Uric Acid, Oxidative Stress and Inflammation in Chronic Heart Failure with Reduced Ejection Fraction

1. Anker SD, Doehner W, Rauchhaus M, Sharma R, Francis D, Knosalla C, et al. Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging. Circulation 2003;107(15):1991–7. DOI: 10.1161/01. CIR.0000065637.10517.A0Search in Google Scholar

2. Kittleson MM, St John ME, Bead V, Champion HC, Kasper EK, Russell SD, et al. Increased levels of uric acid predict haemodynamic compromise in patients with heart failure independently of B-type natriuretic peptide levels. Heart 2007;93(3):365–7. DOI: 10.1136/hrt.2006.09084510.1136/hrt.2006.090845186145017322514Search in Google Scholar

3. Cengel A, Turkoglu S, Turfan M, Boyaci B, et al. Serum uric acid levels as a predictor of in-hospital death in patients hospitalized for decompensated heart failure. Acta Cardiologica 2005;60(5):489–92. DOI: 10.2143/AC.60.5.200496910.2143/AC.60.5.200496916261779Search in Google Scholar

4. Sakai H, Tsutamoto T, Tsutsui T, Tanaka T, Ishikawa C, Horie M, et al. Serum level of uric acid, partly secreted from the failing heart, is a prognostic marker in patients with congestive heart failure. Circ J. 2006;70(8):1006–11. DOI: 10.1253/circj.70.100610.1253/circj.70.100616864933Search in Google Scholar

5. Tamariz L, Harzand A, Palacio A, Verma S, Jones J, Hare J, et al. Uric acid as a predictor of all-cause mortality in heart failure: a meta-analysis. Congest Heart Fail. 2011;17(1):25–30. DOI: 10.1111/j.1751-7133.2011.00200.x10.1111/j.1751-7133.2011.00200.x21272224Search in Google Scholar

6. Gotsman I, Keren A, Lotan C, Zwas DR. Changes in uric acid levels and allopurinol use in chronic heart failure: association with improved survival. J Card Fail. 2012;18(9):694-701. DOI: 10.1016/j.cardfail.2012.06.52810.1016/j.cardfail.2012.06.52822939038Search in Google Scholar

7. Ashraf M, Samra ZQ. Subcellular distribution of xanthineoxidase during cardiac ischemia and reperfusion: an immunocytochemical study. J Submicrosc Cytol Pathol 1993; 25(2):193–201.Search in Google Scholar

8. Terada LS, Guidot DM, Leff JA, Willingham IR, Hanley ME, Piermattei D, et al. Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity. Proc Natl Acad Sci USA. 1992;89(8):3362–6. DOI: 10.1073/pnas.89.8.336210.1073/pnas.89.8.3362488671314387Search in Google Scholar

9. Lazzarino G, Raatikainen P, Nuutinen M, Nissinen J, Tavazzi B, Di Pierro D, et al. Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery. Circulation. 1994;90(1):291–7. DOI: 10.1161/01.CIR.90.1.29110.1161/01.CIR.90.1.2918026011Search in Google Scholar

10. Leyva F, Anker SD, Godsland IF, Teixeira M, Hellewell PG, Kox WJ, et al. Uric acid in chronic heart failure: a marker of chronic inflammation. Eur Heart J 1998;19(12):1814–22. DOI: 10.1053/euhj.1998.118810.1053/euhj.1998.11889886724Search in Google Scholar

11. Anker SD, Leyva F, Poole-Wilson PA, Kox WJ, Stevenson JC, Coats AJ. Relation between serum uric acid and lower limb blood flow in patients with chronic heart failure. Heart. 1997;78(1):39–43. DOI: 10.1136/hrt.78.1.3910.1136/hrt.78.1.394848629290400Search in Google Scholar

12. Doehner W, Rauchhaus M, Florea VG, Sharma R, Bolger AP, Davos CH, et al. Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance. Am Heart J. 2001;141(5):792–9. DOI: 10.1067/mhj.2001.11436710.1067/mhj.2001.11436711320368Search in Google Scholar

13. Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. Eur J Heart Fail 2008;10(10):933–989. DOI: 10.1016/j.ejheart.2008.08.00510.1016/j.ejheart.2008.08.00518826876Search in Google Scholar

14. Buchmann R, Hasilik A, Van Dyke TE, Lange DE. Amplified Crevicular Leukocyte Activity in Aggressive Periodontal Disease. J Dent Res. 2002. 81(10):716-721. DOI: 10.1177/15440591020810101210.1177/15440591020810101212351672Search in Google Scholar

15. Cabana VG, Reardon CA, Feng N, Neath S, Lukens J, Getz GS. Serum paraoxonase: effect of the apolipoprotein composition of HDL and the acute phase response. J Lipid Res. 2003; 44(4):780-792. DOI: 10.1194/jlr. M200432-JLR20010.1194/jlrSearch in Google Scholar

16. Krishnan E. Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010. J Am Heart Assoc. 2014;3(2):e000157. DOI: 10.1161/JAHA.113.00015710.1161/JAHA.113.000157418751424627417Search in Google Scholar

17. Sinan Deveci O, Kabakci G, Okutucu S, Tulumen E, Aksoy H, Baris Kaya E, et al. The association between serum uric acid level and coronary artery disease. Int J Clin Pract. 2010; 64(7):900-7. DOI: 10.1111/j.1742-1241.2009.02263.x10.1111/j.1742-1241.2009.02263.x20584223Search in Google Scholar

18. Duran M, Kalay N, Akpek M, Orscelik O, Elcik D, Ocak A, et al. High levels of serum uric acid predict severity of coronary artery disease in patients with acute coronary syndrome. Angiology. 2012;63(6):448-52. DOI: 10.1177/000331971142686810.1177/000331971142686822096206Search in Google Scholar

