Myeloma patients account for about ten percent of patients presenting with malignant spinal cord compression (SCC).1 Radiotherapy (RT) alone is the most frequently used treatment for these patients worldwide. Ten years ago, a small randomized trial of 101 patients was published that compared RT alone to decompressive surgery plus stabilization followed by RT in highly selected patients.2 In that trial the combined approach resulted in significantly better functional outcome (ambulation) and survival than irradiation alone. Therefore, upfront neurosurgery has become significantly more popular in several countries. Although patients with highly radiosensitive tumors such as myeloma, lymphoma and germ cell tumors were excluded from the randomized trial of 101 patients, many neurosurgeons extrapolated from these findings and perform decompressive surgery in myeloma patients.2 The question remains whether RT alone is sufficient or needs to be supplemented by upfront decompressive surgery in malignant SCC from a highly radiosensitive tumor. This study aims to contribute to this open question by investigating overall response and local control of SCC in patients treated with RT alone for SCC from myeloma.
Data of 238 patients presenting with motor deficits of the lower extremities in consequence of SCC from vertebral body myeloma were retrospectively analyzed. Prior to the start of RT, the patients were presented to a neurosurgeon for evaluation whether upfront decompressive surgery was indicated,
The primary endpoint local control was defined as freedom from a symptomatic in-field recurrence of SCC in the irradiated parts of the vertebral column. In addition, the effect of radiation treatment on motor function (improvement, no further progression, deterioration) was measured. Improvement and deterioration of motor function were defined as a change of one point on a fivepoint scale (0 = normal strength; 1 = ambulation without aid; 2 = ambulation with aid; 3 = no ambulation; 4 = complete paraplegia).3 Patients with complete paraplegia who did not improve after RT were rated as deteriorated. Motor function at about one month (three to six weeks) following RT was compared to motor function at baseline (
RT was administered without upfront neurosurgery and performed either as short-course RT (1 x 8Gy, 5 x 4Gy) or longer-course RT (10 x 3Gy, 15 x 2.5Gy, 20 x 2Gy). The RT regimen plus ten other factors were analyzed for local control of SCC. The other factors included age at the time of RT (≤ 64 years
Two-hundred-and-thirty-seven patients were available for evaluation of response to RT. The overall response rate at one month was 97% (230 of 237 patients); 53% of patients (n = 126) showed improvement and 44% (n = 104) no further progression. Following RT, 88% of the patients (209 of 237) were able to walk. Of 69 non-ambulatory patients 44 patients (64%) regained the ability to walk after RT.
In the entire cohort of 238 patients, the local control rates at 1, 2 and 3 years following RT of SCC were 93%, 82% and 82%, respectively. In the univariate analysis, no factor was significantly associated with local control of SCC. A trend towards better local control was observed for patients who were ambulatory before RT was started (p = 0.08, Figure 1) and for patients with a more favorable performance status (p = 0.07, Figure 2). These two factors were additionally evaluated in the multivariate analysis, where both pre-RT gait function (risk ratio: 2.34; 95%-confidence interval: 0.80–6.10; p = 0.11) and performance status (risk ratio: 2.36; 95%-confidence interval: 0.85– 6.09; p = 0.09) did not reach significance (significance = defined as p < 0.05).
