translational Psychiatry 5, 2015, p. e571.10.1038/tp.2015.63447129426080088Search in Google Scholar

157. Reich, D. E., Schaffner, S. F., Daly, M. J., McVean, G., Mullikin, J. C., Higgins, J. M., Richter, D. J., Lander, E. S., Altshuler, D. Human genome sequence variation and the influence of gene history, mutation and recombination. Nature Genetics 32(1), 2002, pp. 135-142.10.1038/ng94712161752Search in Google Scholar

158. Richards, E. J. Inherited epigenetic variation - revisiting soft inheritance. Nature Reviews Genetics 7, 2006, pp. 395-401.10.1038/nrg183416534512Search in Google Scholar

159. Richardson, Sarah S. Maternal bodies in the postgenomic order: Gender and the explanatory landscape of epigenetics. In. Richardson S. S., Stevens H. (eds.). Postgenomics: Perspectives on biology after the genome. Duke University Press, 2015Search in Google Scholar

160. Richardson, Sarah S., Daniels, C. R., Gillman, M. W., Golden, J., Kukla, R., Kuzawa, Ch., Rich-Edwards, J. Don’t blame the mothers. Nature 512, 2014, pp. 131-132.10.1038/512131a25119222Search in Google Scholar

161. Rietveld, C. A., Esko, T., Davies, G., Pers, T. H., Turley, P., Benyamin, B., Chabris, C. F., Emilsson, V., Johnson, A. D., Lee, J. J., de Leeuw, C., Marioni, R. E., Medland, S. E., Miller, M. B., Rostapshova, O., van der Lee, S. J., Vinkhuyzen, A. A., Amin, N., Conley, D., Derringer, J., van Duijn, C. M., Fehrmann, R., Franke, L., Glaeser, E. L., et al. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proceedings of the National Academy of Sciences of the United States of America 111(38), 2014, pp. 13790-13794.10.1073/pnas.1404623111418331325201988Search in Google Scholar

162. Rivera, C. M., Ren, B. Mapping human epigenomes. Cell 155, 2013, pp. 39-55.10.1016/j.cell.2013.09.011383889824074860Search in Google Scholar

163. Roberts, T. C., Morris, K. V., Wood, M. J. The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0507414202825135968Search in Google Scholar

164. Rodgers, A. B, Bale, T. L. Germ cell origins of posttraumatic stress disorder risk: the transgenerational impact of parental stress experience. Biological Psychiatry 78(5), 2015, pp. 307-314.10.1016/j.biopsych.2015.03.018452633425895429Search in Google Scholar

165. Rodgers, A. B, Morgan, C. P., Leu, N. A., Bale, T. L. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress. Proceedings of the National Academy of Sciences of the United States of America 112(44), 2015, pp. 13699-13704.10.1073/pnas.1508347112464073326483456Search in Google Scholar

166. Rose, N. R., Klose, R. J. Understanding the relationship between DNA methylation and histone lysine methylation. Biochimica et Biophysica Acta 1839(12), 2014, pp. 1362-72.10.1016/j.bbagrm.2014.02.007431617424560929Search in Google Scholar

167. Roseboom, T., de Rooij, S. Painter, R. The Dutch famine and its long-term consequences for adult health. Early Human Development 82(8), 2006, pp. 485-491.10.1016/j.earlhumdev.2006.07.00116876341Search in Google Scholar

168. Rutter, M., Moffitt, T. E., Caspi, A. Gene-environment interplay and psychopathology: multiple varieties but real effects. Journal of Child Psychology and Psychiatry, and Allied Disciplines 47(3-4), 2006, pp. 226-61.10.1111/j.1469-7610.2005.01557.x16492258Search in Google Scholar

169. Ruzicka, W. B. Epigenetic mechanisms in the pathophysiology of psychotic disorders. Harvard Review of Psychiatry 23(3), 2015, pp. 212-222.10.1097/HRP.0000000000000048554757525943315Search in Google Scholar

