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Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia AS, McNamara JO, et al. Neuroscience (2nd edition) Sunderland (MA): Sinauer Associates; 2001.PurvesDAugustineGJFitzpatrickDKatzLCLaMantiaASMcNamaraJOet alSunderland (MA)Sinauer Associates2001Search in Google Scholar
Park JK, Hodges T, Arko L, Shen M, Dello Iacono D, McNabb A, et al. Scale to predict survival after surgery for recurrent glioblastoma multiforme. J Clin Oncol 2010; 28: 3838-43.ParkJKHodgesTArkoLShenMDello IaconoDMcNabbAet alScale to predict survival after surgery for recurrent glioblastoma multiforme20102838384310.1200/JCO.2010.30.0582Search in Google Scholar
Chaichana KL, McGirt MJ, Laterra J, Olivi A, Quiñones-Hinojosa A. Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas. J Neurosurg 2010; 112: 10-7.ChaichanaKLMcGirtMJLaterraJOliviAQuiñones-HinojosaARecurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas201011210710.3171/2008.10.JNS08608Search in Google Scholar
Wick W, Stupp R, Beule AC, Bromberg J, Wick A, Ernemann U, et al. A novel tool to analyze MRI recurrence patterns in glioblastoma. Neuro Oncol 2008; 10: 1019-24.WickWStuppRBeuleACBrombergJWickAErnemannUet alA novel tool to analyze MRI recurrence patterns in glioblastoma20081010192410.1215/15228517-2008-058Search in Google Scholar
Barajas RF Jr, Chang JS, Segal MR, Parsa AT, McDermott MW, Berger MS, et al. Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2009; 253:486-96.BarajasRFJrChangJSSegalMRParsaATMcDermottMWBergerMSet alDifferentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging20092534869610.1148/radiol.2532090007Search in Google Scholar
Fatterpekar GM, Galheigo D, Narayana A, Johnson G, Knopp E. Treatment-related change versus tumor recurrence in high-grade gliomas: a diagnostic conundrum--use of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI. AJR Am J Roentgenol 2012; 198: 19-26.FatterpekarGMGalheigoDNarayanaAJohnsonGKnoppETreatment-related change versus tumor recurrence in high-grade gliomas: a diagnostic conundrum--use of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI2012198192610.2214/AJR.11.7417Search in Google Scholar
Patronas NJ, Di Chiro G, Brooks RA, DeLaPaz RL, Kornblith PL, Smith BH, et al. Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology 1982; 144: 885-9.PatronasNJDi ChiroGBrooksRADeLaPazRLKornblithPLSmithBHet alWork in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain1982144885910.1148/radiology.144.4.6981123Search in Google Scholar
Di Chiro G, Oldfield E, Wright DC, De Michele D, Katz DA, Patronas NJ, et al. Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies. AJR Am J Roentgenol 1988; 150: 189-97.Di ChiroGOldfieldEWrightDCDeMicheleDKatzDAPatronasNJet alCerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies19881501899710.2214/ajr.150.1.189Search in Google Scholar
Wong TZ, van der Westhuizen GJ, Coleman RE. Positron emission tomography imaging of brain tumors. Neuroimaging Clin N Am 2002; 12: 615-26.WongTZvan der WesthuizenGJColemanREPositron emission tomography imaging of brain tumors2002126152610.1016/S1052-5149(02)00033-3Search in Google Scholar
Olivero WC, Dulebohn SC, Lister JR. The use of PET in evaluating patients with primary brain tumors: Is it useful? J Neurol Neurosurg Psychiatry 1995; 58: 250-2.OliveroWCDulebohnSCListerJRThe use of PET in evaluating patients with primary brain tumors: Is it useful?199558250210.1136/jnnp.58.2.250Search in Google Scholar
Ramirez de Molina A, Rodriguez-Gonzalez A, Gutierrez R, Martinez-Pineiro L, Sanchez J, Bonilla F. Overexpression of choline kinase is a frequent feature in human tumor derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun 2000; 296: 580-3.Ramirez de MolinaARodriguez-GonzalezAGutierrezRMartinez-PineiroLSanchezJBonillaFOverexpression of choline kinase is a frequent feature in human tumor derived cell lines and in lung, prostate, and colorectal human cancers2000296580310.1016/S0006-291X(02)00920-8Search in Google Scholar
