<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The significance of carbohydrate (cancer) antigen 125 (Ca-125) and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of malignant and benign pleural effusion was studied. Within this prospective study, 121 patients with fluids of various aetiology in the pleural cavity were analysed. Malignant pleural effusion was detected in 55 patients, parapneumonic effusion in 28 patients, transudative effusion of cardiac origin in 31 patients, pancreatitis in one patient and tuberculous pleurisy in five patients. The highest accuracy in diagnosis of malignancy was observed for Ca-125 and CEA levels in the pleural fluid: 75.2% at cut-off value ≥1452 U/mL and 76.9% at cut-off value ≥6.58 ng/mL, respectively. We conclude that the level of tumour markers in pleural fluid has additional diagnostic significance in the differential diagnosis of malignant and benign pleural effusions. </p></abstract>

The significance of carbohydrate (cancer) antigen 125 (Ca-125) and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of malignant and benign pleural effusion was studied. Within this prospective study, 121 patients with fluids of various aetiology in the pleural cavity were analysed. Malignant pleural effusion was detected in 55 patients, parapneumonic effusion in 28 patients, transudative effusion of cardiac origin in 31 patients, pancreatitis in one patient and tuberculous pleurisy in five patients. The highest accuracy in diagnosis of malignancy was observed for Ca-125 and CEA levels in the pleural fluid: 75.2% at cut-off value ≥1452 U/mL and 76.9% at cut-off value ≥6.58 ng/mL, respectively. We conclude that the level of tumour markers in pleural fluid has additional diagnostic significance in the differential diagnosis of malignant and benign pleural effusions.

Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

Department of Pulmonology, Riga East Clinical University Hospital, Hipokrâta iela 2, Rîga, LV-1038, LATVIA

Department of Internal Diseases, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1017, LATVIA

Riga East Clinical University Hospital, Rīga, LV-1038, LATVIA

Faculty of Medicine, University of Latvia, Raiņa bulv. 19, Rīga, LV-1586, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The significance of carbohydrate (cancer) antigen 125 (Ca-125) and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of...

Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

Published Online: Jun 15, 2016

Page range: 41 - 46

Received: Aug 12, 2015

DOI: https://doi.org/10.1515/prolas-2016-0008

Keywords
pleural fluid, malignant effusion, tumour markers, CA-125, CEA

© by Dace Žentiņa

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

Published Online: Jun 15, 2016

Page range: 41 - 46

Received: Aug 12, 2015

DOI: https://doi.org/10.1515/prolas-2016-0008

Keywordspleural fluid, malignant effusion, tumour markers, CA-125, CEA

© by Dace Žentiņa

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
pleural fluid, malignant effusion, tumour markers, CA-125, CEA