<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Objective: The aim of this study was to evaluate the prevalence of aspirin non-responsiveness using whole blood multiple electrode aggregometry and to investigate the role of different clinical and laboratory variables associated with the lack of response. Methods: The present study included 116 aspirin treated patients presented with acute coronary syndromes or stroke. Response to aspirin was assessed by impedance aggregometry using arachidonic acid as agonist, in a final concentration of 0.5 mM (ASPI test). Results: In our data set 81% (n=94) were responders and 19% (n=22) non-responders showing high-on-aspirin platelet reactivity. Correlation analysis showed that the ward of admittance, low-density lipoproteins (LDL), concomitant antibiotic treatment, beta-adrenergic receptor blockers, history of myocardial infarction as well as PCI performed on Cardiology patients have different degrees of association with aspirin response. Conclusion: Concomitant treatment with beta-adrenergic receptor inhibitors, history of myocardial infarction and Cardiology ward admittance significantly increased the chance of responding to aspirin treatment whereas antibiotic therapy and low-density lipoproteins cholesterol seemed to increase the risk of high-on-aspirin residual platelet reactivity.</p></abstract>

Objective: The aim of this study was to evaluate the prevalence of aspirin non-responsiveness using whole blood multiple electrode aggregometry and to investigate the role of different clinical and laboratory variables associated with the lack of response. Methods: The present study included 116 aspirin treated patients presented with acute coronary syndromes or stroke. Response to aspirin was assessed by impedance aggregometry using arachidonic acid as agonist, in a final concentration of 0.5 mM (ASPI test). Results: In our data set 81% (n=94) were responders and 19% (n=22) non-responders showing high-on-aspirin platelet reactivity. Correlation analysis showed that the ward of admittance, low-density lipoproteins (LDL), concomitant antibiotic treatment, beta-adrenergic receptor blockers, history of myocardial infarction as well as PCI performed on Cardiology patients have different degrees of association with aspirin response. Conclusion: Concomitant treatment with beta-adrenergic receptor inhibitors, history of myocardial infarction and Cardiology ward admittance significantly increased the chance of responding to aspirin treatment whereas antibiotic therapy and low-density lipoproteins cholesterol seemed to increase the risk of high-on-aspirin residual platelet reactivity.

High-on-Aspirin Residual Platelet Reactivity Evaluated Using the Multiplate<sup>®</sup> Point-of-Care Device

University of Medicine and Pharmacy of Tîrgu Mureș, Romania

Emergency Military Hospital “Dr. Constantin Papilian” Cluj-Napoca, Romania

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

High-on-Aspirin Residual Platelet Reactivity Evaluated Using the Multiplate Point-of-Care Device

Objective: The aim of this study was to evaluate the prevalence of aspirin non-responsiveness using whole blood multiple electrode aggregometry and to...

High-on-Aspirin Residual Platelet Reactivity Evaluated Using the Multiplate^® Point-of-Care Device

Published Online: Feb 09, 2016

Page range: 101 - 105

Received: Sep 23, 2015

Accepted: Nov 05, 2015

DOI: https://doi.org/10.1515/amma-2015-0124

Keywords
aspirin, aspirin resistance, ischemic stroke, acute coronary syndrome, platelet function tests

© by Alina Mărginean

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

High-on-Aspirin Residual Platelet Reactivity Evaluated Using the Multiplate® Point-of-Care Device

Published Online: Feb 09, 2016

Page range: 101 - 105

Received: Sep 23, 2015

Accepted: Nov 05, 2015

DOI: https://doi.org/10.1515/amma-2015-0124

Keywordsaspirin, aspirin resistance, ischemic stroke, acute coronary syndrome, platelet function tests

© by Alina Mărginean

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

High-on-Aspirin Residual Platelet Reactivity Evaluated Using the Multiplate^® Point-of-Care Device

Keywords
aspirin, aspirin resistance, ischemic stroke, acute coronary syndrome, platelet function tests