Helical tomotherapy is an intensity-modulated radiotherapy (IMRT) dedicated system with an integrated megavoltage computed tomography (MVCT) scanner for patient position verification. The helical IMRT is able to produce highly conformal dose distribution to large and complex target volumes such as in nasopharyngeal carcinoma and other head and neck cancers. Helical tomotherapy can lower the mean dose to the salivary glands, with improved dose homogeneity and conformity compared to other IMRT techniques.1-5 In our centre, step and shoot IMRT was the standard radiotherapy technique in most nasopharyngeal carcinoma patients with curative intent treated since 2000. The helical tomotherapy unit, Hi-ART II (TomoTherapy Inc., Madison, WI) has been installed in March 2012. The aim of this study was to assess the treatment outcome in terms of loco-regional failure free survival (LRFFS), distant metastasis free survival (DMFS), overall survival (OS), and treatment toxicities of the first 100 non-metastatic nasopharyngeal carcinoma patients treated by this technique. Dosimetric details were also reported.
We reviewed the first 100 patients with newly-diagnosed non-metastatic nasopharyngeal carcinoma patients treated with curative intent by helical tomotherapy between April 2012 and December 2015. Pretreatment evaluations consisted of physical examination, pre-treatment dental evaluations, and laboratory studies. Good bone marrow, renal, and liver function tests were required. Contrast enhanced computer tomography (CT) scan or magnetic resonance imaging (MRI) of the nasopharynx and the neck region, chest x-ray, and bone scan were performed. The diseases were staged according to the American Joint Committee on Cancer Staging 2010, 7th edition.6
Target delineation was done according to RTOG 0225.7 The gross target volume (GTV) included the primary tumour and nodes larger than 1 cm in diameter or nodes with necrotic centres. Clinical target volume 70 (CTV 70) was equivalent to the GTV plus 5 mm margin. CTV 59.4 was defined as CTV 70 plus entire nasopharynx with retropharyngeal lymph nodes, pterygoid fossa, parapharyngeal space, inferior sphenoid sinus, posterior third of the nasal cavity and maxillary sinuses, skull base, and high risk nodal groups (upper deep jugular, subdigastric, midjugular, posterior cervical, and retropharyngeal lymph nodes). CTV 54 included the lower jugular and supraclavicular lymph nodes. Planning target volume (PTV) was created by adding a circumferential margin of 5 mm to each CTV. We also contoured the critical organs at risk such as bilateral parotid glands, brainstem, spinal cord, optic nerves and chiasm. For planning, the helical tomotherapy Planning Station (Hi-Art Version 4.2.3.9 TomoTherapy Inc., Madison, WI) was used with a Field Width (FW) of 5.02 cm, a Pitch Factor (PF) of 0.287, and a Modulation Factor (MF) of 3.0. ICRU83 recommendations were implemented for the optimization procedure. The dose prescriptions in our simultaneous integrated boost technique (SIB) were 70 Gy for PTV 70 at 2.12 Gy/fraction, 59.4 Gy for PTV 59.4 at 1.8 Gy/fraction, and 54 Gy for PTV 54 at 1.64 Gy/fraction. Treatment was delivered in five fractions per week for a total of 33 fractions.
Acute adverse events of concurrent chemoradiotherapy were evaluated at weekly visits using version 3.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE).8 Patients were evaluated for disease control, survival, and late toxicities of radiotherapy at 2–3 month intervals for the first 2 years, at 3–6 month intervals between the third and fifth year. Late toxicities were assessed by the RTOG/EORTC late radiation morbidity scoring system.9 At every visit fiber-optic endoscopy by an otolaryngologists has been done. CT scan of the neck was performed every 6 months in the first 2 years and annually thereafter.
OS and LRFFS were estimated using the Kaplan-Meier method. OS was defined as the time from beginning of treatment to the date of death of any cause. LRFFS was defined as the time between beginning of treatment and local or regional recurrence/progression, or death due to nasopharyngeal cancer or due to unknown causes with undocumented site of failure. DMFS was defined from beginning of treatment to the date of diagnosis of distant metastases.
The results presented herein resulted from a retrospective study based on the analysis of medical records. This study was approved by the Ethics committee of Faculty of Medicine, Chiang Mai University.
A hundred non-metastatic nasopharyngeal carcinoma patients have been treated with curative intent by helical tomotherapy. Baseline characteristics are shown in Table 1. The median age was 51 years (interquartile ranges [IQR]: 42.5–57.0). Most patients (66%) had undifferentiated non-keratinizing nasopharyngeal carcinoma.
