<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Changes in the concentration of melatonin and prolactin are associated with response to day length. The factors that stimulate the release of PRL include, among others, TRH, VIP, endorphins, oestrogen, and adrenaline. PRL secretion inhibitors include DA, GABA, progesterone and bromocriptine (exogenous compound), used in the treatment of hyperprolactinemia D2 receptor agonist. The biological activity of this compound is to stimulate dopamine D2 receptors in the pituitary, which inhibits PRL secretion via the tuberoinfundibular pathway (Fitzgerald and Dinan, 2008). In sheep treated with bromocriptine there is a decrease in PRL concentration and an increase in the sensitivity of cells producing LH to GnRH, but there is no disturbance in the course of the estrous cycle. Rams show decreased libido and changes in sexual behaviour. The administration of bromocriptine throughout the period of sexual activity and the period of rearing offspring affects maternal instinct, which involves the inhibition of PRL secretion. It is not clarified whether the effect of bromocriptine on sexual behaviour is associated with its direct impact on behavioural centres in the brain, or indirectly through the regulation of PRL secretion. However, the seasonal variations in the effects of bromocriptine on sexual behaviour can strengthen the hypothesis that the effect of bromocriptine on sexual development behaviour is associated with changes in the intensity of PRL secretion rather than by the inhibition of behavioural bromocriptine brain centres. The process of regulation of prolactin secretion by bromocriptine requires further examination.</p></abstract>

Changes in the concentration of melatonin and prolactin are associated with response to day length. The factors that stimulate the release of PRL include, among others, TRH, VIP, endorphins, oestrogen, and adrenaline. PRL secretion inhibitors include DA, GABA, progesterone and bromocriptine (exogenous compound), used in the treatment of hyperprolactinemia D2 receptor agonist. The biological activity of this compound is to stimulate dopamine D2 receptors in the pituitary, which inhibits PRL secretion via the tuberoinfundibular pathway (Fitzgerald and Dinan, 2008). In sheep treated with bromocriptine there is a decrease in PRL concentration and an increase in the sensitivity of cells producing LH to GnRH, but there is no disturbance in the course of the estrous cycle. Rams show decreased libido and changes in sexual behaviour. The administration of bromocriptine throughout the period of sexual activity and the period of rearing offspring affects maternal instinct, which involves the inhibition of PRL secretion. It is not clarified whether the effect of bromocriptine on sexual behaviour is associated with its direct impact on behavioural centres in the brain, or indirectly through the regulation of PRL secretion. However, the seasonal variations in the effects of bromocriptine on sexual behaviour can strengthen the hypothesis that the effect of bromocriptine on sexual development behaviour is associated with changes in the intensity of PRL secretion rather than by the inhibition of behavioural bromocriptine brain centres. The process of regulation of prolactin secretion by bromocriptine requires further examination.

The Role of Melatonin and Bromocriptine in the Regulation of Prolactin Secretion in Animals – A Review

Department of Animal Biotechnology, Agricultural University in Krakow, Mickiewicza 21, 31-120 Kraków, Poland

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Changes in the concentration of melatonin and prolactin are associated with response to day length. The factors that stimulate the release of PRL include,...

The Role of Melatonin and Bromocriptine in the Regulation of Prolactin Secretion in Animals – A Review

Article Category: Review

Published Online: Oct 29, 2015

Page range: 849 - 860

Received: Dec 10, 2014

Accepted: Jun 08, 2015

DOI: https://doi.org/10.1515/aoas-2015-0042

Keywords
bromocriptine, prolactin, melatonin, seasonality

© by Edyta Molik

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The Role of Melatonin and Bromocriptine in the Regulation of Prolactin Secretion in Animals – A Review

Article Category: Review

Published Online: Oct 29, 2015

Page range: 849 - 860

Received: Dec 10, 2014

Accepted: Jun 08, 2015

DOI: https://doi.org/10.1515/aoas-2015-0042

Keywordsbromocriptine, prolactin, melatonin, seasonality

© by Edyta Molik

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
bromocriptine, prolactin, melatonin, seasonality