1. bookVolume 2 (2017): Issue 2 (June 2017)
Journal Details
License
Format
Journal
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Copyright
© 2020 Sciendo
Journal Details
License
Format
Journal
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Copyright
© 2020 Sciendo

Stem cell-based therapy is a new therapeutic option that can be used in patients with cardiac diseases caused by myocardial injury. Cardiac magnetic resonance imaging (MRI) is a new noninvasive imaging method with an increasingly widespread indication. The aim of this review was to evaluate the role of cardiac MRI in patients with myocardial infarction undergoing stem cell therapy. We studied the role of MRI in the assessment of myocardial viability, stem cell tracking, assessment of cell survival rate, and monitoring of the long-term effects of stem cell therapy. Based on the current knowledge in this field, this noninvasive, in vivo cardiac imaging technique has a large indication in this group of patients and plays an important role in all stages of stem cell therapy, from the indication to the long-term follow-up of patients.

Keywords

1. European Cardiovascular Disease Statistics 2017. Avaible at: http://www.ehnheart.org/cvd-statistics.htmlSearch in Google Scholar

2. Konstam MA, Kramer DG, Patel AR, et al. Left ventricular remodeling in heart failure current concepts in clinical significance and assessment. J Am Coll Cardiol Img. 2011;4:98-108.Search in Google Scholar

3. Abbate A, Biondi-Zoccai GG, Appleton DL, et al. Survival and cardiac remodeling benefits in patients undergoing late percutaneous coronary intervention of the infarct-related artery: evidence from a meta-analysis of randomized controlled clinical trials. J Am Coll Cardiol. 2008;21:956-964.Search in Google Scholar

4. David G, David AB. MRI determination of myocardial viability. Appl Radiol. 2006;35.Search in Google Scholar

5. Frangioni JV, Hajjar RJ. In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation. 2004;110:3378-3383.Search in Google Scholar

6. Chen IY, Wu JC. Cardiovascular molecular imaging: focus on clinical translation. Circulation. 2011;123:425-443.Search in Google Scholar

7. Comella K, Griffeth J. Stem Cell Research in the Cardiac Field: Where Are We Now? World Stem Cell Report. 2009.Search in Google Scholar

8. Krishna KA, Krishna KS, Berrocal R, Rao KS, Sambasiva Rao KRS. Myocardial infarction and stem cells. Myocardial infarction and stem cells. J Pharm Bioallied Sci. 2011;3:182-188.Search in Google Scholar

9. Perin EC, López J. Methods of stem cell delivery in cardiac diseases. Nat Clin Pract Cardiovasc Med. 2006:Suppl1:110-113.Search in Google Scholar

10. Bodo-Eckehard S, Gustav S. 10 Years of Intracoronary and Intramyocardial Bone Marrow Stem Cell Therapy of the Heart. J Am Coll Cardiol. 2011;58:1095-1104.Search in Google Scholar

11. Whitney F, Rony A. Therapeutic use of stem cells for cardiovascular disease. Clin Transl Med. 2016;5:34.Search in Google Scholar

12. Donndorf P, Strauer BE. Stem cell therapy for the treatment of acute myocardial infarction and chronic ischemic heart disease. Curr Pharm Biotechnol. 2013;14:12-19.Search in Google Scholar

13. Lau JF, Anderson SA, Adler E, Frank JA. Imaging approaches for the study of cell-based cardiac therapies. Nat Rev Cardiol. 2009;7:97-105.Search in Google Scholar

14. Mahrholdt H, Wagner A, Holly TA, et al. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation. 2002;106: 2322-2327.Search in Google Scholar

15. Al Saadi N, Nagel E, Gross M, et al. Noninvasive detection of myocardial ischemia from perfusion reserve based on cardiovascular magnetic resonance. Circulation. 2000;101:1379-1383.Search in Google Scholar

16. Baer FM, Theissen P, Schneider CA, et al. Dobutamine magnetic resonance imaging predicts contractile recovery of chronically dysfunctional myocardium after successful revascularization. J Am Coll Cardiol. 1998;31:1040-1048.Search in Google Scholar