Patient and treatment characteristics
Characteristics | Values |
---|---|
Gender | |
Female | 38 (38%) |
Male | 62 (62%) |
Histological subtype | |
Keratinizing | 2 (2%) |
Non-keratinizing; differentiated | 32 (32%) |
Non-keratinizing; undifferentiated | 66 (66%) |
Stage | |
II | 23 (23%) |
III | 45 (45%) |
IVA | 21 (21%) |
IVB | 11 (11%) |
T stage | |
T1 | 28 (28%) |
T2 | 30 (30%) |
T3 | 20 (20%) |
T4 | 22 (22%) |
N stage | |
N0 | 5 (5%) |
N1 | 30 (30%) |
N2 | 54 (54%) |
N3a | 7 (7%) |
N3b | 4 (4%) |
Dose statistic | |
D95% of PTV70, mean (SD) | 70.2 (0.5) |
D95% of PTV59.4, mean (SD) | 59.8 (0.6) |
D95% of PTV54, mean (SD) | 54.3 (0.8) |
Conformity index (CI), mean (SD) | 0.89 (0.13) |
Homogeneity index (HI), mean (SD) | 0.06 (0.07) |
D2% of spinal cord, median (SD) | 34.1 (4.4) |
D2 cc of brainstem, mean (SD) | 53.3 (6.3) |
D50 of ipsilateral parotid gland, mean (SD) | 38.5 (11.2) |
D50 of contralateral parotid gland, mean (SD) | 28.4 (6.7) |
Treatment protocols for nasopharyngeal carcinoma in our centre include concurrent chemoradiotherapy plus either 3 cycles of induction chemotherapy (IC) or 3 cycles of adjuvant chemotherapy (AC). Of the 100 patients, all of them received platinum-based concurrent chemoradiotherapy, either weekly cisplatin 40 mg/m2 × 6 cycles (53%), cisplatin 70 mg/m2 every 21 days × 3 cycles (11%), or weekly carboplatin 100 mg/m2 × 6 cycles (36%). Forty-one patients (41%) received 3 cycles of IC, because of N2 and N3a disease in 29% and because of a waiting time for radiotherapy of more than 6 weeks in 15% of patients. Thirty patients (30%) received IC with PF regimen (cisplatin 100 mg/ m2 on day 1 or carboplatin with area under curve (AUC) 5 on day 1 plus 5-FU 1000 mg/m2/d in day 1–4 every 21 days). Eleven patients (11%) received IC with TPF regimen (cisplatin 75 mg/m2 on day 1, docetaxel 75 mg/m2 on day 1, 5-FU 750 mg/m2/d in day 1–4 every 21 days). We performed CT scan after 3 cycles of IC for response evaluation and planning radiotherapy. Fifty-nine patients (59%) received AC with PF regimen (cisplatin 100 mg/ m2 on day 1 plus 5-FU 1000 mg/m2/d in day 1–4 every 21 days in 23 patients and carboplatin with area under curve (AUC) 5 on day 1 plus 5-FU 1000 mg/m2/d in day 1–4 every 21 days in 36 patients).
With a median follow up time of 33 months (inter-quartile range, IQR: 25–41 months), the 2-year LRFFS, DMFS and OS rates were 94%, 96%, and 99% respectively (Figures 1–3). Ninety-nine patients were alive at the last follow up of whom 84 patients without any evidence of disease. No patients developed second primary cancer.
Acute and late toxicities of our study are shown in the bottom of Table 2. Acute grade 3 Pharyngoesophagitis and mucositis occurred in 51% and 37% respectively, responsible for a weight loss of more than 15% from baseline in 42 patients (42%) and with a nasogastric (NG) tube insertion in 10 patients (10%, in all during concurrent chemoradiotherapy). Five patients (5%) had grade 3 acute radiation dermatitis. No patient died during concurrent chemoradiotherapy. Late pharyngoesophagitis was of grade 1 and was registered in only 2% of the patients. We also found grade 1, 2 and 3 late xerostomia in 17%, 78% and 5% of the patients, respectively.
