Open Access

Dosimetric predictors of treatment-related lymphopenia induced by palliative radiotherapy: predictive ability of dose-volume parameters based on body surface contour


Cite

Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 2011; 480: 480-9.MellmanICoukosGDranoffGCancer immunotherapy comes of ageNature201148048048910.1038/nature10673396723522193102Search in Google Scholar

Hiraoka K, Miyamoto M, Cho Y, Suzuoki M, Oshikiri T, Nakakubo Y, et al. Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma. Br J Cancer 2006; 94: 275-80.HiraokaKMiyamotoMChoYSuzuokiMOshikiriTNakakuboYConcurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinomaBr J Cancer20069427528010.1038/sj.bjc.6602934236110316421594Search in Google Scholar

Ohtani H. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer. Cancer Immun 2007; 7: 4.OhtaniHFocus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancerCancer Immun200774Search in Google Scholar

Lohr J, Ratliff T, Huppertz A, Ge Y, Dictus C, Ahmadi R, et al. Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-β. Clin Cancer Res 2011; 17: 4296-308.LohrJRatliffTHuppertzAGeYDictusCAhmadiREffector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-βClin Cancer Res2011174296430810.1158/1078-0432.CCR-10-255721478334Search in Google Scholar

Gu-Trantien C, Loi S, Garaud S, Equeter C, Libin M, de Wind A, et al. CD4+ follicular helper T cell infiltration predicts breast cancer survival. J Clin Invest 2013; 123: 2873-92.Gu-TrantienCLoiSGaraudSEqueterCLibinMde WindACD4+ follicular helper T cell infiltration predicts breast cancer survivalJ Clin Invest20131232873289210.1172/JCI67428369655623778140Search in Google Scholar

Le Scodan R, Massard C, Mouret-Fourme E, Guinebretierre JM, Cohen-Solal C, De Lalande B, et al. Brain metastases from breast carcinoma: Validation of the radiation therapy oncology group recursive partitioning analysis classification and proposition of a new prognostic score. Int J Radiat Oncol Biol Phys 2007; 69: 839-45.Le ScodanRMassardCMouret-FourmeEGuinebretierreJMCohen-SolalCDe LalandeBBrain metastases from breast carcinoma: Validation of the radiation therapy oncology group recursive partitioning analysis classification and proposition of a new prognostic scoreInt J Radiat Oncol Biol Phys20076983984510.1016/j.ijrobp.2007.04.02417544592Search in Google Scholar

Fumagalli LA, Vinke J, Hoff W, Ypma E, Brivio F, Nespoli A. Lymphocyte counts independently predict overall survival in advanced cancer patients: A biomarker for IL-2 immunotherapy. J Immunother 2003; 26: 394-402.FumagalliLAVinkeJHoffWYpmaEBrivioFNespoliALymphocyte counts independently predict overall survival in advanced cancer patients: A biomarker for IL-2 immunotherapyJ Immunother20032639440210.1097/00002371-200309000-0000212973028Search in Google Scholar

De Giorgi U, Rihawi K, Aieta M, Lo Re G, Sava T, Masini C, et al. Lymphopenia and clinical outcome of elderly patients treated with sunitinib for metastatic renal cell cancer. J Geriatr Oncol 2014; 5: 156-63.De GiorgiURihawiKAietaMLo ReGSavaTMasiniCLymphopenia and clinical outcome of elderly patients treated with sunitinib for metastatic renal cell cancerJ Geriatr Oncol2014515616310.1016/j.jgo.2014.01.00124495699Search in Google Scholar

Jin Y, Ye X, He C, Zhang B, Zhang Y. Pretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinoma. Head Neck 2015; 37: 69-75.JinYYeXHeCZhangBZhangYPretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinomaHead Neck201537697510.1002/hed.2356524327524Search in Google Scholar

Feng J, Wang Z, Guo X, Chen Y, Cheng Y, Tang Y. Prognostic significance of absolute lymphocyte count at diagnosis of diffuse large B-cell lymphoma: A meta-analysis. Int J Hematol 2012; 95: 143-8.FengJWangZGuoXChenYChengYTangYPrognostic significance of absolute lymphocyte count at diagnosis of diffuse large B-cell lymphoma: A meta-analysisInt J Hematol20129514314810.1007/s12185-011-0993-622205504Search in Google Scholar

