1. bookVolume 50 (2016): Issue 1 (January 2016)
Journal Details
License
Format
Journal
eISSN
1336-0329
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
access type Open Access

Handedness and gender influence blood pressure in young healthy men and women: A pilot study

Published Online: 22 Feb 2016
Volume & Issue: Volume 50 (2016) - Issue 1 (January 2016)
Page range: 10 - 15
Journal Details
License
Format
Journal
eISSN
1336-0329
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Abstract

Objective. The type and level of sex steroids influence blood pressure (BP). It has been suggested that functional brain asymmetries may be influenced by sex hormones. In addition, there are inter-arm differences in BP not yet related with handedness. In this study, we hypothesize a possible association between sex hormones, handedness, and inter-arm differences in blood pressure.

Methods. To analyze this hypothesis, we measured BP in the left and right arm of the left and right handed adult young men and women in menstrual and ovulatory phase and calculated their mean arterial pressure (MAP).

Results. Significant differences depending on sex, arm, handedness or phase of the cycle were observed. MAP was mostly higher in men than in women. Remarkably, in women, the highest levels were observed in the left handed in menstrual phase. Interestingly, the level of handedness correlated negatively with MAP measured in the left arm of right-handed women in the ovulatory phase but positively with the MAP measured in the right arm of right-handed women in the menstrual phase.

Conclusions. These results may reflect an asymmetrical modulatory influence of sex hormones in BP control.

Keywords

Banegas I, Prieto I, Segarra AB, Duran R, Vives F, Alba F, Luna JD, de Gasparo M, Wangesteen R, Ruiz-Bailen M, Ramirez-Sanchez M. Blood pressure increased dramatically in hypertensive rats after left hemisphere lesions with 6-hydroxydopamine. Neurosci Lett 500, 148–150, 2011.10.1016/j.neulet.2011.06.025Search in Google Scholar

Bayer U, Hausmann M. Menstrual cycle-related changes of functional cerebral asymmetries in fine motor coordination. Brain Cogn 79, 34–38, 2012.10.1016/j.bandc.2012.02.003Search in Google Scholar

Bryden PJ, Bruyn J, Fletcher P. Handedness and health: an examination of the association between different handedness classifications and health disorders. Laterality 10, 429–440, 2005.10.1080/13576500442000193Search in Google Scholar

Clark CE. Difference in blood pressure measurements between arms: methodological and clinical implications. Curr Pharm Des 21, 737–743, 2015.10.2174/1381612820666141024124349Search in Google Scholar

Dubey RK, Oparil S, Imthurn B, Jackson EK. Sex hormones and hypertension. Cardiovasc Res 53, 688–708, 2002.10.1016/S0008-6363(01)00527-2Search in Google Scholar

Dunne FP, Barry DG, Ferriss JB, Grealy G, Murphy D. Changes in blood pressure during the normal menstrual cycle. ClinSci (Lond) 81, 515–518, 1991.10.1042/cs08105151657498Search in Google Scholar

Dunson DB, Baird DD, Wilcox AJ, Weinberg CR. Day-specific probabilities of clinical pregnancy based on two studies with imperfect measures of ovulation. Hum Reprod 14, 1835–1839, 1999.10.1093/humrep/14.7.183510402400Search in Google Scholar

Duskova M, Simunkova K, Hill M, Starka L. 7-hydroxylated derivatives of dehydroepiandrosterone as possibly related to menstrual mood change in healthy women. Endocr Regul 45, 131–137, 2011.10.4149/endo_2011_03_13121793625Search in Google Scholar

Grossman A, Prokupetz A, Gordon B, Morag-Koren N, Grossman E. Inter-arm blood pressure differences in young, healthy patients. J ClinHypertens (Greenwich) 15, 575–578, 2013.10.1111/jch.12125803393123889720Search in Google Scholar

Gur RC, Gur RE, Obrist WD, Hungerbuhler JP, Younkin D, Rosen AD, Skolnick BE, Reivich M. Sex and handedness differences in cerebral blood flow during rest and cognitive activity. Science 217, 659–661, 1982.10.1126/science.70895877089587Search in Google Scholar

Gur RE, Gur RC. Gender differences in regional cerebral blood flow. Schizophr Bull 16, 247–254, 1990.10.1093/schbul/16.2.247Search in Google Scholar

Klabunde RE. Cardiovascular physiology concepts—mean arterial pressure. Lippincott Williams & Wilkins, 2011. Available at: http://www.cvphysiology.com/BloodPressure/BP006.htm.Search in Google Scholar

Krejza J, Rudzinski W, Arkuszewski M, Onuoha O, Melhem ER. Cerebrovascular reactivity across the menstrual cycle in young healthy women. Neuroradiol J 26, 413–419, 2013.10.1177/197140091302600406Search in Google Scholar

McManus C. Right Hand, Left Hand. The Origins of Asymmetry in Brains, Bodies, Atoms and Cultures. Weidenfeld & Nicolson, London, 2002.Search in Google Scholar

Minson CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101, 862–868, 2000.10.1161/01.CIR.101.8.862Search in Google Scholar

Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97–113, 1971.10.1016/0028-3932(71)90067-4Search in Google Scholar

Sandberg K, Ji H. Sex differences in primary hypertension. Biol Sex Differ 3, 7, 2012.10.1186/2042-6410-3-7333182922417477Search in Google Scholar

Segarra AB, Prieto I, Banegas I, Villarejo AB, Wangensteen R, de Gasparo M, Vives F, Ramirez-Sanchez M. The brain-heart connection: frontal cortex and left ventricle angiotensinase activities in control and captopriltreated hypertensive rats-a bilateral study. Int J Hypertens 2013:156179, 2013.Search in Google Scholar

Verberk WJ, Kessels AG, Thien T. Blood pressure measurement method and inter-arm differences: a meta-analysis. Am J Hypertens 24, 1201–1208, 2011.10.1038/ajh.2011.12521776035Search in Google Scholar

Weis S, Hausmann M. Sex hormones: modulators of interhemispheric inhibition in the human brain. Neuroscientist 16, 132–138, 2010.10.1177/107385840934148119729358Search in Google Scholar

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