Comparative studies of outcome and toxicities in NPC treated by HT concurrent with chemotherapy
Study | Median Follow up (Range) (month) | No. of CCRT (%) | LRFFS (%) | DMFS (%) | OS (%) | Severe toxicity (grade > 2) | ||||
---|---|---|---|---|---|---|---|---|---|---|
Acute Dermatitis (%) | Acute Mucositis (%) | Acute Pharyngitis (%) | Acute Xerostomia (%) | Late Xerostomia (%) | ||||||
Wong |
34 (9-50) | 70 | 93.6 (3 yr) | 86.6 (3 yr) | 87.2 (3 yr) | - | 67.4 | - | - | 2.3 |
Wolden |
35 (3-74) | 93 | 91 (3 yr) | 78 (3 yr) | - | - | - | - | - | - |
Kam |
29 (8-45) | 30 | 92 (3 yr) | 79 (3 yr) | 90 (3 yr) | - | 92 | - | 75 | 23 (2 yr) |
Lee |
31 (6-55) | 65 | 89.3 (2 yr) | 84.7 (2 yr) | 80.2 (2 yr) | - | 4.4 (grade4) | - | - | 3.1 |
Tham |
36.5 | 100 | 93.1 (3 yr) | - | - | - | 29 | - | 3 | - |
Lee |
31 (7-22) | 75 | 98 (4 yr) | 66 (4 yr) | 88 (4 yr) | - | 94 | - | - | 2.5 ( 2 yr) |
Liu |
13 (8/18) | 58 | 100 (13 M) | - | - | 5 | 79 | - | 5 | - |
Wang |
47.1 (11-68) | 83 | 94 (4 yr) | 85 (4 yr) | 86.1 (4 yr) | - | 33.3 | - | 4.7 | 12.3 (2 yr) |
Sultanem |
21.8 (5-49) | 91 | 100 (4 yr) | 57 (4 yr) | 94 (4 yr) | - | 51 (grade3) | - | - | - |
Du |
32 (3-38) | 64 | 96.1 (3 yr) | 92 (3 yr) | 86.3 (3 yr) | 4.7 | 3.2 | - | 0 | - |
Leung |
41 (0.2-67) | 62.5 | 97 (5 yr) | 84.6 (5 yr) | - | 0 | 4 | - | - | 0 |
Du |
23.7 (12-38) | 100 | 92.2 (2 yr) | 92.7 (2 yr) | 93.2 (2 yr) | 5.3 | 9.1 | 0.5 (grade 3) | 0 | - |
Zhang |
48 (41.7-58) | 100 (cetuximab) | 95.2 (2 yr) | 88.1 (2 yr) | 93 (2 yr) | 7 (grade3) | 81.4 (grade3) | - | - | - |
Our Study | 33 (25-41) | 100 | 94 (2 yr) | 96 (2 yr) | 99 (2 yr) | 5 | 37 (grade3) | 51 (grade 3) | - | 5 (grade 3) |
CCRT = concurrent chemoradiotherapy; DMFS = distant metastasis free survival; LRFFS = locoregional failure free survival; M = month; 0S = overall survival; Yr = year
Dosimetric parameters related to conformity, homogeneity and organ at risk (OAR) sparing are presented in Table 1. All helical tomotherapy plans showed satisfactory conformity index and homogeneity index, being 0.89 ± 0.13 and 0.06 ± 0.07, respectively. Mean ± SD of D2% of spinal cord and brainstem were 34.1 ± 4.4 and 53.3 ± 6.3 Gy. Mean ± SD of D50 of contralateral and ipsilateral parotid gland were 28.4 ± 6.7 and 38.5 ± 11.2 Gy. The mean beam on time was 3.91 minutes (range = 3.53–4.21 minutes).
Several studies have shown the benefits of IMRT, which can reduce dose to the surrounding organs at risk, mainly the parotids, and also allows for dose escalation to the tumour.10-14 The use of daily image-guided radiotherapy (IGRT) is necessary in locally advanced nasopharyngeal carcinoma patients in order to reduce marginal miss due to the very steep dose gradients towards the critical structures.15
Helical tomotherapy integrates both techniques, IMRT and IGRT, in one machine. Although randomized studies16-20 found level 1 evidence of superiority of static beam IMRT over classical 2- and 3-dimensional RT in terms of xerostomia, such evidence is missing for the rotational IMRT techniques, Helical tomotherapy being one of them. So clinical evidence is warranted. The study from Leung
We considered the parotid glands as the most important OARs in regard to quality of life of our patients. We followed RTOG 0225 protocol7 in that the mean dose less than or equal to 26 Gy should be achieved in at least 1 gland. This could reduce the degree of xerostomia and therefore we tried to keep the Dmean under 26 Gy whenever possible. Helical tomotherapy offered very good preservation of this organ as also shown by Van Gestel
It has been reported that helical tomotherapy provided excellent conformity and homogeneity index in the treatment of nasopharyngeal carcinoma and other head and neck cancers.21-23 We achieved excellent dose coverage of the three PTVs with homogeneity index and conformity index comparable to the other studies.
We conclude that helical tomotherapy achieved good target coverage in nasopharyngeal cancer patients with favorable dose profile to most of OARs. As such helical tomotherapy achieved favorable 2-year locoregional failure free survival, distant metastasis free survival, and overall survival, with an acceptable rate of moderate and severe acute toxicities, but minimal rate of late toxicities.
IC conceived and coordinated the study, analysed the data, and drafted the manuscript. SC, WN, SJ coordinated and analysed the study. ET, PK, WO, BS, PK, AC participated in acquisition of data. PT, PS performed the statistical analysis. DVG helped to draft the manuscript. All authors read and approved the final manuscript.