<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Osteoprotegerin (OPG) has been demonstrated to be a novel biomarker for predicting prevalence and severity of coronary artery disease (CAD). Furthermore, recent studies have shown that <italic>OPG</italic> gene polymorphisms are associated with a susceptibility to CAD. However, published studies showed inconsistent results. Therefore, a meta-analysis of eligible studies reporting the association between <italic>OPG</italic> gene polymorphisms and CAD was carried out. A systematic search was conducted using PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Chinese Wan Fang databases. Odds ratio (OR) with corresponding 95% confidence interval (95% CI) were calculated. Overall, six eligible studies were included and four <italic>OPG</italic> gene polymorphisms (G209A, T245G, T950C and G1181C) were further evaluated for the association with susceptibility to CAD in this meta-analysis. Meta-analysis showed that G1181C and T950C polymorphisms were strongly associated with the risk of CAD, but no association existed between G209A and T245G polymorphisms and the risk of CAD. In conclusion, our meta-analysis is the first report to estimate the association between <italic>OPG</italic> gene polymorphisms and susceptibility to CAD. Further large scale case-control studies with rigorous design should be conducted to confirm the above conclusions in the future.</p></abstract>

Osteoprotegerin (OPG) has been demonstrated to be a novel biomarker for predicting prevalence and severity of coronary artery disease (CAD). Furthermore, recent studies have shown that OPG gene polymorphisms are associated with a susceptibility to CAD. However, published studies showed inconsistent results. Therefore, a meta-analysis of eligible studies reporting the association between OPG gene polymorphisms and CAD was carried out. A systematic search was conducted using PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Chinese Wan Fang databases. Odds ratio (OR) with corresponding 95% confidence interval (95% CI) were calculated. Overall, six eligible studies were included and four OPG gene polymorphisms (G209A, T245G, T950C and G1181C) were further evaluated for the association with susceptibility to CAD in this meta-analysis. Meta-analysis showed that G1181C and T950C polymorphisms were strongly associated with the risk of CAD, but no association existed between G209A and T245G polymorphisms and the risk of CAD. In conclusion, our meta-analysis is the first report to estimate the association between OPG gene polymorphisms and susceptibility to CAD. Further large scale case-control studies with rigorous design should be conducted to confirm the above conclusions in the future.

Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

Balkan Journal of Medical Genetics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Osteoprotegerin (OPG) has been demonstrated to be a novel biomarker for predicting prevalence and severity of coronary artery disease (CAD). Furthermore,...

Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

Article Category: Original Article

Published Online: Dec 29, 2017

Page range: 27 - 33

DOI: https://doi.org/10.1515/bjmg-2017-0021

Keywords
Coronary artery disease (CAD), Gene polymorphism, Meta-analysis, Osteoprotegerin (OPG)

© 2017 Jia P, Wu N, Jia D, Sun Y, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

Article Category: Original Article

Published Online: Dec 29, 2017

Page range: 27 - 33

DOI: https://doi.org/10.1515/bjmg-2017-0021

KeywordsCoronary artery disease (CAD), Gene polymorphism, Meta-analysis, Osteoprotegerin (OPG)

© 2017 Jia P, Wu N, Jia D, Sun Y, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Coronary artery disease (CAD), Gene polymorphism, Meta-analysis, Osteoprotegerin (OPG)