<abstract xmlns="http://www.w3.org/1999/xhtml"><p>T cells (especially T helper cells) seem to be strongly associated with systemic sclerosis pathogenesis. Th17-IL-17 axis was proved to be involved in the pathogenesis of multiple autoimmune diseases. By performing a comprehensive research of the literature indexed in PubMed database, the current review summarizes current knowledge related to Th17 and IL-17 in systemic sclerosis. While there is promising data suggesting inhibition of Tregulatory and Th1 signals on one hand and promotion of Th17 and Th2 signals on the other, studies that include prospective and integrated analysis of Tregulatory, Th17, Th1, Th2 (cells and derived cytokines) on the same cohort of Ssc patients are warranted.</p></abstract>

T cells (especially T helper cells) seem to be strongly associated with systemic sclerosis pathogenesis. Th17-IL-17 axis was proved to be involved in the pathogenesis of multiple autoimmune diseases. By performing a comprehensive research of the literature indexed in PubMed database, the current review summarizes current knowledge related to Th17 and IL-17 in systemic sclerosis. While there is promising data suggesting inhibition of Tregulatory and Th1 signals on one hand and promotion of Th17 and Th2 signals on the other, studies that include prospective and integrated analysis of Tregulatory, Th17, Th1, Th2 (cells and derived cytokines) on the same cohort of Ssc patients are warranted.

IL-17 and Th17 cells in systemic sclerosis: a comprehensive review

“Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"IL-17 and Th17 cells in systemic sclerosis: a comprehensive review"}

T cells (especially T helper cells) seem to be strongly associated with systemic sclerosis pathogenesis. Th17-IL-17 axis was proved to be involved in the...

IL-17 and Th17 cells in systemic sclerosis: a comprehensive review

Published Online: Nov 15, 2017

Page range: 198 - 204

Received: Jun 20, 2017

DOI: https://doi.org/10.1515/rjim-2017-0027

Keywords
Systemic sclerosis, IL-17A, Th17, IL-17F

© 2017 Paul Bălănescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

IL-17 and Th17 cells in systemic sclerosis: a comprehensive review

Published Online: Nov 15, 2017

Page range: 198 - 204

Received: Jun 20, 2017

DOI: https://doi.org/10.1515/rjim-2017-0027

KeywordsSystemic sclerosis, IL-17A, Th17, IL-17F

© 2017 Paul Bălănescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Systemic sclerosis, IL-17A, Th17, IL-17F