<abstract xmlns="http://www.w3.org/1999/xhtml"> Background. Genetic polymorphism of renin-angiotensin-aldosterone system affects the pathogenesis of hypertension (HTN), ischemic heart disease (IHD) and heart failure (HF). The purpose of our study is to analyze A/G renin genetic polymorphism in heart failure patients. Methods. We investigated renin polymorphism in 83 subjects hospitalized in the Cardiology Department of the Rehabilitation Hospital Cluj-Napoca, using the PCR amplification method. 43 patients were diagnosed with heart failure [NYHA III-IV class], and 40 subjects without cardiovascular disease (control group). The NT-proBNP and the presence of cardiovascular risk factors were assessed. Results. Heart failure etiology was IHD in 60.46 % of patients. The average value of NT-pro BNP was 2991.24 ± 2034.6 pg/ml. As it was expected, HF patients presented low lipid levels: total cholesterol = 162.36 ± 38.28mg/dl, LDL-Cholesterol = 104.88 ± 27.60mg/dl, triglycerides= 109.12 ± 55.84mg/dl, HDL-Co= 35.68 ± 9.55mg/dl. A/G renin genetic polymorphism [with pathogenic potential] in heart failure patients was of 60.46% (homozygote 4.65% and heterozygote 55.81%). Conversely, pathogenic mutations were found only in 38.46% of hypertensive patients, but also in 55.88% and 22.22% patients with obesity/overweight and diabetes. The heterozygote form was found in only 37.5% of control subjects. Conclusion. This study showed no involvement of A/G renin polymorphisms in the pathogenesis of HF.</abstract>

Background. Genetic polymorphism of renin-angiotensin-aldosterone system affects the pathogenesis of hypertension (HTN), ischemic heart disease (IHD) and heart failure (HF). The purpose of our study is to analyze A/G renin genetic polymorphism in heart failure patients.  Methods. We investigated renin polymorphism in 83 subjects hospitalized in the Cardiology Department of the Rehabilitation Hospital Cluj-Napoca, using the PCR amplification method. 43 patients were diagnosed with heart failure [NYHA III-IV class], and 40 subjects without cardiovascular disease (control group). The NT-proBNP and the presence of cardiovascular risk factors were assessed. Results. Heart failure etiology was IHD in 60.46 % of patients. The average value of NT-pro BNP was 2991.24 ± 2034.6 pg/ml. As it was expected, HF patients presented low lipid levels: total cholesterol = 162.36 ± 38.28mg/dl, LDL-Cholesterol = 104.88 ± 27.60mg/dl, triglycerides= 109.12 ± 55.84mg/dl, HDL-Co= 35.68 ± 9.55mg/dl. A/G renin genetic polymorphism [with pathogenic potential] in heart failure patients was of 60.46% (homozygote 4.65% and heterozygote 55.81%). Conversely, pathogenic mutations were found only in 38.46% of hypertensive patients, but also in 55.88% and 22.22% patients with obesity/overweight and diabetes. The heterozygote form was found in only 37.5% of control subjects. Conclusion. This study showed no involvement of A/G renin polymorphisms in the pathogenesis of HF.

Renin Genetic Polymorphism in Heart Failure Patients

“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

Rehabilitation Hospital, Cardiology Department, Cluj-Napoca, Romania

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Renin Genetic Polymorphism in Heart Failure Patients"}

Background. Genetic polymorphism of renin-angiotensin-aldosterone system affects the pathogenesis of hypertension (HTN), ischemic heart disease (IHD) and heart...

Renin Genetic Polymorphism in Heart Failure Patients

Published Online: Oct 07, 2015

Page range: 39 - 45

Received: Feb 10, 2015

DOI: https://doi.org/10.1515/rjim-2015-0005

Keywords
renin genetic polymorphism, heart failure

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Renin Genetic Polymorphism in Heart Failure Patients

Published Online: Oct 07, 2015

Page range: 39 - 45

Received: Feb 10, 2015

DOI: https://doi.org/10.1515/rjim-2015-0005

Keywordsrenin genetic polymorphism, heart failure

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
renin genetic polymorphism, heart failure