Balmanoukian A, Ye X, Herman J, Laheru D, Grossman SA. The association between treatment-related lymphopenia and survival in newly diagnosed patients with resected adenocarcinoma of the pancreas. Cancer Invest 2012; 30: 571-6.BalmanoukianAYeXHermanJLaheruDGrossmanSAThe association between treatment-related lymphopenia and survival in newly diagnosed patients with resected adenocarcinoma of the pancreasCancer Invest20123057157610.3109/07357907.2012.700987355750622812722Search in Google Scholar

Wild AT, Ye X, Ellsworth SG, Smith JA, Narang AK, Garg T, et al. The association between chemoradiation-related lymphopenia and clinical outcomes in patients with locally advanced pancreatic adenocarcinoma. Am J Clin Oncol 2015; 38: 259-65.WildATYeXEllsworthSGSmithJANarangAKGargTThe association between chemoradiation-related lymphopenia and clinical outcomes in patients with locally advanced pancreatic adenocarcinomaAm J Clin Oncol20153825926510.1097/COC.0b013e3182940ff9Search in Google Scholar

Wild AT, Herman JM, Dholakia AS, Moningi S, Lu Y, Rosati LM, et al. Lymphocyte-sparing effect of stereotactic body radiation therapy in patients with unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 2016; 94: 571-9.WildATHermanJMDholakiaASMoningiSLuYRosatiLMLymphocyte-sparing effect of stereotactic body radiation therapy in patients with unresectable pancreatic cancerInt J Radiat Oncol Biol Phys20169457157910.1016/j.ijrobp.2015.11.026Search in Google Scholar

Tang C, Liao Z, Gomez D, Levy L, Zhuang Y, Gebremichael RA, et al. Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes. Int J Radiat Oncol Biol Phys 2014; 89: 1084-91.TangCLiaoZGomezDLevyLZhuangYGebremichaelRALymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomesInt J Radiat Oncol Biol Phys2014891084109110.1016/j.ijrobp.2014.04.025Search in Google Scholar

Wu ES, Oduyebo T, Cobb LP, Cholakian D, Kong X, Fader AN, et al. Lymphopenia and its association with survival in patients with locally advanced cervical cancer. Gynecol Oncol 2016; 140: 76-82.WuESOduyeboTCobbLPCholakianDKongXFaderANLymphopenia and its association with survival in patients with locally advanced cervical cancerGynecol Oncol2016140768210.1016/j.ygyno.2015.11.013Search in Google Scholar

Grossman SA, Ye X, Lesser G, Sloan A, Carraway H, Desideri S, et al. Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide. Clin Cancer Res 2011; 17: 5473-80.GrossmanSAYeXLesserGSloanACarrawayHDesideriSImmunosuppression in patients with high-grade gliomas treated with radiation and temozolomideClin Cancer Res2011175473548010.1158/1078-0432.CCR-11-0774Search in Google Scholar

Mendez JS, Govindan A, Leong J, Gao F, Huang J, Campian JL. Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma. J Neurooncol 2016; 127: 329-35.MendezJSGovindanALeongJGaoFHuangJCampianJLAssociation between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastomaJ Neurooncol201612732933510.1007/s11060-015-2037-1Search in Google Scholar

Cho O, Oh YT, Chun M, Noh OK, Hoe JS, Kim H. Minimum absolute lymphocyte count during radiotherapy as a new prognostic factor for nasopharyngeal cancer. Head Neck 2016; 38 (Suppl 1): E1061-7.ChoOOhYTChunMNohOKHoeJSKimHMinimum absolute lymphocyte count during radiotherapy as a new prognostic factor for nasopharyngeal cancerHead Neck201638Suppl 1E1061E106710.1002/hed.24158Search in Google Scholar

Raben M, Walach N, Galili U, Schlesinger M. The effect of radiation therapy on lymphocyte subpopulations in cancer patients. Cancer 1976; 37: 141721.RabenMWalachNGaliliUSchlesingerMThe effect of radiation therapy on lymphocyte subpopulations in cancer patientsCancer1976371417142110.1002/1097-0142(197603)37:3<1417::AID-CNCR2820370324>3.0.CO;2-NSearch in Google Scholar

Yovino S, Kleinberg L, Grossman SA, Narayanan M, Ford E. The etiology of treatment-related lymphopenia in patients with malignant gliomas: Modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells. Cancer Invest 2013; 31: 140-4.YovinoSKleinbergLGrossmanSANarayananMFordEThe etiology of treatment-related lymphopenia in patients with malignant gliomas: Modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cellsCancer Invest20133114014410.3109/07357907.2012.762780Search in Google Scholar

