Association of the MMP7 –181A>G promoter polymorphism with early onset of chronic obstructive pulmonary disease
, , , , , , and | Dec 29, 2017
About this article
Article Category: Original Article
Published Online: Dec 29, 2017
Page range: 59 - 65
DOI: https://doi.org/10.1515/bjmg-2017-0023
Keywords
© 2017 Tacheva T, Dimov D, Anastasov A, Zhelyazkova Y, Kurzawski M, Gulubova M, Drozdzik M, Vlaykova T, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
Genotype and allele and genotype frequencies of the MMP7 –181A>G gene polymorphism in the patients with chronic obstructive pulmonary disease and controls younger than 60 years.
| Patients | Controls | OR (95% CI) | OR (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| Frequency | Frequency | |||||||
| AA | 11 | 0.145 | 35 | 0.330 | 1.0 (referent) | 1.0 (referent) | ||
| AG | 43 | 0.566 | 50 | 0.471 | 2.736 (1.252-5.962) | The bold | 4.742 (1.426-15.768) | The bold |
| GG | 22 | 0.289 | 21 | 0.198 | 3.333 (1.363-8.148) | The bold | 3.194 (0.862-11.830) | 0.082 |
| AG+GG | 65 | 0.855 | 71 | 0.670 | 2.913 (1.380-6.133) | The bold | 4.122 (1.318-12.890) | The bold |
| –181 A | 65 | 0.428 | 120 | 0.566 | 1.0 (referent) | – | – | – |
| –181 G | 87 | 0.572 | 92 | 0.434 | 1.746 (1.147-2.657) | The bold | – | – |
Demographic and clinical data of patients with chronic obstructive pulmonary disease and controls.
| Characteristics | Patients with COPD (%) | Controls (%) | |
|---|---|---|---|
| Number | 191 | 215 | |
| males | 146 (76.4) | 109 (50.7) | <0.001 Determined by the |
| females | 45 (23.6) | 106 (49.3) | |
| Age (years) at inclusion in the study median (range) | 67 (36-88) | 59 (18-80) | <0.001 Determined by the Mann-Whitney U test. |
| Age (years) at diagnosis of the disease median (range) | 64 (30-86) | – | |
| Smoking status | |||
| non-smokers | 54 (29.0) | 97 (59.0) | <0 001 Determined by the |
| ex-smokers | 89 (48.0) | 25 (15.0) | |
| current smokers | 43 (23.0) | 42 (26.0) | |
| FEV1 %pr (mean ± SD) (range) | 50.60 ± 14.10 (15-79) | 93.40 ± 11.90 (82-114) | <0.001 Determined by the Mann-Whitney U test. |
| FEV1/FVC % (mean ± SD (range | 61.1 ± 8.6 (27.1-70.0) | 80.4 ± 7.2 (76.3-93.0) | <0.001 Determined by the Mann-Whitney U test. |
| COPD staging (GOLD 2009) | |||
| stage II (moderate) | 102 (55.0%) | – | |
| stage III (severe) | 73 (39.0) | – | |
| stage IV (very severe) | 11 (67.0) | – | |
Genotype and allele frequencies of the MMP7 –181A>G gene polymorphism in patients with chronic obstructive pulmonary disease and controls.
| Patients | Controls | OR (95% CI) | ||||
|---|---|---|---|---|---|---|
| Frequency | Frequency | |||||
| AA | 43 | 0.225 | 54 | 0.251 | 1.0 (referent) | |
| AG | 99 | 0.518 | 119 | 0.554 | 1.465 (0.826-2.598) | 0.243 |
| GG | 49 | 0.257 | 42 | 0.195 | 1.045 (0.647-1.687) | 0.903 |
| AG+GG | 148 | 0.775 | 161 | 0.749 | 1.154 (0.731-1.823) | 0.562 |
| –181 A | 185 | 0.484 | 227 | 0.528 | 1.0 (referent) | |
| –181 G | 197 | 0.516 | 203 | 0.472 | 1.191 (0.904-1.569) | 0.232 |