<abstract xmlns="http://www.w3.org/1999/xhtml">Recurrent aphthous stomatitis (RAS) is a quite frequent, painful, ulcerative disease that affects the lining of the oral cavity and has an unknown etiology. The aim of this article is to examine the impact of the medication proaftol on epithelization speed and severity of pain in patients with RAS. In this randomized, double-blind, placebo-controlled study respondents were divided into two groups where one group was treated with proaftol spray and the other with a placebo. Aphthae considered for treatment had a diameter of 5-6 mm. The participants were given instruction on the use of the spray, two sprayings on the place of the aphtae 3-4 times a day. We examined two parameters in the symptomatology of RAS-lesion size (mm) and pain intensity (noted on four subjective levels: 0-no pain, 1-discomfort, 2-moderate pain, 3-severe pain). These parameters were noted on the baseline, the third, the fifth and the eighth days of examination.Results: A significant faster reduction of the dimension of aphthous ulcers in patients treated with proaftol 3rd day p &lt; 0.001, 5th day p &lt; 0.0006, 8th day full epithelization in the control group. The magnitude of pain in the experimental compared with the control group on 3rd, 5th and 8th day was also significantly reduced: p &lt; 0.0001, p &lt; 0.007, p &lt; 0.007 respectively.Conclusion: The use of proaftol positively influences the rate of epithelization and reduction of subjective feeling of pain in patients with RAS. The action of propolis should be the goal of studies with a larger number of subjects.</abstract>

Recurrent aphthous stomatitis (RAS) is a quite frequent, painful, ulcerative disease that affects the lining of the oral cavity and has an unknown etiology. The aim of this article is to examine the impact of the medication proaftol on epithelization speed and severity of pain in patients with RAS. In this randomized, double-blind, placebo-controlled study respondents were divided into two groups where one group was treated with proaftol spray and the other with a placebo. Aphthae considered for treatment had a diameter of 5-6 mm. The participants were given instruction on the use of the spray, two sprayings on the place of the aphtae 3-4 times a day. We examined two parameters in the symptomatology of RAS-lesion size (mm) and pain intensity (noted on four subjective levels: 0-no pain, 1-discomfort, 2-moderate pain, 3-severe pain). These parameters were noted on the baseline, the third, the fifth and the eighth days of examination.Results: A significant faster reduction of the dimension of aphthous ulcers in patients treated with proaftol 3rd day p < 0.001, 5th day p < 0.0006, 8th day full epithelization in the control group. The magnitude of pain in the experimental compared with the control group on 3rd, 5th and 8th day was also significantly reduced: p < 0.0001, p < 0.007, p < 0.007 respectively.Conclusion: The use of proaftol positively influences the rate of epithelization and reduction of subjective feeling of pain in patients with RAS. The action of propolis should be the goal of studies with a larger number of subjects.

The Rapeutic Effect of Proaftol in Treatment of Recurrent Aphthous Stomatitis

Department of Oral Pathology and Periodontology

University Dental Clinical Centre - Skopje

PRILOZI

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Rapeutic Effect of Proaftol in Treatment of Recurrent Aphthous Stomatitis"}

Recurrent aphthous stomatitis (RAS) is a quite frequent, painful, ulcerative disease that affects the lining of the oral cavity and has an unknown etiology....

The Rapeutic Effect of Proaftol in Treatment of Recurrent Aphthous Stomatitis

Published Online: Mar 01, 2015

Page range: 195 - 202

DOI: https://doi.org/10.1515/prilozi-2015-0024

Keywords
Recurrent aphthous stomatitis, propolis, aphthous ulcers

© 2015 Aneta Atanasovska Stojanovska et. al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Rapeutic Effect of Proaftol in Treatment of Recurrent Aphthous Stomatitis

Published Online: Mar 01, 2015

Page range: 195 - 202

DOI: https://doi.org/10.1515/prilozi-2015-0024

KeywordsRecurrent aphthous stomatitis, propolis, aphthous ulcers

© 2015 Aneta Atanasovska Stojanovska et. al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Recurrent aphthous stomatitis, propolis, aphthous ulcers