Maximizing the Amount of Deposited Particles During a Severe Asthma Attack Using the Stochastic Lung Model

1. ***Global Inititiative for Asthma. Global strategy for asthma management and prevention 2014. Available fromhttp://www.ginasthma.orgSearch in Google Scholar

2. Mitchell JP, Nagel MW, Wiersema KJ, Doyle CC. Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: Comparison of andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 aerodynamic particle sizer aerosol spectrometer. AAPS PharmSciTech, 2003;4:425-433.10.1208/pt040454275064715198549Search in Google Scholar

3. Usmani OS, Biddiscombe MF, Barnes PJ. Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med, 2005;172:1497-1504.10.1164/rccm.200410-1414OC16192448Search in Google Scholar

4. Saini D, Biris AS, Srirama PK, Mazumder MK. Particle size and charge distribution analysis of pharmaceutical aerosols generated by inhalers. Pharm Dev Technol, 2007;12:35-41.10.1080/1083745060116653617484142Search in Google Scholar

5. Zanen P, Go LT, Lammers JW. Optimal particle size for beta 2 agonist and anticholinergic aerosols in patients with severe airflow obstruction. Thorax, 1996 Oct;51:977-80.10.1136/thx.51.10.9774726438977595Search in Google Scholar

6. Usmani OS, Biddiscombe MF, Nightingale JA, Underwood SR, Barnes PJ. Effects of bronchodilator particle size in asthmatic patients using monodisperse aerosols. J Appl Physiol, 2003;95:2106-2112.10.1152/japplphysiol.00525.200312897033Search in Google Scholar

7. Zaninudin BMZ, Biddiscombe M, Tolfree SEJ, Short M, Spiro SG. Comparison of bronchodilator responses and deposition patterns of salbutamol inhaled from a pressurized metered dose inhaler, as a dry powder inhaler and as a nebulised solution. Thorax, 1990;45:469-473.10.1136/thx.45.6.4694625322392793Search in Google Scholar

8. Sárkány Z, Horvath A, Balashazy I, Hofmann W, Brinzaniuc K, Sabau M. Evaluation of inhaled drug deposition during an asthma attack using a stochastic lung model. Acta Medica Transilvanica, 2013;2:238-240.Search in Google Scholar

9. Dolovich M. Influence of inspiratory flow rate, particle size, and airway calibre on aerosolised drug delivery to the lung. Respir Care, 2000;45:597-608.Search in Google Scholar

10. Sárkány Z. Morfometria căilor respiratorii inferioare, utilitate în studii de modelare. PhD thesis, University of Medicine and Pharmacy of Târgu Mureș, Romania, 2013, pp. 75-80Search in Google Scholar

11. Oberdorster G. Pulmonary effects of inhaled ultrafine particles. International Archives ofOccupational and EnvironmentalHealth, 2001;74:1-8.Search in Google Scholar

12. Oberdorster G, Gelein RM, Ferin J, Weiss B. Associationof particulate air pollution and acute mortality: involvementof ultrafine particles? Inhalation Toxicology, 1995; 7:111-124.Search in Google Scholar

13. Oberdorster G, Maynard A, Donaldson K, et al. Principlesfor characterizing the potential human health effects fromexposure to nanomaterials: elements of a screening strategy. Particle and Fibre Toxicology, 2005; 2, article 8.10.1186/1743-8977-2-8126002916209704Search in Google Scholar

14. Pedata P, Garzillo EM, Sannolo N. Ultrafine particlesand effects on the organism: literature review. GiornaleItaliano di Medicina del Lavoro ed Ergonomia, 2010;32:23-31.Search in Google Scholar

15. Park SK, O’Neill MS, Vokonas PS, Sparrow D, Schwartz J. Effects of air pollution on heart rate variability: theVA normative aging study. Environmental Health Perspectives, 2005;113:304-309.10.1289/ehp.7447125375615743719Search in Google Scholar

16. Frampton MW, Utell MJ, Zareba W, et al. Effects ofexposure to ultrafine carbon particles in healthy subjects andsubjects with asthma. Research Report, 2004;126:1-47.Search in Google Scholar

17. Evans KA, Halterman JS, Hopke PK, Fagnano M, Rich DQ. Increased ultrafine particles and carbon monoxide concentrations are associated with asthma exacerbation among urban children. Environ Res, 2014;129:11-19.10.1016/j.envres.2013.12.001394788124528997Search in Google Scholar

18. Olvera HA, Perez D, Clague JW, et al. The Effect of Ventilation, Age, and AsthmaticCondition on Ultrafine Particle Deposition in Children. Pulmonary Medicine, vol. 2012, Article ID 736290, 9 pages, 2012. doi:10.1155/2012/73629010.1155/2012/736290340153122848818Search in Google Scholar

19. Crampton M1, Kinnersley R, Ayres J. Sub-micrometer particle production by pressurized metered dose inhalers. J Aerosol Med, 2004 Spring;17:33-42.10.1089/08942680432299444215120011Search in Google Scholar

20. Faiyazuddin M, Mujahid M, Hussain T, et al. Aerodynamics and deposition effects of inhaled submicron drug aerosol in airway diseases. Recent Pat Inflamm Allergy Drug Discov, 2013;7:49-61.10.2174/187221313804004691Search in Google Scholar