<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: The prostate cancer (PCa) is the second most common cancer amongst men. An elevated prostate specific antigen (PSA) level can lead to PCa suspition, thus the confirmation has to be a histopathological one. However, not all increased PSA level means prostate cancer. Material and Method: This retrospective study presents the results of 422 ultrasound guided prostate biopsy (PB) performed at the Clinic of Urology Târgu- Mureş, between 2011-2012. Inclusion criteria: patients with at least one negative PB and an elevated value of PSA. Results: In a two year period, from the total of 422 PB (100%), in 179 (42.42%) patients the histopathological result was “negative”. In 154 (86%) of cases ultrasound guided biopsies were performed, mostly with an initial 6 core (98- 54.74% of patients). Average PSA level was 13.45 ng/ml (0.49-100 ng/ml), the histological findings confirmed PCa in 52.58% cases, normal prostatic tissue in 141 cases (78.77%), atypical small acinar proliferation in 12 patients (6.70%), prostate atrophy in 11 males (6.14%), benign prostatic hyperplasia in 10 cases (5.59%) and prostatitis in 5 cases (2.80%). In 30 cases (16.75%) rebiopsy was performed with a number of 10- 12 cores. Conclusions: In order to increase PCa detection we should perform more cores during PB. In „negative” histopathological cases PSA should be monitorised and the biopsy should be repeated after 6 to 8 weeks from the initial biopsy. Patient’s compliance plays a vital role in the follow-up of the procedure</abstract>

Background: The prostate cancer (PCa) is the second most common cancer amongst men. An elevated prostate specific antigen (PSA) level can lead to PCa suspition, thus the confirmation has to be a histopathological one. However, not all increased PSA level means prostate cancer. Material and Method: This retrospective study presents the results of 422 ultrasound guided prostate biopsy (PB) performed at the Clinic of Urology Târgu- Mureş, between 2011-2012. Inclusion criteria: patients with at least one negative PB and an elevated value of PSA. Results: In a two year period, from the total of 422 PB (100%), in 179 (42.42%) patients the histopathological result was “negative”. In 154 (86%) of cases ultrasound guided biopsies were performed, mostly with an initial 6 core (98- 54.74% of patients). Average PSA level was 13.45 ng/ml (0.49-100 ng/ml), the histological findings confirmed PCa in 52.58% cases, normal prostatic tissue in 141 cases (78.77%), atypical small acinar proliferation in 12 patients (6.70%), prostate atrophy in 11 males (6.14%), benign prostatic hyperplasia in 10 cases (5.59%) and prostatitis in 5 cases (2.80%). In 30 cases (16.75%) rebiopsy was performed with a number of 10- 12 cores. Conclusions: In order to increase PCa detection we should perform more cores during PB. In „negative” histopathological cases PSA should be monitorised and the biopsy should be repeated after 6 to 8 weeks from the initial biopsy. Patient’s compliance plays a vital role in the follow-up of the procedure

The Management of the Patient with Elevated Prostate Specific Antigen and a Negative Initial Prostate Biopsy

Department of Urology, Mures County Hospital, Tîrgu Mureș

University of Medicine and Pharmacy, Tîrgu Mureș

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: The prostate cancer (PCa) is the second most common cancer amongst men. An elevated prostate specific antigen (PSA) level can lead to PCa...

The Management of the Patient with Elevated Prostate Specific Antigen and a Negative Initial Prostate Biopsy

Published Online: Jun 16, 2015

Page range: 7 - 9

Received: Jul 15, 2014

Accepted: Nov 04, 2014

DOI: https://doi.org/10.1515/amma-2015-0021

Keywords
prostate cancer, PSA, biopsy, atypical small acinar proliferation

© by A.O. Vida

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Management of the Patient with Elevated Prostate Specific Antigen and a Negative Initial Prostate Biopsy

Published Online: Jun 16, 2015

Page range: 7 - 9

Received: Jul 15, 2014

Accepted: Nov 04, 2014

DOI: https://doi.org/10.1515/amma-2015-0021

Keywordsprostate cancer, PSA, biopsy, atypical small acinar proliferation

© by A.O. Vida

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
prostate cancer, PSA, biopsy, atypical small acinar proliferation