Huang J, DeWees TA, Badiyan SN, Speirs CK, Mullen OF, Fergus S, et al. Clinical and dosimetric predictors of acute severe lymphopenia during radiation therapy and concurrent temozolomide for high-grade glioma. Int J Radiat Oncol Biol Phys 2015; 92: 1000-7.HuangJDeWeesTABadiyanSNSpeirsCKMullenOFFergusSClinical and dosimetric predictors of acute severe lymphopenia during radiation therapy and concurrent temozolomide for high-grade gliomaInt J Radiat Oncol Biol Phys2015921000100710.1016/j.ijrobp.2015.04.005Search in Google Scholar

Trowell OA. The sensitivity of lymphocytes to ionising radiation. J Pathol Bacteriol 1952; 64: 687-704.TrowellOAThe sensitivity of lymphocytes to ionising radiationJ Pathol Bacteriol19526468770410.1002/path.1700640403Search in Google Scholar

Nakamura N, Kusunoki Y, Akiyama M. Radiosensitivity of CD4 or CD8 positive human T-lymphocytes by an in vitro colony formation assay. Radiat Res 1990; 123: 224-7.NakamuraNKusunokiYAkiyamaMRadiosensitivity of CD4 or CD8 positive human T-lymphocytes by an in vitro colony formation assayRadiat Res199012322422710.2307/3577549Search in Google Scholar

Campbell BA, Callahan J, Bressel M, Simoens N, Everitt S, Hofman MS, et al. Distribution atlas of proliferating bone marrow in non-small cell lung cancer patients measured by FLT-PET/CT imaging, with potential applicability in radiation therapy planning. Int J Radiat Oncol Biol Phys 2015; 92: 1035-43.CampbellBACallahanJBresselMSimoensNEverittSHofmanMSDistribution atlas of proliferating bone marrow in non-small cell lung cancer patients measured by FLT-PET/CT imaging, with potential applicability in radiation therapy planningInt J Radiat Oncol Biol Phys2015921035104310.1016/j.ijrobp.2015.04.027Search in Google Scholar

Campbell AC, Hersey P, MacLennan IC, Kay HE, Pike MC. Immunosuppressive consequences of radiotherapy and chemotherapy in patients with acute lymphoblastic leukaemia. Br Med J 1973; 2: 385-8.CampbellACHerseyPMacLennanICKayHEPikeMCImmunosuppressive consequences of radiotherapy and chemotherapy in patients with acute lymphoblastic leukaemiaBr Med J1973238538810.1136/bmj.2.5863.385Search in Google Scholar

Weeke E. The development of lymphopenia in uremic patients undergoing extracorporeal irradiation of the blood with portable beta units. Radiat Res 1973; 56: 554-9.WeekeEThe development of lymphopenia in uremic patients undergoing extracorporeal irradiation of the blood with portable beta unitsRadiat Res19735655455910.2307/3573724Search in Google Scholar

Boehm T, Bleul CC. The evolutionary history of lymphoid organs. Nat Immunol 2007; 8: 131-5.BoehmTBleulCCThe evolutionary history of lymphoid organsNat Immunol2007813113510.1038/ni1435Search in Google Scholar

Sini C, Fiorino C, Perna L, Noris Chiorda B, Deantoni CL, Bianchi M, et al. Dose-volume effects for pelvic bone marrow in predicting hematological toxicity in prostate cancer radiotherapy with pelvic node irradiation. Radiother Oncol 2016; 118: 79-84.SiniCFiorinoCPernaLNoris ChiordaBDeantoniCLBianchiMDose-volume effects for pelvic bone marrow in predicting hematological toxicity in prostate cancer radiotherapy with pelvic node irradiationRadiother Oncol201611817918410.1016/j.radonc.2015.11.020Search in Google Scholar

MacLennan IC, Kay HE. Analysis of treatment in childhood leukemia. IV. The critical association between dose fractionation and immunosuppression induced by cranial irradiation. Cancer 1978; 41: 108-11.MacLennanICKayHEAnalysis of treatment in childhood leukemia. IV. The critical association between dose fractionation and immunosuppression induced by cranial irradiationCancer19784110811110.1002/1097-0142(197801)41:1<108::AID-CNCR2820410116>3.0.CO;2-ZSearch in Google Scholar

eISSN:
1581-3207
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Radiology, Internal Medicine, Haematology, Oncology