<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The determination of genetic background in metabolic syndrome (MetS) represents one of the necessary steps to prevent the disorder, thus reducing the cost of medical treatments and helping to design targeted therapy. The study explores the association between individual alleles of the <italic>LRP1</italic> gene and the diagnosis of MetS to find correlation between the low-density lipoprotein receptor-related (<italic>LRP1</italic>) gene polymorphism and each individual anthropometric and biochemical parameter. The study included 93 males and females, aged from 19 to 65, divided into two groups. The genotype of each person was determined from the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) profile. Results indicated the association of the T allele form of exon 3 <italic>LRP1</italic> gene with development and progression of MetS that further pointed out its negative impact on tested anthropometric and biochemical parameters. The presence of the T allele in patients multiplies the chance of occurrence of deviations from the reference values of body mass index (BMI), (4.24-fold) and low-density lipoprotein (LDL) (20.26-fold) compared to C allele carriers. The results showed that T allele presence multiplies the chance (4.76 fold) for the occurrence of MetS in comparison to C allele carriers. Correlation found that the T allele of the <italic>LRP1</italic> gene with MetS determinants is not negligible, therefore, the T allele may be considered as a risk factor for MetS development.</p>
</abstract>

The determination of genetic background in metabolic syndrome (MetS) represents one of the necessary steps to prevent the disorder, thus reducing the cost of medical treatments and helping to design targeted therapy. The study explores the association between individual alleles of the LRP1 gene and the diagnosis of MetS to find correlation between the low-density lipoprotein receptor-related (LRP1) gene polymorphism and each individual anthropometric and biochemical parameter. The study included 93 males and females, aged from 19 to 65, divided into two groups. The genotype of each person was determined from the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) profile. Results indicated the association of the T allele form of exon 3 LRP1 gene with development and progression of MetS that further pointed out its negative impact on tested anthropometric and biochemical parameters. The presence of the T allele in patients multiplies the chance of occurrence of deviations from the reference values of body mass index (BMI), (4.24-fold) and low-density lipoprotein (LDL) (20.26-fold) compared to C allele carriers. The results showed that T allele presence multiplies the chance (4.76 fold) for the occurrence of MetS in comparison to C allele carriers. Correlation found that the T allele of the LRP1 gene with MetS determinants is not negligible, therefore, the T allele may be considered as a risk factor for MetS development.

The <italic>LRP1</italic> gene polymorphism is associated with increased risk of metabolic syndrome prevalence in the Serbian population

Balkan Journal of Medical Genetics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The  gene polymorphism is associated with increased risk of metabolic syndrome prevalence in the Serbian population

The determination of genetic background in metabolic syndrome (MetS) represents one of the necessary steps to prevent the disorder, thus reducing the cost of...

The LRP1 gene polymorphism is associated with increased risk of metabolic syndrome prevalence in the Serbian population

Article Category: Original Article

Published Online: Jun 30, 2017

Page range: 51 - 58

DOI: https://doi.org/10.1515/bjmg-2017-0004

Keywords
Genetic predisposition, Lipid metabolism, Low-density lipoprotein receptor-related () gene polymorphism, Metabolic syndrome (MetS), T allele

© 2017 Vučinić N, Stokić E, Djan I, Obreht D, Veličković N, Stankov K, Djan M

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The LRP1 gene polymorphism is associated with increased risk of metabolic syndrome prevalence in the Serbian population

Article Category: Original Article

Published Online: Jun 30, 2017

Page range: 51 - 58

DOI: https://doi.org/10.1515/bjmg-2017-0004

KeywordsGenetic predisposition, Lipid metabolism, Low-density lipoprotein receptor-related () gene polymorphism, Metabolic syndrome (MetS), T allele

© 2017 Vučinić N, Stokić E, Djan I, Obreht D, Veličković N, Stankov K, Djan M

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Genetic predisposition, Lipid metabolism, Low-density lipoprotein receptor-related () gene polymorphism, Metabolic syndrome (MetS), T allele