<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses potentially pathogenic to the nervous system. Presence of anti-HHV-6 and -HHV-7 antibodies and viral genomic sequences, viral loads, HHV-6 variant-specificity, and TNF-α level were studied in 41 FM patients and 50 healthy individuals using polymerase chain reactions, restriction endonuclease analysis and ELISA. There was no difference in the presence of anti-HHV-6 and anti-HHV-7 IgG class antibodies between FM patients and control group individuals. Viral sequences were found in 80.5% of FM patients and in 62.0% of controls. Significantly higher rate of concurrent HHV-6 and HHV-7 infection and higher viral loads in peripheral blood were detected in FM patients compared to the control group individuals. Plasma viremia was detected only in FM patients. Significantly higher TNF-α levels were detected in virus positive FM patients. From all positive cases only in two FM patients HHV-6A was revealed. Significantly higher detection frequency of concurrent HHV-6 and HHV-7 infection, simultaneous HHV-6 and HHV-7 activation, higher viral loads and TNF-α expression levels in primary FM patients than in control group individuals indicate the potential involvement of Roseoloviruses in development of this disorder. </p></abstract>

Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses potentially pathogenic to the nervous system. Presence of anti-HHV-6 and -HHV-7 antibodies and viral genomic sequences, viral loads, HHV-6 variant-specificity, and TNF-α level were studied in 41 FM patients and 50 healthy individuals using polymerase chain reactions, restriction endonuclease analysis and ELISA. There was no difference in the presence of anti-HHV-6 and anti-HHV-7 IgG class antibodies between FM patients and control group individuals. Viral sequences were found in 80.5% of FM patients and in 62.0% of controls. Significantly higher rate of concurrent HHV-6 and HHV-7 infection and higher viral loads in peripheral blood were detected in FM patients compared to the control group individuals. Plasma viremia was detected only in FM patients. Significantly higher TNF-α levels were detected in virus positive FM patients. From all positive cases only in two FM patients HHV-6A was revealed. Significantly higher detection frequency of concurrent HHV-6 and HHV-7 infection, simultaneous HHV-6 and HHV-7 activation, higher viral loads and TNF-α expression levels in primary FM patients than in control group individuals indicate the potential involvement of Roseoloviruses in development of this disorder.

Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju

Augusts Kirhenšteins Institute of Microbiology and Virology, Rīga Stradiņš University, Rātsupītes iela 5, Rīga, LV-1067, LATVIA

Department of Neurology and Neurosurgery, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007, LATVIA

Depatment of Infectology and Dermatology, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease...

Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju

Published Online: Aug 04, 2016

Page range: 205 - 210

Received: Dec 04, 2015

DOI: https://doi.org/10.1515/prolas-2016-0032

Keywords
fibromyalgia, human herpesvirus-6, human herpesvirus-7, infection, molecular diagnostic

© by Svetlana Čapenko

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju

Published Online: Aug 04, 2016

Page range: 205 - 210

Received: Dec 04, 2015

DOI: https://doi.org/10.1515/prolas-2016-0032

Keywordsfibromyalgia, human herpesvirus-6, human herpesvirus-7, infection, molecular diagnostic

© by Svetlana Čapenko

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
fibromyalgia, human herpesvirus-6, human herpesvirus-7, infection, molecular diagnostic