<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Drug induced nephrotoxicity is one of the most common causes of renal failure. Gentamicin belongs to aminoglycosides, which elicit nephrotoxic potential. Natural antioxidants from plants demonstrate a number of biotherapeutic activities. Coriander is an important medicinal plant known for its hepatoprotective, diuretic, carminative, digestive and antihelminthic potential. This study was designed to investigate whether the extract of <italic>Coriandrum sativum</italic> ameliorates the nephrotoxicity induced by gentamicin in rats. Dried coriander powder was coarsely grinded and subjected to defatting by petroleum ether and further with ethyl acetate. The extract was filtered and subjected to phytochemical and phytoanalytical studies.</p><p>Acute toxicity in Wistar rats was determined by the OECD Guideline (423). Animals were divided into four groups. The first group served as positive control, while the second group was toxic control (gentamicin treated). The third and fourth group were treated with the extract (200 and 400 mg/kg gentamicin). After 8 days, the animals were sacrificed and biochemical and histopathological studies were carried out. Phytochemical screening of the extract demonstrated <italic>Coriandrum sativum</italic> to be rich in flavonoids, polyphenolics and alkaloids. Results of acute toxicity suggested the use of 200 mg/kg and 400 mg/kg for <italic>Coriandrum sativum</italic> in the study. <italic>Coriandrum sativum</italic> extract at the dose of 400 mg/kg significantly (<italic>p</italic>&lt;0.01) decreased creatinine levels in the animals, along with a decrease in serum urea and blood urea nitrogen. Treatment with <italic>Coriandrum sativum</italic> extract ameliorated renal histological lesions. It is concluded that <italic>Coriandrum sativum</italic> is a potential source of nephroprotective phytochemical activity, with flavonoids and polyphenols as the major components.</p></abstract>

Drug induced nephrotoxicity is one of the most common causes of renal failure. Gentamicin belongs to aminoglycosides, which elicit nephrotoxic potential. Natural antioxidants from plants demonstrate a number of biotherapeutic activities. Coriander is an important medicinal plant known for its hepatoprotective, diuretic, carminative, digestive and antihelminthic potential. This study was designed to investigate whether the extract of Coriandrum sativum ameliorates the nephrotoxicity induced by gentamicin in rats. Dried coriander powder was coarsely grinded and subjected to defatting by petroleum ether and further with ethyl acetate. The extract was filtered and subjected to phytochemical and phytoanalytical studies.Acute toxicity in Wistar rats was determined by the OECD Guideline (423). Animals were divided into four groups. The first group served as positive control, while the second group was toxic control (gentamicin treated). The third and fourth group were treated with the extract (200 and 400 mg/kg gentamicin). After 8 days, the animals were sacrificed and biochemical and histopathological studies were carried out. Phytochemical screening of the extract demonstrated Coriandrum sativum to be rich in flavonoids, polyphenolics and alkaloids. Results of acute toxicity suggested the use of 200 mg/kg and 400 mg/kg for Coriandrum sativum in the study. Coriandrum sativum extract at the dose of 400 mg/kg significantly (p<0.01) decreased creatinine levels in the animals, along with a decrease in serum urea and blood urea nitrogen. Treatment with Coriandrum sativum extract ameliorated renal histological lesions. It is concluded that Coriandrum sativum is a potential source of nephroprotective phytochemical activity, with flavonoids and polyphenols as the major components.

Chemopreventive role of <italic>Coriandrum sativum</italic> against gentamicin-induced renal histopathological damage in rats

Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, M.P., India

Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, M.P., India.

Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Chemopreventive role of  against gentamicin-induced renal histopathological damage in rats

Drug induced nephrotoxicity is one of the most common causes of renal failure. Gentamicin belongs to aminoglycosides, which elicit nephrotoxic potential....

Chemopreventive role of Coriandrum sativum against gentamicin-induced renal histopathological damage in rats

Published Online: Mar 07, 2016

Page range: 99 - 102

Received: Mar 02, 2014

Accepted: Feb 17, 2015

DOI: https://doi.org/10.1515/intox-2015-0015

Keywords
nephroprotection, blood urea nitrogen, creatinine, serum urea

© 2015 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Chemopreventive role of Coriandrum sativum against gentamicin-induced renal histopathological damage in rats

Published Online: Mar 07, 2016

Page range: 99 - 102

Received: Mar 02, 2014

Accepted: Feb 17, 2015

DOI: https://doi.org/10.1515/intox-2015-0015

Keywordsnephroprotection, blood urea nitrogen, creatinine, serum urea

© 2015 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
nephroprotection, blood urea nitrogen, creatinine, serum urea