170. Sapolsky, R. M. Mothering style and methylation. Nature Neuroscience 7(8), 2004, pp. 791-792.10.1038/nn0804-79115280887Search in Google Scholar

171. Scerri, T. S., Morris, A. P., Buckingham, L. L., Newbury, D. F., Miller, L. L., Monaco, A. P., Bishop, D.V ., Paracchini, S. DCDC2, KIAA0319 and CMIP are associated with reading-related traits. Biological Psychiatry 70(3), 2011, pp. 237-245.10.1016/j.biopsych.2011.02.005313983621457949Search in Google Scholar

172. Schubert, C. The genomic basis of the Williams-Beuren syndrome. Cellular and Molecular Life Sciences 66(7), 2009, pp. 1178-1197.10.1007/s00018-008-8401-y19039520Search in Google Scholar

173. Shen, E., Shulha, H., Weng, Z., Akbarian, S. Regulation of histone H3K4 methylation in brain development and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369 (1652), 2014.10.1098/rstb.2013.0514414203525135975Search in Google Scholar

174. Sherry, S. T., Ward, M. H., Kholodov, M., Baker, J., Phan, L., Smigielski, E. M., Sirotkin, K. dbSNP: the NCBI database of genetic variation. Nucleic Acid Research 29, 2001, pp. 308-311. 10.1093/nar/29.1.3082978311125122Search in Google Scholar

175. Simmons, J. P., Nelson, L. D., Simonsohn, U. False-positive psychology: undisclosed flexibility in data collection and analysis allows presenting anything as significant. Psychological Science 22(11), 2011, pp.1359-1366.10.1177/095679761141763222006061Search in Google Scholar

176. Simpson, J., Kelly, J. P. The impact of environmental enrichment in laboratory rats: Behavioural and neurochemical aspects. Behavioural Brain Research 222, 2011, pp. 246-264.10.1016/j.bbr.2011.04.00221504762Search in Google Scholar

177. Skinner, M. K. Endocrine disruptor induction of epigenetic transgenerational inheritance of disease. Molecular and Cellular Endocrinology 398(1-2), 2014, pp. 4-12.10.1016/j.mce.2014.07.019426258525088466Search in Google Scholar

178. Skinner, M. K. Environmental Epigenetics and a Unified Theory of the Molecular Aspects of Evolution: A Neo-Lamarckian concept that facilitates neo-Darwinian evolution. Genome Biology and Evolution 7(5), 2015, pp. 1296-302.10.1093/gbe/evv073445306825917417Search in Google Scholar

179. Skinner, M. K. Environmental stress and epigenetic transgenerational inheritance. BMC Medicine 12, 2014, p. 153.10.1186/s12916-014-0153-y424405925259699Search in Google Scholar

180. Skinner, M. K., Anway, M. D., Savenkova, M. I., Gore, A. C., Crews, D. Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior. PLoS One 3, 2008, p. e3745.10.1371/journal.pone.0003745258144019015723Search in Google Scholar

181. South, S. C., Krueger, R. F., Johnson, W., Iacono, W. G. Adolescent personality moderates genetic and environmental influences on relationships with parents. Journal of Personality and Social Psychology 94(5), 2008, pp. 899-912.10.1037/0022-3514.94.5.899260302718444746Search in Google Scholar

182. Spiteri, E., Konopka, G., Coppola, G., Bomar, J., Oldham, M., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B., Geschwind, D. H. Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. American Journal of Human Genetics 81(6), 2007, pp. 1144-1157.10.1086/522237227635017999357Search in Google Scholar

183. Suderman, M., Borghol, N., Pappas, J. J., Pinto Pereira, S. M., Pembrey, M., Hertzman, C., Power, C., Szyf, M. Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Medical Genomics 7, 2014, p. 13.10.1186/1755-8794-7-13400763124618023Search in Google Scholar

184. Szyf, M. DNA methylation, behavior and early life adversity. Journal of Genetics and Genomics 40(7), 2013, pp. 331-338.10.1016/j.jgg.2013.06.00423876773Search in Google Scholar