Shinoura N, Nishijima M, Hara T, Haisa T, Yamamoto H, Fujii K. Brain tumors: detection with C-11 choline PET. Radiology 1997; 202: 497–503.ShinouraNNishijimaMHaraTHaisaTYamamotoHFujiiKBrain tumors: detection with C-11 choline PET199720249750310.1148/radiology.202.2.9015080Search in Google Scholar
Sollini M, Sghedoni R, Erba PA, Cavuto S, Froio A, De Berti G, et al. Diagnostic performances of [18F]fluorocholine positron emission tomography in brain tumors. Q J Nucl Med Mol Imaging 2015; Sep 1 [Epub ahead of print]; PMID: 26329494.SolliniMSghedoniRErbaPACavutoSFroioADe BertiGet alDiagnostic performances of [18F]fluorocholine positron emission tomography in brain tumors2015Sep 1 [Epub ahead of print]; PMID: 2632949410.23736/S1824-4785.17.02807-2Search in Google Scholar
Friedland RP, Mathis CA, Budinger TF. Labelled choline and phosphorycholine: Body distribution and brain autoradiography. J Nucl Med 1983; 24:812-5.FriedlandRPMathisCABudingerTFLabelled choline and phosphorycholine: Body distribution and brain autoradiography1983248125Search in Google Scholar
Wyss MT, Weber B, Honer M, Späth N, Ametamey SM, Westera G, et al. 18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET. Eur J Nucl Med Mol Imaging 2004; 3: 312-6.WyssMTWeberBHonerMSpäthNAmetameySMWesteraGet al18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET20043312610.1007/s00259-003-1337-4Search in Google Scholar
Oxender DL, Christensen HN. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell. J Biol Chem 1963; 238: 3686-99.OxenderDLChristensenHNDistinct mediating systems for the transport of neutral amino acids by the Ehrlich cell196323836869910.1016/S0021-9258(19)75327-7Search in Google Scholar
Kaim AH, Weber B, Kurrer MO, Westera G, Schweitzer A, Gottschalk J, et al. 18F-FDG and 18F-FET uptake in experimental soft tissue infection. Eur J Nucl Med 2002; 29: 648-54.KaimAHWeberBKurrerMOWesteraGSchweitzerAGottschalkJet al18F-FDG and 18F-FET uptake in experimental soft tissue infection2002296485410.1007/s00259-002-0780-y11976803Search in Google Scholar
Buck D, Förschler A, Lapa C, Schuster T, Vollmar P, Korn T, et al. 18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesions. J Nucl Med 2012; 53: 1269-76.BuckDFörschlerALapaCSchusterTVollmarPKornTet al18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesions20125312697610.2967/jnumed.111.10260822738927Search in Google Scholar
Messing-Jünger AM, Floeth FW, Pauleit D, Reifenberger G, Willing R, Gärtner J, et al. Multimodal target point assessment for stereo-tactic biopsy in children with diffuse bithalamic astrocytomas. Child’s Nerv Syst 2002; 18:445-9.Messing-JüngerAMFloethFWPauleitDReifenbergerGWillingRGärtnerJet alMultimodal target point assessment for stereo-tactic biopsy in children with diffuse bithalamic astrocytomas200218445910.1007/s00381-002-0644-612192504Search in Google Scholar
Pauleit D, Floeth F, Tellmann L, Hamacher K, Hautzel H, Müller HW, et al. Comparison of O-(2-18F-fluoroethyl)-L-tyrosine PET and 3-123I-iodo-alphamethyl-L-tyrosine SPECT in brain tumors. J Nucl Med 2004; 45: 374-81.PauleitDFloethFTellmannLHamacherKHautzelHMüllerHWet alComparison of O-(2-18F-fluoroethyl)-L-tyrosine PET and 3-123I-iodo-alphamethyl-L-tyrosine SPECT in brain tumors20044537481Search in Google Scholar
Pöpperl G, Goldbrunner R, Gildehaus FJ, Kreth FW, Tanner P, Holtmannspötter M, et al. O-(2-(18F)fluoroethyl)-L-tyrosine PET for monitoring the effects of convection-enhanced delivery of paclitaxel in patients with recurrent glioblastoma. Eur J Nucl Med Mol Imaging 2005; 32: 1018-25.PöpperlGGoldbrunnerRGildehausFJKrethFWTannerPHoltmannspötterMet alO-(2-(18F)fluoroethyl)-L-tyrosine PET for monitoring the effects of convection-enhanced delivery of paclitaxel in patients with recurrent glioblastoma20053210182510.1007/s00259-005-1819-715877226Search in Google Scholar
