<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Objective: The aim of the study was a comparative investigation by spectral and thermal analysis in order to asses a number of characteristics of different varieties ofrawmaterials of ursodeoxycholic acid and ibuprofen. The different dissolution behavior of two ursodeoxycholic acid pharmaceutical product by crystallinity pattern was investigated. Methods: Raw materials of ursodeoxycholic acid and ibuprofen were used. IR spectroscopy, differential scanning calorimetry and X-Ray Diffraction Analysis were applied. Results: The results show no crystallinitydifferences for different batches of the tested drugs. No solid solid transition was proved during sample preparation for transmission IR analysis. Conclusions: A combination of two more affordabletests by IR spectrometry and differential scanning calorimetry lead to the same results as X-Ray diffraction analysis for crystallinity similarity assessment of the studied substances. The dissolution differences of test drugs were not related to the polymorphism of the raw materials.</p></abstract>

Objective: The aim of the study was a comparative investigation by spectral and thermal analysis in order to asses a number of characteristics of different varieties ofrawmaterials of ursodeoxycholic acid and ibuprofen. The different dissolution behavior of two ursodeoxycholic acid pharmaceutical product by crystallinity pattern was investigated. Methods: Raw materials of ursodeoxycholic acid and ibuprofen were used. IR spectroscopy, differential scanning calorimetry and X-Ray Diffraction Analysis were applied. Results: The results show no crystallinitydifferences for different batches of the tested drugs. No solid solid transition was proved during sample preparation for transmission IR analysis. Conclusions: A combination of two more affordabletests by IR spectrometry and differential scanning calorimetry lead to the same results as X-Ray diffraction analysis for crystallinity similarity assessment of the studied substances. The dissolution differences of test drugs were not related to the polymorphism of the raw materials.

Internal Structure Quality Control of Solid Pharmaceuticals. A Comparative Study

University of Medicine and Pharmacy Tîrgu Mureş, Faculty of Pharmacy, Romania

“Babeş-Bolyai” University, Faculty of Physics & Interdisciplinary Research Institute on Bio-Nano-Sciences, Cluj-Napoca, Romania

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Internal Structure Quality Control of Solid Pharmaceuticals. A Comparative Study"}

Objective: The aim of the study was a comparative investigation by spectral and thermal analysis in order to asses a number of characteristics of different...

Internal Structure Quality Control of Solid Pharmaceuticals. A Comparative Study

Published Online: Feb 09, 2016

Page range: 95 - 100

Received: Aug 12, 2015

Accepted: Sep 05, 2015

DOI: https://doi.org/10.1515/amma-2015-0104

Keywords
IR spectroscopy, DSC, X-Ray Diffraction Analysis (XRD), ibuprofen, ursodeoxycholic acid

© by Silvia Imre

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Internal Structure Quality Control of Solid Pharmaceuticals. A Comparative Study

Published Online: Feb 09, 2016

Page range: 95 - 100

Received: Aug 12, 2015

Accepted: Sep 05, 2015

DOI: https://doi.org/10.1515/amma-2015-0104

KeywordsIR spectroscopy, DSC, X-Ray Diffraction Analysis (XRD), ibuprofen, ursodeoxycholic acid

© by Silvia Imre

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
IR spectroscopy, DSC, X-Ray Diffraction Analysis (XRD), ibuprofen, ursodeoxycholic acid