185. Szyf, M. Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning. Nature Neuroscience 17(1), 2014, pp. 2-4.10.1038/nn.360324369368Search in Google Scholar

186. Szyf, M. The early-life social environment and DNA methylation. Clinical Genetics 81(4), 2012, pp. 341-349.10.1111/j.1399-0004.2012.01843.x22236068Search in Google Scholar

187. Szyf, M., Bick, J. DNA methylation: a mechanism for embedding early life experiences in the genome. Child Development 84(1), 2013, pp. 49-57.10.1111/j.1467-8624.2012.01793.x403919922880724Search in Google Scholar

188. Szyf, M., Weaver, I., Meaney, M. Maternal care, the epigenome and phenotypic differences in behavior. Reproductive Toxicology 24(1), 2007, pp. 9-19.10.1016/j.reprotox.2007.05.00117561370Search in Google Scholar

189. Toth, M. Mechanisms of non-genetic inheritance and psychiatric disorders. Neuropsychopharmacology 40(1), 2015, pp. 129-140.10.1038/npp.2014.127426289024889369Search in Google Scholar

190. Trahan, L. H., Stuebing, K. K., Fletcher, J. M., Hiscock, M. The Flynn effect: a meta-analysis. Psychological Bulletin 140(5), 2014, pp. 1332-1360.10.1037/a0037173415242324979188Search in Google Scholar

191. Trerotola, M., Relli, V., Simeone, P., Alberti, S. Epigenetic inheritance and the missing heritability. Human Genomics 9, 2015, p. 17.10.1186/s40246-015-0041-3451741426216216Search in Google Scholar

192. Trzaskowski, M., Dale, P. S., Plomin, R. No genetic influence for childhood behavior problems from DNA analysis. Journal of the American Academy of Child and Adolescent Psychiatry 52, 2013, pp.1048-1056.10.1016/j.jaac.2013.07.016391476024074471Search in Google Scholar

193. Trzaskowski, M., Davis, O. S., DeFries, J. C., Yang, J., Visscher, P. M., Plomin, R. DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities. Behavior Genetics 43(4), 2013, pp. 267-73.10.1007/s10519-013-9594-x369018323609157Search in Google Scholar

194. Tuddenham, R. D. Soldier intelligence in world wars I and II. American Psychologist 3, 1948, pp. 54-56. 10.1037/h005496218911933Search in Google Scholar

195. Turkheimer, E. Spinach and ice cream: Why social science is so difficult. In. DiLalla, L. (ed.). Behavior genetics principles: Perspectives in development, personality, and psychopathology.Search in Google Scholar

American Psychological Association: Washington DC, 2004.Search in Google Scholar

196. Usher, C. L., McCarroll, S. A. Complex and multi-allelic copy number variation in human disease. Briefings in Functional Genomics 14(5), 2015, pp. 329-338.10.1093/bfgp/elv028457675726163405Search in Google Scholar

197. Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., Gocayne, J. D., Amanatides, P., Ballew, R. M., Huson, D. H., Wortman, J. R., Zhang, Q., Kodira, C. D., Zheng, X. H., Chen, L., Skupski, M., Subramanian, G., Thomas, P. D., Zhang, J., et al. The sequence of the human genome. Science 291(5507), 2001, pp. 1304-1351. Erratum in: Science 292(5523), 2001, p. 1838.Search in Google Scholar

198. Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcon, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., Monaco, A. P., Fisher, S. E. A functional genetic link between distinct developmental language disorders. The New England Journal of Medicine 359(22), 2008, pp. 2337-2345.10.1056/NEJMoa0802828275640918987363Search in Google Scholar

199. Waggoner, M. R., Tobias, U. Epigenetic determinism in science and society. New Genetics and Society 34:2, 2015, pp. 177-195.10.1080/14636778.2015.1033052451335226217167Search in Google Scholar

200. Weaver, I. C., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., Meaney, M. J. Epigenetic programming by maternal behavior. Nature Neuroscience 7(8), 2004, pp. 847-854.10.1038/nn127615220929Search in Google Scholar

