<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction</bold>. Little is known about the relationship between insulin resistance and proliferative diabetic retinopathy in type 1 diabetes. The aim of this article is to explore the relationship between sight-threatening proliferative diabetic retinopathy and insulin resistance.<bold>Methods</bold>. This was a cross-sectional study that included 167 type 1 diabetes patients. Insulin resistance was assessed using eGDR (estimated glucose disposal rate) formula. Diabetic retinopathy was assessed by ophthalmoscopy using Early Treatment Diabetic Retinopathy classification. The association between eGDR and proliferative diabetic retinopathy was assessed in uni- and multivariate models using stepwise logistic regression of covariates. The contribution of individual predictors in the final regresion model was examined using Wald statistic.<bold>Results</bold>. Significantly lower eGDR’s values were observed in patients with proliferative diabetic retinopathy: 5.5 <italic>vs</italic>. 7 (p = 0.002). The results remained significant (p &lt; 0.001) after adjusting for multiple covariates (sex, diabetes duration, body mass index, HDL cholesterol, LDL cholesterol, triglycerides, smoking). eGDR variable was retained in the final model of stepwise logistic regression (p &lt; 0.001) and showed the strongest association with proliferative diabetic retinopathy (Wald = 12.73).<bold>Conclusions</bold>. In type 1 diabetes patients insulin resistance was the most important independent risk factor associated with diabetic proliferative retinopathy.</abstract>

Introduction. Little is known about the relationship between insulin resistance and proliferative diabetic retinopathy in type 1 diabetes. The aim of this article is to explore the relationship between sight-threatening proliferative diabetic retinopathy and insulin resistance.Methods. This was a cross-sectional study that included 167 type 1 diabetes patients. Insulin resistance was assessed using eGDR (estimated glucose disposal rate) formula. Diabetic retinopathy was assessed by ophthalmoscopy using Early Treatment Diabetic Retinopathy classification. The association between eGDR and proliferative diabetic retinopathy was assessed in uni- and multivariate models using stepwise logistic regression of covariates. The contribution of individual predictors in the final regresion model was examined using Wald statistic.Results. Significantly lower eGDR’s values were observed in patients with proliferative diabetic retinopathy: 5.5 vs. 7 (p = 0.002). The results remained significant (p < 0.001) after adjusting for multiple covariates (sex, diabetes duration, body mass index, HDL cholesterol, LDL cholesterol, triglycerides, smoking). eGDR variable was retained in the final model of stepwise logistic regression (p < 0.001) and showed the strongest association with proliferative diabetic retinopathy (Wald = 12.73).Conclusions. In type 1 diabetes patients insulin resistance was the most important independent risk factor associated with diabetic proliferative retinopathy.

The association between insulin resistance and proliferative retinopathy in type 1 diabetes

“Prof. N. C. Paulescu” National Instititute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania

“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

“Elias” Emergency Hospital, Bucharest, Romania

Romanian Journal of Internal Medicine

This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License.

Introduction. Little is known about the relationship between insulin resistance and proliferative diabetic retinopathy in type 1 diabetes. The aim of this...

The association between insulin resistance and proliferative retinopathy in type 1 diabetes

Published Online: Oct 14, 2015

Page range: 261 - 266

Received: May 30, 2015

DOI: https://doi.org/10.1515/rjim-2015-0034

Keywords
type 1 diabetes, insulin resistance, estimated glucose disposal rate, proliferative diabetic retinopathy

© 2015 Irina Duţă et al., published by De Gruyter Open

This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License.

The association between insulin resistance and proliferative retinopathy in type 1 diabetes

Published Online: Oct 14, 2015

Page range: 261 - 266

Received: May 30, 2015

DOI: https://doi.org/10.1515/rjim-2015-0034

Keywordstype 1 diabetes, insulin resistance, estimated glucose disposal rate, proliferative diabetic retinopathy

© 2015 Irina Duţă et al., published by De Gruyter Open

This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License.

Keywords
type 1 diabetes, insulin resistance, estimated glucose disposal rate, proliferative diabetic retinopathy