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Lacosamide Reduces Seizure Severity but Increases Seizure Frequency in PTZ-Kindled Rats


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1. Errington AC, Stohr T, Heers C, Lees G – The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels. Mol Pharmacol 2008;73(1):157–169.10.1124/mol.107.039867Search in Google Scholar

2. Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C – Current understanding of the mechanism of action of the antiepileptic drug lacosamide. Epilepsy Res 2015;110:189–205.10.1016/j.eplepsyres.2014.11.021Search in Google Scholar

3. Wilson SM, Xiong W, Wang Y, et al. – Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization. Neuroscience 2012;210:451–466.10.1016/j.neuroscience.2012.02.038Search in Google Scholar

4. Wilson SM, Khanna R – Specific Binding of Lacosamide to Collapsin Response Mediator Protein 2 (CRMP2) and Direct Impairment of its Canonical Function: Implications for the Therapeutic Potential of Lacosamide. Mol Neurobiol 2015;51(2):599–609.10.1007/s12035-014-8775-9Search in Google Scholar

5. Stöhr T, Kupferberg HJ, Stables JP, et al. – Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res 2007;74(2–3):147–154.10.1016/j.eplepsyres.2007.03.004Open DOISearch in Google Scholar

6. Coppola G, Arcieri S, D’Aniello A, et al. – Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. Seizure 2010;19(5):296–299.10.1016/j.seizure.2010.03.004Open DOISearch in Google Scholar

7. Andrews JS, Turski L, Stephens DN – Does the pentylenetetrazole (PTZ) cue reflect PTZ-induced kindling or PTZ-induced anxiogenesis? Drug Dev Res 1989;16(2–4):247–256.10.1002/ddr.430160218Open DOISearch in Google Scholar

8. Szyndler J, Rok P, Maciejak P, et al. – Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems 2002;73:851–861.Search in Google Scholar

9. Morimoto K – Seizure-triggering mechanisms in the kindling model of epilepsy: Collapse of GABA-mediated inhibition and activation of NMDA receptors. Neurosci Biobehav Rev 1989;13(4):253–260.10.1016/S0149-7634(89)80060-0Search in Google Scholar

10. Pavlova TV, Yakovlev AA, Stepanichev MY, Gulyaeva NV – Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity? Neurosci Behav Physiol 2006;36(7):741–748.10.1007/s11055-006-0082-016841155Search in Google Scholar

11. Davoudi M, Shojaei A, Palizvan MR, Javan M, Mirnajafi-Zadeh J – Comparison between standard protocol and a novel window protocol for induction of pentylenetetrazol kindled seizures in the rat. Epilepsy Res 2013;106(1–2):54–63.10.1016/j.eplepsyres.2013.03.01623619005Search in Google Scholar

12. Ergul Erkec O – Pentylenetetrazol Kindling Epilepsy Model. J Turkish Epilepsi Soc 2015;21(1):6–12.Search in Google Scholar

13. Hui Yin Y, Ahmad N, Makmor-Bakry M – Pathogenesis of epilepsy: challenges in animal models. Iran J Basic Med Sci 2013;16(11):1119–1132.Search in Google Scholar

14. Shandra AA, Godlevsky LS – Pentylenetetrazol-Induced Kindling as a Model of Absence and Convulsive forms of Epilepsy, in Corcoran ME, Moshé SL (eds): Kindling 6. Adv. Behav. Biol., Boston, MA: Springer US; 2005, 49–59.10.1007/0-387-26144-3_6Open DOISearch in Google Scholar

15. Ito T, Hori M, Yoshida K, Shimizu M – Effect of anticonvulsants on seizures developing in the course of daily administration of pentetrazol to rats. Eur J Pharmacol 1977;45(2):165–172.10.1016/0014-2999(77)90086-3Open DOISearch in Google Scholar

16. Gáll Z, Orbán-Kis K, Szilágyi T – Differential effects of sodium channel blockers on in vitro induced epileptiform activities. Arch Pharm Res 2017;40(1):112–121.10.1007/s12272-015-0676-626515967Open DOISearch in Google Scholar

17. Brandt C, Heile A, Potschka H, Stoehr T, Löscher W – Effects of the novel antiepileptic drug lacosamide on the development of amygdala kindling in rats. Epilepsia 2006;47(11):1803–1809.10.1111/j.1528-1167.2006.00818.x17116018Search in Google Scholar

18. Gayatri N, Livingston J – Aggravation of epilepsy by antiepileptic drugs. Dev Med Child Neurol 2006;48(5):394–398.10.1017/S001216220600084316608550Open DOISearch in Google Scholar

eISSN:
2247-6113
Language:
English
Publication timeframe:
6 times per year
Journal Subjects:
Medicine, Clinical Medicine, other