201. Weber-Stadlbauer, U., Richetto, J., Labouesse, M. A., Bohacek, J., Mansuy, I. M., Meyer, U. Transgenerational transmission and modification of pathological traits induced by prenatal immune activation. Molecular Psychiatry Mar 29, 2016.10.1038/mp.2016.4127021823Search in Google Scholar

202. Weedon, M. N., Lango, H., Lindgren, C. M., Wallace, C., Evans, D. M., Mangino, M., Freathy, R. M., Perry, J. R., Stevens, S., Hall, A. S., Samani, N. J., Shields, B., Prokopenko, I., Farrall, M., Dominiczak, A., et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nature Genetics 40, 2008, pp. 575-583.10.1038/ng.121268122118391952Search in Google Scholar

203. Wei, Y., Schatten, H., Sun, Q. Y. Environmental epigenetic inheritance through gametes and implications for human reproduction. Human Reproduction Update 21(2), 2015, pp. 194-208.10.1093/humupd/dmu06125416302Search in Google Scholar

204. Weiss, I. C., Franklin, T. B., Vizi, S., Mansuy, I. M. Inheritable effect of unpredictable maternal separation on behavioral responses in mice. Frontiers in Behavioral Neuroscience 5, 2011, p. 3.10.3389/fnbeh.2011.00003303493721331159Search in Google Scholar

205. Welter, D., MacArthur, J., Morales, J., Burdett, T., Hall, P., Junkins, H., Klemm, A., Flicek, P., Manolio, T., Hindorff, L., Parkinson, H. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Research 42 (Database issue), 2014, pp. D1001-D1006.10.1093/nar/gkt1229396511924316577Search in Google Scholar

206. West-Eberhard, M. J. Are genes good markers of biological traits? In. Weinstein, M., Vaupel, J. W., Wachter, K. W. (eds.). Biosocial Surveys. The National Academies Press: Washington DC, 2008.Search in Google Scholar

207. Wolstenholme, J. T., Edwards, M., Shetty, S. R. J., Gatewood, J. D., Taylor, J. A., Rissman, E. F., et al. Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology 153, 2012, pp. 3828-3838.10.1210/en.2012-1195340434522707478Search in Google Scholar

208. Yahyavi, S. T., Zarghami, M., Marwah, U. A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability. Revista Brasileira de Psiquiatria: Orgão Oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina 36(1), 2014, pp. 89-94.10.1590/1516-4446-2012-099524402183Search in Google Scholar

209. Yan, W. Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance. Molecular and Cellular Endocrinology 398(1-2), 2014, pp. 24-30.10.1016/j.mce.2014.09.008426268125224488Search in Google Scholar

210. Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., Goddard, M. E., Visscher, P. M. Common SNPs explain a large proportion of the heritability for human height. Nature Genetics 42, 2010, pp. 565-569. 10.1038/ng.608323205220562875Search in Google Scholar

211. Yehuda, R., Daskalakis, N. P., Lehrner, A., Desarnaud, F., Bader, H. N., Makotkine, I., Flory, J. D., Bierer, L. M., Meaney, M. J. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. The American Journal of Psychiatry 171(8), 2014, pp. 872-880.10.1176/appi.ajp.2014.13121571412739024832930Search in Google Scholar

212. Zhang, F., Lupski, J. R. Non-coding genetic variants in human disease. Human Molecular Genetics 24 (R1), 2015, pp. R102-R110.10.1093/hmg/ddv259457200126152199Search in Google Scholar

213. Zheng, G., Dahl, J. A., Niu, Y., Fu, Y., Klungland, A., Yang, Y. G., He, C. Sprouts of RNA epigenetics. RNA Biology 10(6), 2013, pp. 915-918.10.4161/rna.24711390458923619745Search in Google Scholar

214. Zuk, O., Hechter, E., Sunyaev, S. R., Lander, E. S. The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America 109, 2012, pp. 1193-1198. 10.1073/pnas.1119675109326827922223662Search in Google Scholar