<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objective</bold>: The aim of this study was to evaluate how the membrane transport of diclofenac on presence of different types of food is modified.<bold>Methods</bold>: The interaction of diclofenac, as a pure substance and solid dispersions of the active ingredient, with different types of foods was investigated in vitro condition using a modified Franz diffusion cell.<bold>Results</bold>: The amount of diclofenac transported through a lipophilic membrane was reduced by the presence of foodstuffs in artificial gastric juice and intestinal juice also, both in the case of the pure substance and solid dispersions also. The only exception was the case of milk in artificial gastric juice, when the amount of diclofenac in the receiving compartment increased about 2-fold compared to the fasted conditions simulating media. In the case of the solid dispersions of diclofenac the membrane transport increased in all cases compared to the pure substance, but was also reduced by the foods.<bold>Conclusions</bold>: It was concluded that, the presence of different foodstuffs can influence the membrane transport of diclofenac – by inhibiting its solubility – and these differences observed in vitro can lead to modifications in the in vivo pharmacokinetic parameters. The lowest difference in diclofenac membrane transport was observed in the case of diclofenac:PEG 6000 solid dispersion prepared in 1:5 mass ratio.</abstract>

Objective: The aim of this study was to evaluate how the membrane transport of diclofenac on presence of different types of food is modified.Methods: The interaction of diclofenac, as a pure substance and solid dispersions of the active ingredient, with different types of foods was investigated in vitro condition using a modified Franz diffusion cell.Results: The amount of diclofenac transported through a lipophilic membrane was reduced by the presence of foodstuffs in artificial gastric juice and intestinal juice also, both in the case of the pure substance and solid dispersions also. The only exception was the case of milk in artificial gastric juice, when the amount of diclofenac in the receiving compartment increased about 2-fold compared to the fasted conditions simulating media. In the case of the solid dispersions of diclofenac the membrane transport increased in all cases compared to the pure substance, but was also reduced by the foods.Conclusions: It was concluded that, the presence of different foodstuffs can influence the membrane transport of diclofenac – by inhibiting its solubility – and these differences observed in vitro can lead to modifications in the in vivo pharmacokinetic parameters. The lowest difference in diclofenac membrane transport was observed in the case of diclofenac:PEG 6000 solid dispersion prepared in 1:5 mass ratio.

In Vitro Interactions of Diclofenac with Several Types of Food

University of Medicine and Pharmacy of Tirgu Mures,

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"In Vitro Interactions of Diclofenac with Several Types of Food"}

Objective: The aim of this study was to evaluate how the membrane transport of diclofenac on presence of different types of food is modified.Methods: The...

In Vitro Interactions of Diclofenac with Several Types of Food

Published Online: Oct 21, 2016

Page range: 334 - 338

Received: Jun 06, 2016

Accepted: Jul 11, 2016

DOI: https://doi.org/10.1515/amma-2016-0030

Keywords
food-drug interaction, diclofenac, in vitro, membrane transport

© 2016 Fülöp Ibolya et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In Vitro Interactions of Diclofenac with Several Types of Food

Published Online: Oct 21, 2016

Page range: 334 - 338

Received: Jun 06, 2016

Accepted: Jul 11, 2016

DOI: https://doi.org/10.1515/amma-2016-0030

Keywordsfood-drug interaction, diclofenac, in vitro, membrane transport

© 2016 Fülöp Ibolya et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
food-drug interaction, diclofenac, in vitro, membrane transport