19. Gotsman I, Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA. Uric acid and oxidative stress. Curr Pharm Des. 2005;11(32):4145-51. DOI: 10.2174/13816120577491325510.2174/13816120577491325516375736Search in Google Scholar

20. Huang H, Huang B, Li Y, Huang Y, Li J, Yao H, et al. Uric acid and risk of heart failure: a systematic review and meta-analysis. Eur J Heart Fail. 2014;16(1):15-24. DOI: 10.1093/eurjhf/hft13210.1093/eurjhf/hft13223933579Search in Google Scholar

21. Filippatos GS, Ahmed MI, Gladden JD, Mujib M, Aban IB, Love TE, et al. Hyperuricaemia, chronic kidney disease, and outcomes in heart failure: potential mechanistic insights from epidemiological data. Eur Heart J. 2011;32(6):712-20. DOI: 10.1093/eurheartj/ehq47310.1093/eurheartj/ehq473305620521199831Search in Google Scholar

22. Amin A, Vakilian F, Maleki M. Serum uric acid levels correlate with filling pressures in systolic heart failure. Congest Heart Fail. 2011;17(2):80-4. DOI: 10.1111/j.1751-7133.2010.00205.x10.1111/j.1751-7133.2010.00205.x21449996Search in Google Scholar

23. Zhang YH, Lü R, Zhao XY, Kang LM, Yang YJ, Zhang J. Association of serum uric acid, plasma NT-proBNP, Hs-C reactive protein and invasive hemodynamic parameters in patients with heart failure. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37(2):126-9.Search in Google Scholar

24. Wojciechowska C, Romuk E, Tomasik A, Skrzep-Poloczek B, Nowalany-Kozielska E, Birkner E, Jache W. Oxidative stress markers and c-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy. Mediators Inflamm. 2014;2014:147040. DOI: 10.1155/2014/14704010.1155/2014/147040Search in Google Scholar

25. Cicoira M, Zanolla L, Rossi A, Golia G, Franceschini L, Brighetti G, et al. Elevated serum uric acid levels are associated with diastolic dysfunction in patients with dilated cardiomyopathy. Am Heart J. 2002; 143(6):1107-11. DOI: 10.1067/mhj.2002.12212210.1067/mhj.2002.122122Search in Google Scholar

26. Vaduganathan M, Greene SJ, Ambrosy AP, Mentz RJ, Subacius HP, Chioncel O, et al. Relation of serum uric acid levels and outcomes among patients hospitalized for worsening heart failure with reduced ejection fraction (from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan trial). Am J Cardiol. 2014;114(11):1713-21. DOI: 10.1016/j.amjcard.2014.09.00810.1016/j.amjcard.2014.09.008Search in Google Scholar

27. Pinelli M, Bindi M, Filardo FP, Moroni F, Castiglioni M. Serum uric acid levels correlate with left ventricular ejection fraction and systolic pulmonary artery pressure in patients with heart failure. [Article in Italian] Recenti Prog Med. 2007;98(12):619-23.Search in Google Scholar

28. Borghi C, Cosentino ER, Rinaldi ER, Cicero AF. Uricaemia and ejection fraction in elderly heart failure outpatients. Eur J Clin Invest. 2014;44(6):573-8. DOI: 10.1111/eci.1227310.1111/eci.12273Search in Google Scholar

29. Hare JM, Mangal B, Brown J, Fisher C Jr, Freudenberger R, Colucci WS, et al. Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study. J Am Coll Cardiol. 2008; 51(24):2301-9. DOI: 10.1016/j.jacc.2008.01.06810.1016/j.jacc.2008.01.068Search in Google Scholar

30. Huang H, Huang B, Li Y, Huang Y, Li J, Yao H, et al. Uric acid and risk of heart failure: a systematic review and meta-analysis. Eur J Heart Fail. 2014;16(1):15-24. DOI: 10.1093/eurjhf/hft13210.1093/eurjhf/hft132Search in Google Scholar

31. Keith M, Geranmayegan A, Sole MJ, Kurian R, Robinson A, Omran AS, et al. Increased oxidative stress in patients with congestive heart failure. J Am Coll Cardiol. 1998;31(6):1352–6. DOI: 10.1016/S0735-1097(98)00101-610.1016/S0735-1097(98)00101-6Search in Google Scholar

32. Díaz-Vélez CR, García-Casti-eiras S, Mendoza-Ramos E, Hernández-López E. Increased malondialdehyde in peripheral blood of patients with congestive heart failure. Am Heart J. 1996;131(1):146-52. DOI: 10.1016/S0002-8703(96)90063-010.1016/S0002-8703(96)90063-0Search in Google Scholar

33. Reina-Couto M, Carvalho J, Valente MJ, Vale L, Afonso J, Carvalho F, et al. Impaired resolution of inflammation in human chronic heart failure. Eur J Clin Invest. 2014; 44(6):527-38. DOI: 10.1111/eci.1226510.1111/eci.1226524673112Search in Google Scholar

34. Wilson Tang WH, Wu Y, Mann S, Pepoy M, Shrestha K, Borowski AG, et al. Diminished Anti-Oxidant Activity of High-Density Lipoprotein-Associated Proteins in Systolic Heart Failure. Circ Heart Fail. 2011;4(1):59–64. DOI: 10.1161/CIRCHEARTFAILURE.110.95834810.1161/CIRCHEARTFAILURE.110.958348302383821062973Search in Google Scholar

35. Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, et al. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation. 2002;106(24):3073–8. DOI: 10.1161/01.CIR.0000041431.57222.AF10.1161/01.CIR.0000041431.57222.AFSearch in Google Scholar