<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Introduction: Thyroid hormones affect protein turnover, and in the case of hypothyroidism a decrease in protein synthesis and reduced release of certain amino acids from skeletal muscles are observed. Changes in the amino acid system of skeletal muscles may be responsible for the occurrence of muscle disorders. Material and Methods: The study measured the content of selected amino acids in the gastrocnemius muscle of Wistar rats during experimental hypothyroidism induced by oral administration of methimazole at a concentration of 0.05% in drinking water for 90 d. The rats were divided into four groups: E1 (n = 6) - experimental males, E2 (n = 6) - experimental females, C1 (n = 6) - control males, and C2 (n = 6) control females. Results: A statistically significant reduction occurred in leucine, isoleucine, and 1-methylhistidine levels in males, and 1-methylhistidine in females, in comparison to the control groups. Conclusion: The hypothyroidism-induced changes in amino acid content may be responsible for the occurrence of skeletal muscle function disorders.</p></abstract>

Introduction: Thyroid hormones affect protein turnover, and in the case of hypothyroidism a decrease in protein synthesis and reduced release of certain amino acids from skeletal muscles are observed. Changes in the amino acid system of skeletal muscles may be responsible for the occurrence of muscle disorders. Material and Methods: The study measured the content of selected amino acids in the gastrocnemius muscle of Wistar rats during experimental hypothyroidism induced by oral administration of methimazole at a concentration of 0.05% in drinking water for 90 d. The rats were divided into four groups: E1 (n = 6) - experimental males, E2 (n = 6) - experimental females, C1 (n = 6) - control males, and C2 (n = 6) control females. Results: A statistically significant reduction occurred in leucine, isoleucine, and 1-methylhistidine levels in males, and 1-methylhistidine in females, in comparison to the control groups. Conclusion: The hypothyroidism-induced changes in amino acid content may be responsible for the occurrence of skeletal muscle function disorders.

Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats

Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin,

Chair and Department of Medical Chemistry, Medical University, 20-093 Lublin,

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences, 20-033 Lublin,

Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin,

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Introduction: Thyroid hormones affect protein turnover, and in the case of hypothyroidism a decrease in protein synthesis and reduced release of certain amino...

Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats

Published Online: Dec 17, 2016

Page range: 489 - 493

Received: Jun 22, 2016

Accepted: Nov 16, 2016

DOI: https://doi.org/10.1515/jvetres-2016-0072

Keywords
rats, hypothyroidism, amino acids, muscle

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats

Published Online: Dec 17, 2016

Page range: 489 - 493

Received: Jun 22, 2016

Accepted: Nov 16, 2016

DOI: https://doi.org/10.1515/jvetres-2016-0072

Keywordsrats, hypothyroidism, amino acids, muscle

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
rats, hypothyroidism, amino acids, muscle