<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Since 1994, alcohol septal ablation (ASA) has been used as a minimally invasive treatment of patients with hypertrophic obstructive cardiomyopathy, resistant to conservative medical therapy. This catheter-based intervention consists of injecting absolute alcohol in a septal perforator to induce infarction of the hypertrophied septum and thus diminish the left ventricle outflow tract obstruction. This reduction of the gradient is associated with reduction of symptoms and left ventricle remodeling. The procedure was improved after the introduction of myocardial contrast echocardiography for visualization of the area at risk of infarction and reduction of the alcohol amount. Major complications of ASA are rare but centers with experience have reported conduction disorders - about 10% of patients needed permanent pacing because of complete AV block. Large randomized prospective studies have not yet compared alcohol septal ablation to the gold standard for treatment of hypertrophic obstructive cardiomyopathy - surgical myomectomy.</p></abstract>

Since 1994, alcohol septal ablation (ASA) has been used as a minimally invasive treatment of patients with hypertrophic obstructive cardiomyopathy, resistant to conservative medical therapy. This catheter-based intervention consists of injecting absolute alcohol in a septal perforator to induce infarction of the hypertrophied septum and thus diminish the left ventricle outflow tract obstruction. This reduction of the gradient is associated with reduction of symptoms and left ventricle remodeling. The procedure was improved after the introduction of myocardial contrast echocardiography for visualization of the area at risk of infarction and reduction of the alcohol amount. Major complications of ASA are rare but centers with experience have reported conduction disorders - about 10% of patients needed permanent pacing because of complete AV block. Large randomized prospective studies have not yet compared alcohol septal ablation to the gold standard for treatment of hypertrophic obstructive cardiomyopathy - surgical myomectomy.

Alcohol Septal Ablation

Specialized Hospital for Active Treatment in Cardiology, Pleven

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Alcohol Septal Ablation"}

Since 1994, alcohol septal ablation (ASA) has been used as a minimally invasive treatment of patients with hypertrophic obstructive cardiomyopathy, resistant...

Alcohol Septal Ablation

Published Online: Dec 22, 2015

Page range: 104 - 111

Received: Apr 04, 2015

Accepted: Dec 01, 2015

DOI: https://doi.org/10.1515/jbcr-2015-0159

Keywords
hypertrophic cardiomyopathy, left ventricular outflow obstruction, alcohol septal ablation

© 2015 Desislava P. Petrova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Alcohol Septal Ablation

Published Online: Dec 22, 2015

Page range: 104 - 111

Received: Apr 04, 2015

Accepted: Dec 01, 2015

DOI: https://doi.org/10.1515/jbcr-2015-0159

Keywordshypertrophic cardiomyopathy, left ventricular outflow obstruction, alcohol septal ablation

© 2015 Desislava P. Petrova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
hypertrophic cardiomyopathy, left ventricular outflow obstruction, alcohol septal ablation