<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In patients with chronic kidney disease the alterations of the endocrine system may arise from several causes. The kidney is the site of degradation as well as synthesis of many different hormones. Moreover, a number of concomitant pathological conditions such as inflammation, metabolic acidosis and malnutrition may participate in the pathogenesis of endocrine abnormalities in this group of patients. The most pronounced endocrine abnormalities in patients with chronic kidney disease are the deficiencies of: calcitriol, testosterone, insulin-like growth factor and, erythropoietin (EPO). Additionally accumulation of several hormones, such as: prolactin, growth hormone and insulin frequently also occur. The clinical consequences of the abovementioned endocrine abnormalities are among others: anemia, infertility and bone diseases.</p></abstract>

In patients with chronic kidney disease the alterations of the endocrine system may arise from several causes. The kidney is the site of degradation as well as synthesis of many different hormones. Moreover, a number of concomitant pathological conditions such as inflammation, metabolic acidosis and malnutrition may participate in the pathogenesis of endocrine abnormalities in this group of patients. The most pronounced endocrine abnormalities in patients with chronic kidney disease are the deficiencies of: calcitriol, testosterone, insulin-like growth factor and, erythropoietin (EPO). Additionally accumulation of several hormones, such as: prolactin, growth hormone and insulin frequently also occur. The clinical consequences of the abovementioned endocrine abnormalities are among others: anemia, infertility and bone diseases.

Endocrine Abnormalities in Patients with Chronic Kidney Disease

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Francuska Str. 20/24, 40-027 Katowice, Poland

PRILOZI

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Endocrine Abnormalities in Patients with Chronic Kidney Disease"}

In patients with chronic kidney disease the alterations of the endocrine system may arise from several causes. The kidney is the site of degradation as well as...

Endocrine Abnormalities in Patients with Chronic Kidney Disease

Published Online: Dec 30, 2015

Page range: 109 - 118

DOI: https://doi.org/10.1515/prilozi-2015-0059

Keywords
Chronic kidney disease, Endocrine abnormalities, Erythropoietin

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Endocrine Abnormalities in Patients with Chronic Kidney Disease

Published Online: Dec 30, 2015

Page range: 109 - 118

DOI: https://doi.org/10.1515/prilozi-2015-0059

KeywordsChronic kidney disease, Endocrine abnormalities, Erythropoietin

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Chronic kidney disease, Endocrine abnormalities, Erythropoietin