17. Hassan AA, Anja Z. Delayed Enhancement and T2-Weighted Cardiovascular Magnetic Resonance Imaging Differentiate Acute From Chronic Myocardial Infarction. Circulation. 2003;107:2290-2293.Search in Google Scholar

18. Wagner A, Mahrholdt H, Holly TA, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003;361:374-379.Search in Google Scholar

19. Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J. 2007;28:2525-2538.Search in Google Scholar

20. Dash R, Kim PJ, Matsuura Y, et al. Manganese-enhanced MRI enables in vivo confirmation of peri-infarct restoration following stem cell therapy in porcine ischemia-reperfusion model. J Am Heart Assoc. 2015;4:e002044.Search in Google Scholar

21. Choi KM, Kim RJ, Gubernikoff G, et al. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation. 2001;104:1101-1107.Search in Google Scholar

22. Gerber BL, Garot J, Bluemke DA, Wu KC, Lima JAC. Accuracy of contrast-enhanced magnetic resonance imaging in predicting improvement of regional myocardial function in patients after acute myocardial infarction. Circulation. 2002;106:1083-1089.Search in Google Scholar

23. Kim RJ, Fieno DS, Parrish TB, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation.1999;100:1992-2002.Search in Google Scholar

24. van Assche LMR, Kim HW, Kim RJ. Cardiac Mr For The Assessment Of Myocardial Viability. Methodist Debakey Cardiovascular Journal. 2013;9:163-168.Search in Google Scholar

25. Romero J, Xue X, Gonzalez W, et al. CMR imaging assessing viability in patients with chronic ventricular dysfunction due to coronary artery disease: a meta-analysis of prospective trials. JACC Cardiovasc Imaging. 2012;5:494-508.Search in Google Scholar

26. Cwajg JM, Cwajg E, Nagueh SF, et al. End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation: relation to rest-redistribution T1-201 tomography and dobutamine stress echocardiography. J Am Coll Cardiol. 2000;35:1152-1161.Search in Google Scholar

27. Shah DJ, Kim HW, Elliott M, et al. Contrast MRI predicts reverse remodeling and contractile improvement in akinetic thinned myocardium. Circulation. 2003;108:697.Search in Google Scholar

28. Wu YW, Tadamura E, Yamamuro M, et al. Comparison of contrast-enhanced MRI with (18) F-FDG PET/201Tl SPECT in dysfunctional myocardium: relation to early functional outcome after surgical revascularization in chronic ischemic heart disease. J Nucl Med. 2007;48:1096-1103.Search in Google Scholar

29. Grover S, Srinivasan G, Selvanayagam JB. Myocardial viability imaging: does it still have a role in patient selection prior to coronary revascularisation? Heart Lung Circ. 2012;21:468-479.Search in Google Scholar

30. Xi L, Rui X, Zhang B, Gao F. MRI tracking stem cells transplantation for coronary heart disease. Pak J Med Sci. 2014;30:899-903.Search in Google Scholar

31. Sterenczak KA, Meier M, Glage S, et al. Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer. BMC Cancer. 2012;12:284.Search in Google Scholar

32. Guenoun J, Koning GA, Doeswijk G, et al. Cationic Gd-DTPA liposomes for highly efficient labeling of mesenchymal stem cells and cell tracking with MRI. Cell Transplant. 2012;21:191-205.Search in Google Scholar

33. Mamani JB, Pavon LF, Miyaki LA, et al. Intracellular labeling and quantification process by magnetic resonance imaging using iron oxide magnetic nanoparticles in rat C6 glioma cell line. Einstein. 2012;10:216-221.Search in Google Scholar

34. Vuong QL, Van Doorslaer S, Bridot JL, et al. Paramagnetic nanoparticles as potential MRI contrast agents: characterization, NMR relaxation, simulations and theory. MAGMA. 2012; 25:467-478.Search in Google Scholar

35. Bowen CV, Zhang X, Saab G, Gareau PJ, Rutt BK. Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells. Magn Reson Med. 2002;48:52-61.Search in Google Scholar

