<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background:</bold> MiRNA-30c was a tumor suppressor in several human cancers, however, its association with clinicopathological features and prognosis in colorectal cancer (CRC) is unclear.<bold>Materials and Methods:</bold> The expression level of miRNA-30c in 192 pairs of colorectal cancer and adjacent normal tissues was detected by Quantitative RT-PCR, the association between miRNA-30c expression and clinical characteristics and prognosis were statistically analyzed.<bold>Results:</bold> miRNA-30c was significantly lower in CRC tissues specimens compared with matched normal adjacent tissue (P&lt;0.001). MiRNA-30c was positively correlated with tumor size (P=0.012), TMN stage (P=0.002) and lymph node metastasis (P=0.004). The univariate analysis showed CRC patients with low miRNA-30c had distinctly shorter overall survival (P&lt;0.001) than patients with high miRNA-30c expression level. The multivariate analysis was performed and informed that low miRNA-30c expression (P&lt;0.001) might be an independent prognostic predictor for poor prognosis.<bold>Conclusion:</bold> miRNA-30c could predict the prognosis of colorectal cancer which is helpful to choose reasonable treatment measures.</abstract>

Background: MiRNA-30c was a tumor suppressor in several human cancers, however, its association with clinicopathological features and prognosis in colorectal cancer (CRC) is unclear.Materials and Methods: The expression level of miRNA-30c in 192 pairs of colorectal cancer and adjacent normal tissues was detected by Quantitative RT-PCR, the association between miRNA-30c expression and clinical characteristics and prognosis were statistically analyzed.Results: miRNA-30c was significantly lower in CRC tissues specimens compared with matched normal adjacent tissue (P<0.001). MiRNA-30c was positively correlated with tumor size (P=0.012), TMN stage (P=0.002) and lymph node metastasis (P=0.004). The univariate analysis showed CRC patients with low miRNA-30c had distinctly shorter overall survival (P<0.001) than patients with high miRNA-30c expression level. The multivariate analysis was performed and informed that low miRNA-30c expression (P<0.001) might be an independent prognostic predictor for poor prognosis.Conclusion: miRNA-30c could predict the prognosis of colorectal cancer which is helpful to choose reasonable treatment measures.

Down-regulation of miRNA-30c predicts poor prognosis in Colorectal Cancer patients

The Affiliated Hospital of Hebei University, Baoding,

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: MiRNA-30c was a tumor suppressor in several human cancers, however, its association with clinicopathological features and prognosis in colorectal...

Down-regulation of miRNA-30c predicts poor prognosis in Colorectal Cancer patients

Published Online: Dec 30, 2016

Page range: 369 - 375

Received: Jun 07, 2016

Accepted: Oct 06, 2016

DOI: https://doi.org/10.1515/rrlm-2016-0037

Keywords
Colorectal cancer, miRNA-30c, Quantitative RT-PCR, Overall survival

© 2016 Liu Bin et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Down-regulation of miRNA-30c predicts poor prognosis in Colorectal Cancer patients

Published Online: Dec 30, 2016

Page range: 369 - 375

Received: Jun 07, 2016

Accepted: Oct 06, 2016

DOI: https://doi.org/10.1515/rrlm-2016-0037

KeywordsColorectal cancer, miRNA-30c, Quantitative RT-PCR, Overall survival

© 2016 Liu Bin et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Colorectal cancer, miRNA-30c, Quantitative RT-PCR, Overall survival