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Gardiner SJ, Begg EJ. Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev. 2006; 58(3): 521-590.GardinerSJBeggEJPharmacogenetics, drug-metabolizing enzymes, and clinical practicePharmacol Rev200658352159010.1124/pr.58.3.6Search in Google Scholar
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004; 14(1): 1-18.NelsonDRZeldinDCHoffmanSMMaltaisLJWainHMNebertDWComparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variantsPharmacogenetics200414111810.1097/00008571-200401000-00001Search in Google Scholar
Kimura S, Umeno M, Skoda RC, Meyer UA, Gonazalez FJ. The human debrisoquine 4-hydrolase(CYP2D)locus:Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet. 1989; 45(6): 889-904.KimuraSUmenoMSkodaRCMeyerUAGonazalezFJThe human debrisoquine 4-hydrolase(CYP2D)locus:Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogeneAm J Hum Genet1989456889904Search in Google Scholar
The Human Cytochrome P450 (CYP) Allele Nomenclature committee. (http://www.cypalleles. ki.se/ cyp2d6.htm)The Human Cytochrome P450 (CYP) Allele Nomenclature committee. (http://www.cypalleles. ki.se/ cyp2d6.htm)Search in Google Scholar
Steen VM, Andreassen OA, Daly AK, Tefre T, Borresen A-L, Idle JR, et al. Detection of the poor metab-olizer-associated CYP2D6(D) gene deletion allele by long-PCR technology. Pharmacogenetics. 1995; 5(4): 215-223.SteenVMAndreassenOADalyAKTefreTBorresenA-LIdleJRet alDetection of the poor metab-olizer-associated CYP2D6(D) gene deletion allele by long-PCR technologyPharmacogenetics19955421522310.1097/00008571-199508000-00005Search in Google Scholar
Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA. 1993; 90(24): 11825-11829.JohanssonILundqvistEBertilssonLDahlMLSjoqvistFIngelman-SundbergMInherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquineProc Natl Acad Sci USA19939024118251182910.1073/pnas.90.24.11825Search in Google Scholar
The Pharmacogenomics Knowledge Base (PharmGKB) (https://www.pharmgkb.org/page/cpic).The Pharmacogenomics Knowledge Base (PharmGKB) (https://www.pharmgkb.org/page/cpic)Search in Google Scholar
Evans WE, Relling MV. Moving towards individualized medicine with pharmacogenomics. Nature. 2004; 429(6990): 464-468.EvansWERellingMVMoving towards individualized medicine with pharmacogenomicsNature2004429699046446810.1038/nature02626Search in Google Scholar
Ma MK, Woo MH, McLeod HL. Genetic basis of drug metabolism. Am J Health Syst Pharm. 2002; 59(21): 2061-2069.MaMKWooMHMcLeodHLGenetic basis of drug metabolismAm J Health Syst Pharm200259212061206910.1093/ajhp/59.21.2061Search in Google Scholar
Ingelman-Sundberg M, Oscarson M, McLellan RA. Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment. Trends Pharmacol Sci. 1999; 20(8): 342-349.Ingelman-SundbergMOscarsonMMcLellanRAPolymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatmentTrends Pharmacol Sci199920834234910.1016/S0165-6147(99)01363-2Search in Google Scholar
Meyer UA. Pharmacogenetics – five decades of therapeutic lessons from genetic diversity. Nat Rev Genet. 2004; 5(9): 669-676.MeyerUAPharmacogenetics – five decades of therapeutic lessons from genetic diversity. Nat Rev Genet20045966967610.1038/nrg1428Search in Google Scholar
Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics. 2002; 3(2): 229-243.BradfordLDCYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics20023222924310.1517/14622416.3.2.229Search in Google Scholar
