<abstract xmlns="http://www.w3.org/1999/xhtml"> Objective: The aim of this study was to evaluate the impact of age, diabetes duration, glycaemic control, existence of cardiac autonomic neuropathy (CAN), retinopathy and of macroangiopathy on the peripheral nerve function in patients with type 2 diabetes. Methods: One hundred forty-nine type 2 diabetes mellitus patients were assessed with peripheral motor and sensory nerve conduction tests and cardiovascular reflex tests, as well as being evaluated for retinopathy, common carotid artery intimal-media-thickness (IMT) and anklebrachial index (ABI). Results: The duration of diabetes has the strongest effect in the reduction of the amplitude of motor response in the peroneal nerve and of the sensory amplitude in the sural nerve. The strongest correlations were found between glycaemic control and decreasing motor amplitude in the median nerve and sensory amplitude in the sural nerve, respectively. The motor and sensory nerve action potential amplitudes were significantly affected in the group of patients with CAN. According to multivariate logistic regression analysis, duration of diabetes and presence of CAN were the most important factors that influenced the motor and sensory nerve function. Conclusion: The presence of CAN together with diabetes duration and poor glycaemic control were associated with impaired peripheral nerve function, while macroangiopathy does not seem to be associated with the impairment of these electrophysiological parameters.</abstract>

Objective: The aim of this study was to evaluate the impact of age, diabetes duration, glycaemic control, existence of cardiac autonomic neuropathy (CAN), retinopathy and of macroangiopathy on the peripheral nerve function in patients with type 2 diabetes. Methods: One hundred forty-nine type 2 diabetes mellitus patients were assessed with peripheral motor and sensory nerve conduction tests and cardiovascular reflex tests, as well as being evaluated for retinopathy, common carotid artery intimal-media-thickness (IMT) and anklebrachial index (ABI). Results: The duration of diabetes has the strongest effect in the reduction of the amplitude of motor response in the peroneal nerve and of the sensory amplitude in the sural nerve. The strongest correlations were found between glycaemic control and decreasing motor amplitude in the median nerve and sensory amplitude in the sural nerve, respectively. The motor and sensory nerve action potential amplitudes were significantly affected in the group of patients with CAN. According to multivariate logistic regression analysis, duration of diabetes and presence of CAN were the most important factors that influenced the motor and sensory nerve function. Conclusion: The presence of CAN together with diabetes duration and poor glycaemic control were associated with impaired peripheral nerve function, while macroangiopathy does not seem to be associated with the impairment of these electrophysiological parameters.

Influence of Risk Factors and Diabetic Complications on Peripheral Nerve Function in Type 2 Diabetes Mellitus

University of Medicine and Pharmacy Târgu Mureş, Department of Neurology, Tîrgu Mureş, Romania

University of Medicine and Pharmacy Târgu Mureş, Department of Epidemiology, Tîrgu Mureş, Romania

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objective: The aim of this study was to evaluate the impact of age, diabetes duration, glycaemic control, existence of cardiac autonomic neuropathy (CAN),...

Influence of Risk Factors and Diabetic Complications on Peripheral Nerve Function in Type 2 Diabetes Mellitus

Published Online: Jun 16, 2015

Page range: 40 - 46

Received: Jan 05, 2015

Accepted: Jan 14, 2015

DOI: https://doi.org/10.1515/amma-2015-0015

Keywords
electrophysiological parameters, motor and sensory nerve function, cardiac autonomic neuropathy, glycaemic control, diabetes duration, macroangiopathy

© by Anca Moțățăianu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Influence of Risk Factors and Diabetic Complications on Peripheral Nerve Function in Type 2 Diabetes Mellitus

Published Online: Jun 16, 2015

Page range: 40 - 46

Received: Jan 05, 2015

Accepted: Jan 14, 2015

DOI: https://doi.org/10.1515/amma-2015-0015

Keywordselectrophysiological parameters, motor and sensory nerve function, cardiac autonomic neuropathy, glycaemic control, diabetes duration, macroangiopathy

© by Anca Moțățăianu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
electrophysiological parameters, motor and sensory nerve function, cardiac autonomic neuropathy, glycaemic control, diabetes duration, macroangiopathy