<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The effect of general anaesthetics alkan-1-ols (CnOH, where n = 10, 12, 14, 16 and 18 is the number of carbon atoms in the molecule) on the structure of dioleoylphosphatidylcholine (DOPC) model membrane was studied by small-angle neutron scattering (SANS) and small-angle neutron diffraction (SAND). Fluid bilayers were prepared at CnOH:DOPC = 0.3 molar ratio. The results of both the experiments show that bilayer thickness - a thickness parameter dg in the case of SANS and lamellar repeat distance D in the case of SAND - increases with increasing n. A coexistence of two lamellar phases with different D was detected by measuring the C18OH+DOPC oriented sample.</p></abstract>

The effect of general anaesthetics alkan-1-ols (CnOH, where n = 10, 12, 14, 16 and 18 is the number of carbon atoms in the molecule) on the structure of dioleoylphosphatidylcholine (DOPC) model membrane was studied by small-angle neutron scattering (SANS) and small-angle neutron diffraction (SAND). Fluid bilayers were prepared at CnOH:DOPC = 0.3 molar ratio. The results of both the experiments show that bilayer thickness - a thickness parameter dg in the case of SANS and lamellar repeat distance D in the case of SAND - increases with increasing n. A coexistence of two lamellar phases with different D was detected by measuring the C18OH+DOPC oriented sample.

Effect of alkan-1-ols on the structure of dopc model membrane

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Effect of alkan-1-ols on the structure of dopc model membrane"}

The effect of general anaesthetics alkan-1-ols (CnOH, where n = 10, 12, 14, 16 and 18 is the number of carbon atoms in the molecule) on the structure of...

Effect of alkan-1-ols on the structure of dopc model membrane

Published Online: Nov 30, 2017

Page range: 4 - 8

Received: Jun 20, 2017

Accepted: Jul 06, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0010

Keywords
Model membrane - general anaesthetics - alkan-1-ols - small-angle neutron scattering - small-angle neutron diffraction - structure

© by T. Kondela

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Effect of alkan-1-ols on the structure of dopc model membrane

Published Online: Nov 30, 2017

Page range: 4 - 8

Received: Jun 20, 2017

Accepted: Jul 06, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0010

KeywordsModel membrane - general anaesthetics - alkan-1-ols - small-angle neutron scattering - small-angle neutron diffraction - structure

© by T. Kondela

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Model membrane - general anaesthetics - alkan-1-ols - small-angle neutron scattering - small-angle neutron diffraction - structure