Tateishi T, Chida M, Ariyoshi N, Mizorogi Y, Kamataki T, Kobayashi S. Analysis of the CYP2D6 gene in relation to dextromethorphan Odemethylation capacity in a Japanese population. Clin Pharmacol Ther. 1999; 65(5): 570-575.TateishiTChidaMAriyoshiNMizorogiYKamatakiTKobayashiSAnalysis of the CYP2D6 gene in relation to dextromethorphan Odemethylation capacity in a Japanese populationClin Pharmacol Ther199965557057510.1016/S0009-9236(99)70077-9Search in Google Scholar
Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Phar-macogenetics. 1999; 9(6): 669-682.GaedigkAGotschallRRForbesNSSimonSDKearnsGLLeederJSOptimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency dataPhar-macogenetics199996669682Search in Google Scholar
Sistonen J, Sajantila A, Lao O, Corander J, Barbujani G, Fuselli S. CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet Genomics. 2007; 17(2): 93-101.SistonenJSajantilaALaoOCoranderJBarbujaniGFuselliSCYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structurePharmacogenet Genomics20071729310110.1097/01.fpc.0000239974.69464.f2Search in Google Scholar
Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 2004; 5(1): 6-13.Ingelman-SundbergMGenetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversityPharmacogenomics J20045161310.1038/sj.tpj.6500285Search in Google Scholar
Soderback E, Zackrisson AL, Lindblom B, Alderborn A. Determination of CYP2D6 gene copy number by pyrosequencing. Clin Chem. 2005; 51(3): 522-531.SoderbackEZackrissonALLindblomBAlderbornADetermination of CYP2D6 gene copy number by pyrosequencingClin Chem200551352253110.1373/clinchem.2004.043182Search in Google Scholar
Lundqvist E, Johansson I, Ingelman-Sundberg M. Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes. Gene. 1999; 226(2): 327-338LundqvistEJohanssonIIngelman-SundbergMGenetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genesGene199922622733810.1016/S0378-1119(98)00567-8Search in Google Scholar
Lindpaintner K. Pharmacogenetics and the future of medical practice. Br J Clin Pharmacol. 2002; 54(2): 221-230.LindpaintnerKPharmacogenetics and the future of medical practice. Br J Clin Pharmacol200254222123010.1046/j.1365-2125.2002.01630.x187440212207645Search in Google Scholar
Kirchheiner J, Nickchen K, Bauer M, Wong ML, Licinio J, Roots I, et al. Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response (Review). Mol Psychiatry. 2004; 9(5): 442-473.KirchheinerJNickchenKBauerMWongMLLicinioJRootsIet alPharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response (Review)Mol Psychiatry20049544247310.1038/sj.mp.400149415037866Search in Google Scholar
Sistonen J, Fuselli S, Levo A, Sajantila A. CYP 2D6 genotyping by a multiplex primer extension reaction. Clin Chem. 2005; 51(7): 1291-1295.SistonenJFuselliSLevoASajantilaACYP 2D6 genotyping by a multiplex primer extension reactionClin Chem20055171291129510.1373/clinchem.2004.04646615905314Search in Google Scholar
Goddard KA, Hopkins PJ, Hall JM, Witte JS. Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymerphisms in five populations. Am J Hum Genet. 2000; 66(1): 216-234.GoddardKAHopkinsPJHallJMWitteJSLinkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymerphisms in five populationsAm J Hum Genet200066121623410.1086/302727128832810631153Search in Google Scholar
Rebsamen MC, Desmeules J, Daali Y, Chiappe A, Diemand A, Rey C, et al. The AmpliChip CYP450 test: Cytochrome P450 2D6 genotype assessment and phenotype prediction. Pharmacogenomics J. 2009; 9(1): 34-41.RebsamenMCDesmeulesJDaaliYChiappeADiemandAReyCet alThe AmpliChip CYP450 test: Cytochrome P450 2D6 genotype assessment and phenotype predictionPharmacogenomics J200991344110.1038/tpj.2008.718591960Search in Google Scholar
