<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2016-0021_s_025_w2aab3b8c10b1b7b1aab1c16b1Aa"><h3>Backgrounds</h3><p>Testicular cancer is the most common malignancy in young men. Considering increasing incidence, exceptionally high cure rate, as well as long life expectancy, assessment of long term toxicity in testicular cancer survivors is of great importance. In the last decades a major effort has been made in order to reduce toxicity of treatment, while maintaining its high effectiveness.</p></sec><sec id="j_raon-2016-0021_s_026_w2aab3b8c10b1b7b1aab1c16b2Aa"><h3>Conclusions</h3><p>Actual knowledge on treatment toxicity is based on outdated treatment modalities. Hopefully, modern treatment modalities could reduce toxicity, but, there is no firm confirmation for that at the moment, as data dealing with late sequelae of modern treatment of testicular cancer are not available yet due to the short period of observation. The life-threatening cardiovascular toxicity in testicular cancer survivors is major complication of platinum-based chemotherapy, mediastinal radiotherapy and even subdiaphragmatic radiotherapy.</p></sec></abstract>

BackgroundsTesticular cancer is the most common malignancy in young men. Considering increasing incidence, exceptionally high cure rate, as well as long life expectancy, assessment of long term toxicity in testicular cancer survivors is of great importance. In the last decades a major effort has been made in order to reduce toxicity of treatment, while maintaining its high effectiveness.ConclusionsActual knowledge on treatment toxicity is based on outdated treatment modalities. Hopefully, modern treatment modalities could reduce toxicity, but, there is no firm confirmation for that at the moment, as data dealing with late sequelae of modern treatment of testicular cancer are not available yet due to the short period of observation. The life-threatening cardiovascular toxicity in testicular cancer survivors is major complication of platinum-based chemotherapy, mediastinal radiotherapy and even subdiaphragmatic radiotherapy.

Treatment-related cardiovascular toxicity in long-term survivors of testicular cancer

Radiology and Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

BackgroundsTesticular cancer is the most common malignancy in young men. Considering increasing incidence, exceptionally high cure rate, as well as long life...

Treatment-related cardiovascular toxicity in long-term survivors of testicular cancer

Article Category: Review

Published Online: Apr 19, 2016

Page range: 221 - 227

Received: Feb 04, 2016

Accepted: Feb 14, 2016

DOI: https://doi.org/10.1515/raon-2016-0021

Keywords
testicular cancer, cardiovascular toxicity, long-term survivors

© 2017 Jasenka Gugic, Lorna Zadravec Zaletel, Irena Oblak

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Treatment-related cardiovascular toxicity in long-term survivors of testicular cancer

Article Category: Review

Published Online: Apr 19, 2016

Page range: 221 - 227

Received: Feb 04, 2016

Accepted: Feb 14, 2016

DOI: https://doi.org/10.1515/raon-2016-0021

Keywordstesticular cancer, cardiovascular toxicity, long-term survivors

© 2017 Jasenka Gugic, Lorna Zadravec Zaletel, Irena Oblak

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords
testicular cancer, cardiovascular toxicity, long-term survivors