<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction:</bold> Pulmonary arterial hypertension (PAH) is a complex disease with poor prognosis. Serum uric acid has been proposed as a potentially non-invasive and objective parameter for prognosis and response to therapy.<bold>Objectives:</bold> To investigate the potent relationship between serum uric acid levels and functional and echocardiographic parameters in children with PAH.<bold>Methods:</bold> Serum uric acid levels were measured in 34 children with PAH and were correlated with the functional class, 6-minute walk test, and echocardiographic parameters at baseline and at 12 months follow-up.<bold>Results:</bold> In pediatric PAH patients serum uric acid levels were higher compared with the control subjects (p = 0.001). In the high uric acid group serum uric acid levels were correlated with 6-minute walk test (p = 0.008), and with several echocardiographic parameters, such as pulmonary vascular resistance (p = 0.04), fractional area change (p = 0.05), left ventricle eccentricity index (p = 0.04), right atrial area (p = 0.03), right ventricle myocardial index (p = 0.01), and pericardial effusion (p = 0.001), markers of right ventricular overload and dysfunction.<bold>Conclusions:</bold> Serum uric acid levels are easy to collect and measure, and correlate with both functional and echocardiographic parameters that reflect right ventricular dysfunction.</abstract>

Introduction: Pulmonary arterial hypertension (PAH) is a complex disease with poor prognosis. Serum uric acid has been proposed as a potentially non-invasive and objective parameter for prognosis and response to therapy.Objectives: To investigate the potent relationship between serum uric acid levels and functional and echocardiographic parameters in children with PAH.Methods: Serum uric acid levels were measured in 34 children with PAH and were correlated with the functional class, 6-minute walk test, and echocardiographic parameters at baseline and at 12 months follow-up.Results: In pediatric PAH patients serum uric acid levels were higher compared with the control subjects (p = 0.001). In the high uric acid group serum uric acid levels were correlated with 6-minute walk test (p = 0.008), and with several echocardiographic parameters, such as pulmonary vascular resistance (p = 0.04), fractional area change (p = 0.05), left ventricle eccentricity index (p = 0.04), right atrial area (p = 0.03), right ventricle myocardial index (p = 0.01), and pericardial effusion (p = 0.001), markers of right ventricular overload and dysfunction.Conclusions: Serum uric acid levels are easy to collect and measure, and correlate with both functional and echocardiographic parameters that reflect right ventricular dysfunction.

Significance of Serum Uric Acid in Children with Pulmonary Arterial Hypertension

Department M3, Clinic of Cardiology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Significance of Serum Uric Acid in Children with Pulmonary Arterial Hypertension"}

Introduction: Pulmonary arterial hypertension (PAH) is a complex disease with poor prognosis. Serum uric acid has been proposed as a potentially non-invasive...

Significance of Serum Uric Acid in Children with Pulmonary Arterial Hypertension

Published Online: Jul 06, 2016

Page range: 46 - 50

Received: Mar 31, 2016

Accepted: May 14, 2016

DOI: https://doi.org/10.1515/jim-2016-0010

Keywords
uric acid, pulmonary arterial hypertension, children

© 2016 Carmen Corina Şuteu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Significance of Serum Uric Acid in Children with Pulmonary Arterial Hypertension

Published Online: Jul 06, 2016

Page range: 46 - 50

Received: Mar 31, 2016

Accepted: May 14, 2016

DOI: https://doi.org/10.1515/jim-2016-0010

Keywordsuric acid, pulmonary arterial hypertension, children

© 2016 Carmen Corina Şuteu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
uric acid, pulmonary arterial hypertension, children