Pöpperl G, Götz C, Rachinger W, Schnell O, Gildehaus FJ, Tonn JC, et al. Serial O-(2-[(18)F]fluoroethyl)-L:-tyrosine PET for monitoring the effects of intracavitary radioimmunotherapy in patients with malignant glioma. Eur J Nucl Med Mol Imaging 2006; 33: 792-800.PöpperlGGötzCRachingerWSchnellOGildehausFJTonnJCet alSerial O-(2-[(18)F]fluoroethyl)-L:-tyrosine PET for monitoring the effects of intracavitary radioimmunotherapy in patients with malignant glioma20063379280010.1007/s00259-005-0053-7199888916550381Search in Google Scholar
Piroth MD, Pinkawa M, Holy R, Klotz J, Nussen S, Stoffels G, et al. Prognostic value of early [18F]fluoroethyltyrosine positron emission tomography after radiochemotherapy in glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2011; 30: 176-84.PirothMDPinkawaMHolyRKlotzJNussenSStoffelsGet alPrognostic value of early [18F]fluoroethyltyrosine positron emission tomography after radiochemotherapy in glioblastoma multiforme2011301768410.1016/j.ijrobp.2010.01.05520646863Search in Google Scholar
Wyss M, Hofer S, Bruehlmeier M, Hefti M, Uhlmann C, Bärtschi E, et al. Early metabolic responses in temozolomide treated low-grade glioma patients. J Neurooncol 2009; 95: 87-93.WyssMHoferSBruehlmeierMHeftiMUhlmannCBärtschiEet alEarly metabolic responses in temozolomide treated low-grade glioma patients200995879310.1007/s11060-009-9896-219381442Search in Google Scholar
Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 2003; 98: 378-84.YaoKCKomataTKondoYKanzawaTKondoSGermanoIMMolecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy2003983788410.3171/jns.2003.98.2.037812593626Search in Google Scholar
Stein GH. T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro. J Cell Physiol 1979; 99: 43-54.SteinGHT98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro197999435410.1002/jcp.1040990107222778Search in Google Scholar
Buroni FE, Pasi F, Persico MG, Lodola L, Aprile C, Nano R. Evidence of 18F-FCH uptake in human T98G glioblastoma cell line. Anticancer Res 2015; 35: 64438.BuroniFEPasiFPersicoMGLodolaLAprileCNanoREvidence of 18F-FCH uptake in human T98G glioblastoma cell line20153564438Search in Google Scholar
Wyss MT, Spaeth N, Biollaz G, Pahnke J, Alessi P, Trachsel E, Treyer V, et al. Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis. J Nucl Med 2007; 48:608-14.WyssMTSpaethNBiollazGPahnkeJAlessiPTrachselETreyerVet alUptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis2007486081410.2967/jnumed.106.03625117401099Search in Google Scholar
Spaeth N, Wyss MT, Pahnke J, Biollaz G, Lutz A, Goepfert K, et al. Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L:-tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat. Eur J Nucl Med Mol Imaging 2006; 33: 673-82.SpaethNWyssMTPahnkeJBiollazGLutzAGoepfertKet alUptake of 18F-fluorocholine, 18F-fluoro-ethyl-L:-tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat2006336738210.1007/s00259-005-0045-716538503Search in Google Scholar
Bolcaen J, Descamps B, Deblaere K, Boterberg T, De Vos Pharm F, Kalala JP, et al. (18)F-fluoromethylcholine (FCho), (18)F-fluoroethyltyrosine (FET), and (18)F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: a PET study. Nucl Med Biol 2015; 42:38-45.BolcaenJDescampsBDeblaereKBoterbergTDe Vos PharmFKalalaJPet al(18)F-fluoromethylcholine (FCho), (18)F-fluoroethyltyrosine (FET), and (18)F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: a PET study201542384510.1016/j.nucmedbio.2014.07.00625218024Search in Google Scholar
