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Survival and stability of patients with urothelial cancer and spinal bone metastases after palliative radiotherapy

Robert Foerster

Robert Foerster

  • Department of Radiation Oncology, University Hospital HeidelbergHeidelberg, Germany
  • National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)Heidelberg, Germany
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Foerster, Robert
, 
Katharina Hees

Katharina Hees

Department of Medical Biometry, University Hospital HeidelbergHeidelberg, Germany
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Hees, Katharina
, 
Thomas Bruckner

Thomas Bruckner

Department of Medical Biometry, University Hospital HeidelbergHeidelberg, Germany
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Bruckner, Thomas
, 
Tilman Bostel

Tilman Bostel

  • Department of Radiation Oncology, University Hospital HeidelbergHeidelberg, Germany
  • National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)Heidelberg, Germany
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Bostel, Tilman
, 
Ingmar Schlampp

Ingmar Schlampp

  • Department of Radiation Oncology, University Hospital HeidelbergHeidelberg, Germany
  • National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)Heidelberg, Germany
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Schlampp, Ingmar
, 
Tanja Sprave

Tanja Sprave

  • Department of Radiation Oncology, University Hospital HeidelbergHeidelberg, Germany
  • National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)Heidelberg, Germany
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Sprave, Tanja
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Nils H. Nicolay

Nils H. Nicolay

  • Department of Radiation Oncology, University Hospital HeidelbergHeidelberg, Germany
  • National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)Heidelberg, Germany
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Nicolay, Nils H.
, 
Juergen Debus

Juergen Debus

  • Department of Radiation Oncology, University Hospital HeidelbergHeidelberg, Germany
  • National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)Heidelberg, Germany
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Debus, Juergen
 and 
Harald Rief

Harald Rief

  • Department of Radiation Oncology, University Hospital HeidelbergHeidelberg, Germany
  • National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)Heidelberg, Germany
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Rief, Harald
  
Sep 14, 2017
Survival and stability of patients with urothelial cancer and spinal bone metastases after palliative radiotherapy's Cover Image
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Article Category: Research Article
Published Online: Sep 14, 2017
Page range: 189 - 194
Received: Jun 09, 2017
Accepted: Aug 14, 2017
DOI: https://doi.org/10.1515/raon-2017-0038
Keywords
© 2017 Robert Foerster, Katharina Hees, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Tanja Sprave, Nils H. Nicolay, Juergen Debus, Harald Rief, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Taneichi et al. score for spinal bone metastases of the (A) thoracic and (B) lumbar spine.
Taneichi et al. score for spinal bone metastases of the (A) thoracic and (B) lumbar spine.

Figure 2

Bone mineral density measurement in Hounsfield units by manual region of interest setting (A) before radiotherapy and (B) after radiotherapy within the spinal bone metastases.
Bone mineral density measurement in Hounsfield units by manual region of interest setting (A) before radiotherapy and (B) after radiotherapy within the spinal bone metastases.

Figure 3

Overall survival - survival of all patients with urothelial cancer and spinal bone metastases from first diagnosis of urothelial cancer until death.
Overall survival - survival of all patients with urothelial cancer and spinal bone metastases from first diagnosis of urothelial cancer until death.

Figure 4

Bone survival - survival of all patients with urothelial cancer and spinal bone metastases from first diagnosis of spinal bone metastases until death.
Bone survival - survival of all patients with urothelial cancer and spinal bone metastases from first diagnosis of spinal bone metastases until death.

Figure 5

Radiotherapy survival - survival of all patients with urothelial cancer and spinal bone metastases from start of palliative radiotherapy until death.
Radiotherapy survival - survival of all patients with urothelial cancer and spinal bone metastases from start of palliative radiotherapy until death.

Patients’ characteristics of all patients with urothelial cancer and spinal bone metastases

Patients’ characteristics
Age
 Median 70 years
 Range 35-82 years
n %
Gender
 Female 8 21.0%
 Male 30 79.0%
Karnofsky performance status
 40-60% 12 31.6%
 70% 17 44.7%
 80% 9 23.7%
Histology
 Urothelial carcinoma 38 100%
Localization of metastases
 Thoracic 18 47.4%
 Lumbar 20 52.6%
Number of metastases
 Single 15 39.5%
 Multiple 23 60.5%
Distant extra-osseous metastases
 Overall 9 23.7%
 Lungs 6 15.8%
 Liver 5 13.2%
 Brain 2 5.3%
Surgical corset
 Yes 6 15.8%
 No 32 84.2%
Treatment indications
 Instability 7 18.4%
 Neurological symptoms 1 2.6%
 Pain 30 79.0%
Radiotherapy schedule
 10 x 3 Gy 24 63.2%
 14 x 2.5 Gy 3 7.9%
 20 x 2 Gy 11 28.9%
Systemic therapy
 Chemotherapy 14 36.8%
 Bisphosphonates 4 10.5%
Language:
English
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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