Malignant SCC represents a serious complication for patients with a malignant disease.1,5 A rapid start of treatment is required. Until 2005, radiotherapy alone has been considered the unquestioned standard treatment for SCC. In 2005, a randomized trial of 101 selected patients with SCC from different primaries, who had a good performance status and a relatively good survival prognosis, suggested that the results of RT alone can be improved by upfront decompressive surgery.2 In that trial, 84% (42 of 50) of patients were able to walk after surgery plus RT compared to 57% (29 of 51) of patients after RT alone (p = 0.001). The results were supported by a meta-analysis including 24 surgical series (n = 999) and four radiotherapy series (n = 543), mostly uncontrolled cohort studies.6 These data have led to a fundamental change of practice. In several countries, neurosurgery proceeding RT has become very popular. In some centers, the majority patients with SCC receive the combined treatment rather than RT alone. This new trend includes also patients with highly radiosensitive tumors such as myeloma, although these patients were excluded from the previously mentioned randomized trial.2 The question is whether these patients really need surgery in addition to RT? One should bear in mind that spinal surgery is associated with significant risks and complications such as severe wound infections. A second surgery, extensive bleeding, postoperative pneumonia, and major thromboembolic events occurred in more than 10% of patients. 2,7,8 In addition, iatrogenic neurologic complications were reported for 9% of patients receiving surgery of the lumbar spine.9
In the current study, functional outcomes were excellent with a post-RT overall ambulation rate of 88% and a rate of regaining ambulatory status of 64%. Furthermore, local control of SCC achieved with RT alone was long lasting. At 3 years following RT, local control was still 82%. These excellent local control rates were achieved irrespectively of patient characteristics. None of the eleven investigated characteristics was significantly associated with local control of SCC. However, pre-RT gait function and performance status showed a trend. Three-year local control rates were 57% in initially non-ambulatory patients and 62% in patients with an ECOG performance score of 3–4, respectively. The question whether these patients would benefit from the addition of upfront decompressive surgery to RT can be properly answered only in a prospective trial. Clear indications for neurosurgery also for very radiosensitive tumors include vertebral fractures, unstable spine, sphincter dysfunction, and impairment of the spinal cord by bony fragments. According to a recent retrospective study focusing on surgery for vertebral involvement of myeloma, the probability of receiving surgery was about 40%.10 No differences in disability and quality of life were observed between patients receiving RT alone and those receiving RT plus upfront surgery. For highly selected patients, stereotactic body radiation surgery (SBRT) may also be an option.11,12 However, it has been recommended to use SBRT for malignant SCC only within clinical trials.12
In summary, in patients with malignant SCC from myeloma, RT alone provides excellent response rates, functional outcomes such as post-RT ambulation, and local control of SCC. These results should be confirmed in a prospective randomized trial.
Impact of the eleven factors on local control of SCC (univariate analysis)
Age | ||||
≤ 64 years (n = 125) | 94 | 86 | 86 | |
≥ 65 years (n = 113) | 92 | 75 | 75 | 0.81 |
Gender | ||||
Female (n = 88) | 90 | 78 | 78 | |
Male (n = 150) | 94 | 85 | 85 | 0.47 |
Myeloma subtype | ||||
IgG subtype (n = 153) | 96 | 84 | 84 | |
Other subtypes (n = 85) | 88 | 78 | 78 | 0.14 |
Time from myeloma diagnosis to SCC | ||||
≤ 15 months (n = 128) | 95 | 81 | 81 | |
> 15 months (n = 110) | 91 | 85 | 85 | 0.83 |
Extra-osseous lesions | ||||
No (n = 218) | 94 | 82 | 82 | |
Yes (n = 20) | 67 | n.a. | n.a. | 0.19 |
Further osseous lesions | ||||
No (n = 91) | 93 | 86 | 86 | |
Yes (n = 147) | 93 | 76 | 76 | 0.73 |
Time developing motor deficits | ||||
Faster (≤ 14 days) (n = 112) | 93 | 81 | 81 | |
Slower (> 14 days = (n = 126) | 93 | 83 | 83 | 0.79 |
Gait function before the start of RT | ||||
Ambulatory (n = 169) | 95 | 85 | 85 | |
Not ambulatory (n = 69) | 85 | 57 | 57 | 0.08 |
Number of vertebrae involved by SCC | ||||
1-2 (n = 112) | 95 | 87 | 87 | |
≤ 3 (n = 126) | 92 | 77 | 77 | 0.17 |
ECOG performance score | ||||
1-2 (n = 150) | 96 | 86 | 86 | |
3-4 (n = 88) | 83 | 62 | 62 | 0.07 |
Radiotherapy regimen | ||||
Short-course RT (n = 84) | 94 | 69 | 69 | |
Longer-course RT (n = 154) | 93 | 90 | 90 | 0.29 |
Entire cohort (n = 238) | 93 | 82 | 82 |