Wang L, Lieberman BP, Ploessl K, Kung HF. Synthesis and evaluation of 18F labelled FET prodrugs for tumor imaging. Nucl Med Biol 2014; 41: 58-67.WangLLiebermanBPPloesslKKungHFSynthesis and evaluation of 18F labelled FET prodrugs for tumor imaging201441586710.1016/j.nucmedbio.2013.09.011389594524183614Search in Google Scholar
Wang HE, Wu SY, Chang CW, Liu RS, Hwang LC, Lee TW, et al. Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model. Nucl Med Biol 2005; 32: 367-75.WangHEWuSYChangCWLiuRSHwangLCLeeTWet alEvaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model2005323677510.1016/j.nucmedbio.2005.01.00515878506Search in Google Scholar
Habermeier A, Graf J, Sandhöfer BF, Boissel JP, Roesch F, Closs EI. System L amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-L-tyrosine (FET). Amino Acids 2015; 47: 335-44.HabermeierAGrafJSandhöferBFBoisselJPRoeschFClossEISystem L amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-L-tyrosine (FET)2015473354410.1007/s00726-014-1863-325385314Search in Google Scholar
Heiss P, Mayer S, Herz M, Wester HJ, Schwaiger M, Senekowitsch-Schmidtke R. Investigation of transport mechanism and uptake kinetics of O-(2-[18F] fluoroethyl)-L-tyrosine in vitro and in vivo. J Nucl Med 1999; 40: 1367-73.HeissPMayerSHerzMWesterHJSchwaigerMSenekowitsch-SchmidtkeRInvestigation of transport mechanism and uptake kinetics of O-(2-[18F] fluoroethyl)-L-tyrosine in vitro and in vivo199940136773Search in Google Scholar
Bansal A, Shuyan W, Hara T, Harris RA, Degrado TR. Biodisposition and metabolism of [(18)F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats. Eur J Nucl Med Mol Imaging 2008; 35: 1192-203.BansalAShuyanWHaraTHarrisRADegradoTRBiodisposition and metabolism of [(18)F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats200835119220310.1007/s00259-008-0736-y238698018264706Search in Google Scholar
Stöber B, Tanase U, Herz M, Seidl C, Schwaiger M, Senekowitsch-Schmidtke R. Differentiation of tumour and inflammation: characterisation of [methyl3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells. Eur J Nucl Med Mol Imaging 2006; 33: 932-9.StöberBTanaseUHerzMSeidlCSchwaigerMSenekowitsch-SchmidtkeRDifferentiation of tumour and inflammation: characterisation of [methyl3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells200633932910.1007/s00259-005-0047-516604346Search in Google Scholar
van Waarde A, Elsinga PH. Proliferation markers for the differential diagnosis of tumor and inflammation. Curr Pharm Des. 2008; 14: 3326-39.van WaardeAElsingaPHProliferation markers for the differential diagnosis of tumor and inflammation20081433263910.2174/13816120878654939919075707Search in Google Scholar
Langen KJ, Hamacher K, Weckesser M, Floeth F, Stoffels G, Bauer D, et al. O-(2-[18F]fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications. Nucl Med Biol 2006; 33: 287-94.LangenKJHamacherKWeckesserMFloethFStoffelsGBauerDet alO-(2-[18F]fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications2006332879410.1016/j.nucmedbio.2006.01.00216631076Search in Google Scholar
Spaeth N, Wyss MT, Weber B, Scheidegger S, Lutz A, Verwey J, et al. Uptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence. J Nucl Med 2004; 45: 1931-8.SpaethNWyssMTWeberBScheideggerSLutzAVerweyJet alUptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence20044519318Search in Google Scholar
Piroth MD, Prasath J, Willuweit A, Stoffels G, Sellhaus B, van Osterhout A, et al. Uptake of O-(2-[18F]fluoroethyl)-L-tyrosine in reactive astrocytosis in the vicinity of cerebral gliomas. Nucl Med Biol 2013; 40: 795-800.PirothMDPrasathJWilluweitAStoffelsGSellhausBvan OsterhoutAet alUptake of O-(2-[18F]fluoroethyl)-L-tyrosine in reactive astrocytosis in the vicinity of cerebral gliomas20134079580010.1016/j.nucmedbio.2013.05.00123769262Search in Google Scholar