<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Dispersion of multilamellar liposomes of dimyristoylphosphatidylcholine (DMPC) and cholesterol (CHOL) were studied by vibrational densitometer for the CHOL mole fractions X = 0−0.54 in the temperature range 18−50 °C, both below and above the main phase transition. DMPC-CHOL bilayers served as a simple model for lipidic part of biological membrane. Volumetric parameters are essential not only to evaluate the data obtained by scattering and diffraction methods on model membranes but can provide valuable information about molecular packing in bilayers and the phase behaviour of lipid-CHOL mixtures. In this paper, preliminary results regarding the changes in the specific volume of lipid bilayer with increasing temperature and CHOL content are presented. Different values of apparent molecular volume of CHOL for different CHOL mole fraction pointed out the non-ideal mixing of DMPC and CHOL.</p></abstract>

Dispersion of multilamellar liposomes of dimyristoylphosphatidylcholine (DMPC) and cholesterol (CHOL) were studied by vibrational densitometer for the CHOL mole fractions X = 0−0.54 in the temperature range 18−50 °C, both below and above the main phase transition. DMPC-CHOL bilayers served as a simple model for lipidic part of biological membrane. Volumetric parameters are essential not only to evaluate the data obtained by scattering and diffraction methods on model membranes but can provide valuable information about molecular packing in bilayers and the phase behaviour of lipid-CHOL mixtures. In this paper, preliminary results regarding the changes in the specific volume of lipid bilayer with increasing temperature and CHOL content are presented. Different values of apparent molecular volume of CHOL for different CHOL mole fraction pointed out the non-ideal mixing of DMPC and CHOL.

Partial molecular volumes of cholesterol and phosphatidylcholine in mixed bilayers

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Dispersion of multilamellar liposomes of dimyristoylphosphatidylcholine (DMPC) and cholesterol (CHOL) were studied by vibrational densitometer for the CHOL...

Partial molecular volumes of cholesterol and phosphatidylcholine in mixed bilayers

Published Online: Nov 30, 2017

Page range: 1 - 3

Received: Jun 22, 2016

Accepted: Jul 19, 2016

DOI: https://doi.org/10.1515/afpuc-2017-0012

Keywords
cholesterol, dimyristoylphosphatidylcholine, specific volume, densitometry

© by J. Gallová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Partial molecular volumes of cholesterol and phosphatidylcholine in mixed bilayers

Published Online: Nov 30, 2017

Page range: 1 - 3

Received: Jun 22, 2016

Accepted: Jul 19, 2016

DOI: https://doi.org/10.1515/afpuc-2017-0012

Keywordscholesterol, dimyristoylphosphatidylcholine, specific volume, densitometry

© by J. Gallová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
cholesterol, dimyristoylphosphatidylcholine, specific volume, densitometry