<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background and Aims</bold>. Gastric cancer, because of its aggressive evolution and the high mortality associated with it, remains one of the most debated subjects in medical literature with Helicobacter pylori (HP) as a major risk factor. Chronic inflammation caused by HP infection represents the initial site of the predisposing and afterwards premalignant lesions for gastric carcinoma. The purpose of this study was to evaluate the prevalence of HP infection, of predisposing and premalignant lesions on gastric biopsies, as well as to identify the correlations between them.<bold>Material and method</bold>. A retrospective cross-sectional study was performed on gastric biopsies collected endoscopically from a single region, antrum or corpus, and from different regions, between January 2012 and July 2014. Incidence of HP infection, of predisposing and premalignant gastric lesions, the correlation of HP infection and these lesions, were evaluated.<bold>Results</bold>. HP infection was diagnosed in 32.81%. Predisposing and premalignant lesions were present in 53.64% of biopsies with most of them in the antrum. HP infection stands out for the under 50 yo group (p=0.001). No correlation between frequency of HP infection and predisposing and premalignant lesions was observed.<bold>Conclusions</bold>. Prevalence of HP infection in our study suggests that besides HP infection, other factors are also involved in gastric cancer development. Biopsies from different regions of the gastric mucosa do not offer extra information regarding HP infection prevalence but may be helpful in evaluating incidence and extension of predisposing and premalignant lesions.</abstract>

Background and Aims. Gastric cancer, because of its aggressive evolution and the high mortality associated with it, remains one of the most debated subjects in medical literature with Helicobacter pylori (HP) as a major risk factor. Chronic inflammation caused by HP infection represents the initial site of the predisposing and afterwards premalignant lesions for gastric carcinoma. The purpose of this study was to evaluate the prevalence of HP infection, of predisposing and premalignant lesions on gastric biopsies, as well as to identify the correlations between them.Material and method. A retrospective cross-sectional study was performed on gastric biopsies collected endoscopically from a single region, antrum or corpus, and from different regions, between January 2012 and July 2014. Incidence of HP infection, of predisposing and premalignant gastric lesions, the correlation of HP infection and these lesions, were evaluated.Results. HP infection was diagnosed in 32.81%. Predisposing and premalignant lesions were present in 53.64% of biopsies with most of them in the antrum. HP infection stands out for the under 50 yo group (p=0.001). No correlation between frequency of HP infection and predisposing and premalignant lesions was observed.Conclusions. Prevalence of HP infection in our study suggests that besides HP infection, other factors are also involved in gastric cancer development. Biopsies from different regions of the gastric mucosa do not offer extra information regarding HP infection prevalence but may be helpful in evaluating incidence and extension of predisposing and premalignant lesions.

Helicobacter Pylori and its Determinations on Gastric Biopsies

Department of Histology, University of Medicine and Pharmacy of Tîrgu Mureş, Romania

Department of Epidemiology, University of Medicine and Pharmacy of Tîrgu Mureş, Romania

Department of Internal Medicine, University of Medicine and Pharmacy of Tîrgu Mureş, Romania

Department of Pathology, Emergency County Hospital of Tîrgu Mureş, Romania

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Helicobacter Pylori and its Determinations on Gastric Biopsies"}

Background and Aims. Gastric cancer, because of its aggressive evolution and the high mortality associated with it, remains one of the most debated subjects in...

Helicobacter Pylori and its Determinations on Gastric Biopsies

Published Online: Jan 19, 2016

Page range: 303 - 308

Received: Aug 14, 2015

Accepted: Sep 03, 2015

DOI: https://doi.org/10.1515/amma-2015-0066

Keywords
Helicobacter pylori infection, epidemiology, gastric cancer, risk factors, precursor lesions

© 2015 Fülöp Emöke et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Helicobacter Pylori and its Determinations on Gastric Biopsies

Published Online: Jan 19, 2016

Page range: 303 - 308

Received: Aug 14, 2015

Accepted: Sep 03, 2015

DOI: https://doi.org/10.1515/amma-2015-0066

KeywordsHelicobacter pylori infection, epidemiology, gastric cancer, risk factors, precursor lesions

© 2015 Fülöp Emöke et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Helicobacter pylori infection, epidemiology, gastric cancer, risk factors, precursor lesions