Umamaheswaran G, Dhakchinamoorthi K, Chan-drasekaran A. Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters – a review with Indian perspective. Indian J Med Res. 2014; 139(1): 27-65.UmamaheswaranGDhakchinamoorthiKChandrasekaranADistribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters – a review with Indian perspectiveIndian J Med Res201413912765Search in Google Scholar
Al-Dosari M, Al-Jenoobi F, Alkharfy K, Alghamdi A, Bagulb K, Parvez M, et al. High prevalence of CYP 2D6*41 (G2988A) allele in Saudi Arabians. Environ Toxicol Pharmacol. 2013; 36(3): 1063-1067. 10.1016/j. etap.2013.09.008.Al-DosariMAl-JenoobiFAlkharfyKAlghamdiABagulbKParvezMet alHigh prevalence of CYP 2D6*41 (G2988A) allele in Saudi ArabiansEnviron Toxicol Pharmacol20133631063106710.1016/j. etap.2013.09.00810.1016/j.etap.2013.09.00824121619Search in Google Scholar
Qumsieh RY, Ali BR, Abdulrazzaq YM, Osman O, Akawi NA, Bastaki SMA. Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis. PLoS ONE. 2011; 6(12): e28943. 10.1371/journal.pone.0028943.QumsiehRYAliBRAbdulrazzaqYMOsmanOAkawiNABastakiSMAIdentification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in EmiratisPLoS ONE2011612e2894310.1371/journal.pone.002894310.1371/journal.pone.0028943324523522216145Search in Google Scholar
Kapedanovska NestorovskaA, Jakovski K, Naumovska Z, Hiljadnikova Bajro M, Sterjev Z, Eftimov A, et al. Distribution of the most common genetic variants associated with a variable drug response in the population of the Republic of Macedonia. Balkan J Med Genet. 2014; 17(2): 5-14. 10.2478/bjmg-2014-0069KapedanovskaNestorovskaAJakovskiKNaumovskaZHiljadnikova BajroMSterjevZEftimovAet alDistribution of the most common genetic variants associated with a variable drug response in the population of the Republic of MacedoniaBalkan J Med Genet201417251410.2478/bjmg-2014-006910.2478/bjmg-2014-0069441343725937793Search in Google Scholar
Chou WH1, Yan FX, de Leon J, Barnhill J, Rogers T, Cronin M, et al. Extension of a pilot study: Impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness. J Clin Psychopharmacol. 2000; 20(2): 246-251.ChouWH1YanFXde LeonJBarnhillJRogersTCroninMet alExtension of a pilot study: Impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illnessJ Clin Psychopharmacol200020224625110.1097/00004714-200004000-0001910770465Search in Google Scholar
Bozina N, Granić P, Lalić Z, Tramisak I, Lovrić M, Stavljenić-Rukavina A. Genetic polymorphisms of cytochromes P450: CYP2C9, CYP2C19, and CYP2D6 in Croatian population. Croat Med J. 2003; 44(4): 425-428.BozinaNGranićPLalićZTramisakILovrićMStavljenić-RukavinaAGenetic polymorphisms of cytochromes P450: CYP2C9, CYP2C19, and CYP2D6 in Croatian populationCroat Med J2003444425428Search in Google Scholar
Arvanitidis K, Ragia G, Iordanidou M, Kyriaki S, Xanthi A, Tavridou A, et al. Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population. Fundam Clin Pharmacol. 2007; 21(4): 419-426.ArvanitidisKRagiaGIordanidouMKyriakiSXanthiATavridouAet alGenetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek populationFundam Clin Pharmacol200721441942610.1111/j.1472-8206.2007.00510.x17635181Search in Google Scholar
Buzková H, Pechandová K, Slanar O, Perlik F. Frequency of single nucleotide polymorphisms of CYP-2D6 in the Czech population. Cell Biochem Funct. 2008; 26(1): 76-81.BuzkováHPechandováKSlanarOPerlikFFrequency of single nucleotide polymorphisms of CYP-2D6 in the Czech populationCell Biochem Funct2008261768110.1002/cbf.140217311358Search in Google Scholar
Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences. Am J Hum Genet. 1997; 60(2): 284-295.SachseCBrockmollerJBauerSRootsICytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequencesAm J Hum Genet1997602284295Search in Google Scholar
