<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The recent study assessed TGF-β and IL-10 as immunosuppressive cytokines of the cell
mediated immunity (CMI) against Brucella in the serum of some brucellosis patients.
Serum from 15 patients and 15 healthy individuals were obtained, and then cytokine
concentrations above were investigated. Concentrations of TGF-β induced in the serum of
acute patients (89.73 ± 15.55 ng/ml) were higher than healthy group (58.86 ± 17.89 ng/ml,
P &lt; 0.0001). While, no significant differences were found in the concentration of IL-10
between two groups. Based upon the findings of our study, the contribution of these
cytokines to the pathobiology of infection had been shown. Therefore, assessment of
immunosuppressive cytokines as TGF-β and IL-10 levels may be a potential diagnostic
strategy for patients with brucellosis.</p></abstract>

The recent study assessed TGF-β and IL-10 as immunosuppressive cytokines of the cell
mediated immunity (CMI) against Brucella in the serum of some brucellosis patients.
Serum from 15 patients and 15 healthy individuals were obtained, and then cytokine
concentrations above were investigated. Concentrations of TGF-β induced in the serum of
acute patients (89.73 ± 15.55 ng/ml) were higher than healthy group (58.86 ± 17.89 ng/ml,
P < 0.0001). While, no significant differences were found in the concentration of IL-10
between two groups. Based upon the findings of our study, the contribution of these
cytokines to the pathobiology of infection had been shown. Therefore, assessment of
immunosuppressive cytokines as TGF-β and IL-10 levels may be a potential diagnostic
strategy for patients with brucellosis.

Assessment of TGF-β and IL10 levels in human brucellosis

Department of Immunology, School of Medicine

Infectious Diseases and Tropical Medicine Research Center, Health Research Institute

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Assessment of TGF-β and IL10 levels in human brucellosis"}

The recent study assessed TGF-β and IL-10 as immunosuppressive cytokines of the cell
mediated immunity (CMI) against Brucella in the serum of some brucellosis...

Assessment of TGF-β and IL10 levels in human brucellosis

Published Online: Apr 11, 2018

Page range: 22 - 24

Received: Nov 05, 2017

Accepted: Dec 18, 2017

DOI: https://doi.org/10.1515/cipms-2018-0005

Keywords
brucellosis, ELISA, TGF-β, IL-10

© 2017 Mousa Mohammadnia-Afrouzi et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Assessment of TGF-β and IL10 levels in human brucellosis

Published Online: Apr 11, 2018

Page range: 22 - 24

Received: Nov 05, 2017

Accepted: Dec 18, 2017

DOI: https://doi.org/10.1515/cipms-2018-0005

Keywordsbrucellosis, ELISA, TGF-β, IL-10

© 2017 Mousa Mohammadnia-Afrouzi et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
brucellosis, ELISA, TGF-β, IL-10