<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Myocardial ischemia caused by coronary atherosclerosis is the main cause of cardiovascular mortality, which is the first cause of death in developed countries. Inducible myocardial ischemia is a negative prognostic factor for coronary artery disease patients, and it represents a major risk stratification marker for predicting mortality. The evolution of these patients depends largely on the extension of the ischemic myocardial mass and the severity of the inducible ischemia. Most patients do not show angiographically significant coronary stenosis. Therefore, such patients do not undergo coronary revascularization therapies, even though they present functional stenoses that trigger myocardial ischemia under stress conditions, which subsequently lead to a high risk for major adverse cardiovascular events. We performed a review that aims to pinpoint invasive techniques used for evaluating the functional impact of a coronary lesion that is considered non-significant upon angiographic examination, but which triggers episodes of myocardial ischemia under stress conditions, and to describe the functional markers that show the highest specificity for predicting ischemic risk, in order to recommend invasive coronary revascularization.</p></abstract>

Myocardial ischemia caused by coronary atherosclerosis is the main cause of cardiovascular mortality, which is the first cause of death in developed countries. Inducible myocardial ischemia is a negative prognostic factor for coronary artery disease patients, and it represents a major risk stratification marker for predicting mortality. The evolution of these patients depends largely on the extension of the ischemic myocardial mass and the severity of the inducible ischemia. Most patients do not show angiographically significant coronary stenosis. Therefore, such patients do not undergo coronary revascularization therapies, even though they present functional stenoses that trigger myocardial ischemia under stress conditions, which subsequently lead to a high risk for major adverse cardiovascular events. We performed a review that aims to pinpoint invasive techniques used for evaluating the functional impact of a coronary lesion that is considered non-significant upon angiographic examination, but which triggers episodes of myocardial ischemia under stress conditions, and to describe the functional markers that show the highest specificity for predicting ischemic risk, in order to recommend invasive coronary revascularization.

Invasive FFR — Current Applications and New Developments

Center of Advanced Research in Multimodality Cardiac Imaging, Cardio Med Medical Center, Tîrgu Mureș,

University of Medicine and Pharmacy, Tîrgu Mureș,

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Invasive FFR \u2014 Current Applications and New Developments"}

Myocardial ischemia caused by coronary atherosclerosis is the main cause of cardiovascular mortality, which is the first cause of death in developed countries....

Invasive FFR — Current Applications and New Developments

Published Online: Dec 29, 2016

Page range: 231 - 236

Received: Oct 04, 2016

Accepted: Nov 02, 2016

DOI: https://doi.org/10.1515/jim-2016-0073

Keywords
invasive fractional flow reserve, inducible myocardial ischemia, functional significance of coronary stenosis

© 2016 Monica Chiţu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Invasive FFR — Current Applications and New Developments

Published Online: Dec 29, 2016

Page range: 231 - 236

Received: Oct 04, 2016

Accepted: Nov 02, 2016

DOI: https://doi.org/10.1515/jim-2016-0073

Keywordsinvasive fractional flow reserve, inducible myocardial ischemia, functional significance of coronary stenosis

© 2016 Monica Chiţu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
invasive fractional flow reserve, inducible myocardial ischemia, functional significance of coronary stenosis