36. Moriel V. Cardiac Cell Tracking with MRI Reporter Genes: Welcoming a New Field. Curr Cardiovasc Imaging Rep. 2014;7:9250.Search in Google Scholar

37. Vandsburger MH, Radoul M, et al. MRI reporter genes: applications for imaging of cell survival, proliferation, migration and differentiation. NMR Biomed. 2013;26:872-84.Search in Google Scholar

38. Lee SW, Lee SH, et al. Magnetic resonance reporter gene imaging. Theranostics.2012;2:403-12.Search in Google Scholar

39. Naumova AV, Reinecke H, et al. Ferritin overexpression for noninvasive magnetic resonance imaging-based tracking of stem cells transplanted into the heart. Mol Imaging. 2010 Aug;9:201-210.Search in Google Scholar

40. Naumova AV, Yarnykh VL, Cohen B, Neeman M. Quantification of MRI signal of transgenic grafts overexpressing ferritin in murine myocardial infarcts. NMR Biomedicine. 2012;25:1187-1195.Search in Google Scholar

41. Moriel Vandsburger. Cardiac Cell Tracking with MRI Reporter Genes: Welcoming a New Field. Curr Cardiovasc Imaging Rep. 2014;7:9250.Search in Google Scholar

42. Patricia KN, Feng L, Wang Y, Wu JC. Imaging: Guiding the Clinical Translation of Cardiac Stem Cell Therapy. Circ Res. 2011;109:962-979.Search in Google Scholar

43. David E. Sosnovik. Seeing What We Build—The Need for New Imaging Techniques in Myocardial Regeneration. J Am Heart Assoc. 2015;4:e002306.Search in Google Scholar

44. Cao F, Lin S, Xie X, et al. In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation. 2006;113:1005-1014.Search in Google Scholar

45. Terrovitis JV, Smith RR, Marbán E. Assessment and Optimization of Cell Engraftment after Transplantation into the Heart. Circ Res. 2010;106:479-494.Search in Google Scholar

46. Amsalem Y, Mardor Y, Feinberg MS, et al. Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium. Circulation. 2007;116:38-45.Search in Google Scholar

47. Terrovitis J, Stuber M, et al. Iron-labeled stem cells seen by magnetic resonance imaging: dead or alive? Circulation. 2006;114:264.Search in Google Scholar

48. Partlow KC, Chen J, Brant J, Wickline SA. 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J. 2007;21:1647-1654.Search in Google Scholar

49. Berry MF, Engler AJ, Woo YJ, et al. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol. 2006;290:2196-2203.Search in Google Scholar

50. Nesteruk J, Voronina N, Kundt G, et al. Stem cell registry programme for patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting: what benefits does it derive? ESC Heart Fail. 2017;4:105-111.Search in Google Scholar

51. Traverse JH, Henry TD, Pepine CJ, Willerson JT, Ellis SG. One-Year Follow-up of Intracoronary Stem Cell Delivery on Left-Ventricular Function Following ST-Elevation Myocardial Infarction. JAMA. 2014;311:301-302.Search in Google Scholar

52. Malliaras K, Makkar RR, Smith RR, et al. Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction: Evidence of Therapeutic Regeneration in the Final 1-Year Results of the CADUCEUS Trial. J Am Coll Cardiol. 2014;63(2):110-122.Search in Google Scholar

53. Lipinski MJ, Biondi-Zoccai GG, Abbate A, Vetrovec GW. Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol. 2007;50:1761-1767.Search in Google Scholar

54. Martin-Rendon E, Brunskill SJ, Hyde CJ, Stanworth SJ, Mathur A, Watt SM. Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. Eur Heart J. 2008;29:1807-1818.Search in Google Scholar

55. Delewi R, Hirsch A, Tijssen JG, et al. Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST-segment elevation myocardial infarction: a collaborative meta-analysis. Eur Heart J. 2014;35:989-998.Search in Google Scholar

56. Jeevanantham V, Butler M, Saad A, et al. Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation. 2012;126:551-568.Search in Google Scholar

Plan your remote conference with Sciendo