<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Two derivatives of glutamine were synthesized and the most convenient physical conditions for obtaining reactions were established in factorial experiments with temperature and time of reactions considered as relevant variables. A quantum-mechanical characterization for the new compounds was performed by using HyperChem 8.0.6 Programs and their physical and chemical properties were theoretically estimated. The toxicity of two new compounds was experimentally determined.</p></abstract>

Two derivatives of glutamine were synthesized and the most convenient physical conditions for obtaining reactions were established in factorial experiments with temperature and time of reactions considered as relevant variables. A quantum-mechanical characterization for the new compounds was performed by using HyperChem 8.0.6 Programs and their physical and chemical properties were theoretically estimated. The toxicity of two new compounds was experimentally determined.

Two (Sulfone-Amidosulphonyl)-Amides Derived from N-(P-Amidobenzoyl)-L-Glutamine; Optimized Synthesis and Toxicity Study

“Grigore T. Popa” Medicine and Pharmacy University, Iași, Romania

“Alexandru Ioan Cuza” University, Faculty of Physics, Iași, Romania

“Alexandru Ioan Cuza” University, Faculty of Chemistry, Iași, Romania

International conference KNOWLEDGE-BASED ORGANIZATION

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Two derivatives of glutamine were synthesized and the most convenient physical conditions for obtaining reactions were established in factorial experiments...

Two (Sulfone-Amidosulphonyl)-Amides Derived from N-(P-Amidobenzoyl)-L-Glutamine; Optimized Synthesis and Toxicity Study

Published Online: Jul 27, 2016

Page range: 609 - 615

DOI: https://doi.org/10.1515/kbo-2016-0105

Keywords
N-[p-(R)-Benzoyl]-L-Glutamine derivatives, factorial experiment for optimization, QSAR parameters, toxicity test

© 2015 Corina Cheptea et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Two (Sulfone-Amidosulphonyl)-Amides Derived from N-(P-Amidobenzoyl)-L-Glutamine; Optimized Synthesis and Toxicity Study

Published Online: Jul 27, 2016

Page range: 609 - 615

DOI: https://doi.org/10.1515/kbo-2016-0105

KeywordsN-[p-(R)-Benzoyl]-L-Glutamine derivatives, factorial experiment for optimization, QSAR parameters, toxicity test

© 2015 Corina Cheptea et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
N-[p-(R)-Benzoyl]-L-Glutamine derivatives, factorial experiment for optimization, QSAR parameters, toxicity test