<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Objective: The study aimed at obtaining and characterizing levofloxacin-loaded, poly(ε-caprolactone) electrospun nanofiber formulations to be used as antibacterial wound dressings. Methods: Drug-loaded nanofibers were obtained by the electrospinning process and their morphology was determined using scanning electron microscopy. Structural analysis of the prepared nanofibers was carried out using differential scanning calorimetry and dissolution testing was performed in order to determine drug release. Results: Both nanofiberous formulations (containing 20 % and 50 % w/w levofloxacin) showed dimensions in the range of few hundred nanometers. Thermograms indicated that the formulation containing 20% levofloxacin was totally amorphized, showing a rapid release of the active, in 20 minutes. Conclusions: The poly(ε-caprolactone)-based electrospun nanofibers, containing levofloxacin presented suitable characteristics for obtaining potential antibacterial wound dressings.</p></abstract>

Objective: The study aimed at obtaining and characterizing levofloxacin-loaded, poly(ε-caprolactone) electrospun nanofiber formulations to be used as antibacterial wound dressings. Methods: Drug-loaded nanofibers were obtained by the electrospinning process and their morphology was determined using scanning electron microscopy. Structural analysis of the prepared nanofibers was carried out using differential scanning calorimetry and dissolution testing was performed in order to determine drug release. Results: Both nanofiberous formulations (containing 20 % and 50 % w/w levofloxacin) showed dimensions in the range of few hundred nanometers. Thermograms indicated that the formulation containing 20% levofloxacin was totally amorphized, showing a rapid release of the active, in 20 minutes. Conclusions: The poly(ε-caprolactone)-based electrospun nanofibers, containing levofloxacin presented suitable characteristics for obtaining potential antibacterial wound dressings.

Preparation and Characterization of Levofloxacin-Loaded Nanofibers as Potential Wound Dressings

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Objective: The study aimed at obtaining and characterizing levofloxacin-loaded, poly(ε-caprolactone) electrospun nanofiber formulations to be used as...

Preparation and Characterization of Levofloxacin-Loaded Nanofibers as Potential Wound Dressings

Article Category: Research Article

Published Online: Jul 08, 2017

Page range: 66 - 69

Received: Mar 01, 2017

Accepted: Apr 26, 2017

DOI: https://doi.org/10.1515/amma-2017-0014

Keywords
electrospinning, polymer, scanning electron microscopy, differential scanning calorimetry

© by Emese Sipos

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Preparation and Characterization of Levofloxacin-Loaded Nanofibers as Potential Wound Dressings

Article Category: Research Article

Published Online: Jul 08, 2017

Page range: 66 - 69

Received: Mar 01, 2017

Accepted: Apr 26, 2017

DOI: https://doi.org/10.1515/amma-2017-0014

Keywordselectrospinning, polymer, scanning electron microscopy, differential scanning calorimetry

© by Emese Sipos

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
electrospinning, polymer, scanning electron microscopy, differential scanning calorimetry