<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background:</bold> Fisetin, a derivate from the flavonol group may possess a variety of pharmacological effects. The aim of the presented study was to evaluate the bronchodilatory effect of fisetin after the acute or the chronic administration to guinea pigs with allergic airway inflammation.<bold>Methods:</bold> Experimental animals were sensitized and challenged by ovalbumin. Fisetin was administered in dose 5mg/kg/p.o., either once after the end of 21-days sensitization or daily during the 21-days sensitization. By using the whole-body plethysmograph, we monitored the specific airway resistance, a parameter of airway hyperreactivity <italic>in vivo</italic>. The changes of the specific airway resistance were evaluated after the short-term inhalation of the bronchoconstriction mediator-histamine (10−6 mol.1−1).<bold>Results:</bold> Our results showed that the short-term as well as the long-term administration of fisetin caused decrease of the specific airway resistance values. The bronchodilatory effect of fisetin was comparable to the long-acting beta2 sympathomimetic – salmeterol after the long-term administration. The measurements of the bronchodilatory activity after single administration have revealed more prolonged effect of fisetin comparing to the short-acting beta2 sympathomimetic – salbutamol, as this remained even after the 5 hours, when salbutamol was already ineffective.<bold>Conclusion:</bold> In conclusion, flavonol – fisetin has shown bronchodilatory potential. In the light of this fact, fisetin may represent potential substance that can be effective in both prevention as well as control of airway inflammation symptoms.</abstract>

Background: Fisetin, a derivate from the flavonol group may possess a variety of pharmacological effects. The aim of the presented study was to evaluate the bronchodilatory effect of fisetin after the acute or the chronic administration to guinea pigs with allergic airway inflammation.Methods: Experimental animals were sensitized and challenged by ovalbumin. Fisetin was administered in dose 5mg/kg/p.o., either once after the end of 21-days sensitization or daily during the 21-days sensitization. By using the whole-body plethysmograph, we monitored the specific airway resistance, a parameter of airway hyperreactivity in vivo. The changes of the specific airway resistance were evaluated after the short-term inhalation of the bronchoconstriction mediator-histamine (10−6 mol.1−1).Results: Our results showed that the short-term as well as the long-term administration of fisetin caused decrease of the specific airway resistance values. The bronchodilatory effect of fisetin was comparable to the long-acting beta2 sympathomimetic – salmeterol after the long-term administration. The measurements of the bronchodilatory activity after single administration have revealed more prolonged effect of fisetin comparing to the short-acting beta2 sympathomimetic – salbutamol, as this remained even after the 5 hours, when salbutamol was already ineffective.Conclusion: In conclusion, flavonol – fisetin has shown bronchodilatory potential. In the light of this fact, fisetin may represent potential substance that can be effective in both prevention as well as control of airway inflammation symptoms.

The effect of short-term and long-term application of fisetin on experimentally induced airway hyperreactivity

Jessenius Faculty of Medicine in Martin, Biomedical Center Martin

Jessenius Faculty of Medicine in Martin, Department of Pharmacology

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: Fisetin, a derivate from the flavonol group may possess a variety of pharmacological effects. The aim of the presented study was to evaluate the...

The effect of short-term and long-term application of fisetin on experimentally induced airway hyperreactivity

Published Online: Nov 10, 2017

Page range: 7 - 9

Received: Feb 27, 2017

Accepted: Mar 24, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0005

Keywords
Airway hyperreactivity, fisetin, airway inflammation

© 2017 Kazimierová I. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The effect of short-term and long-term application of fisetin on experimentally induced airway hyperreactivity

Published Online: Nov 10, 2017

Page range: 7 - 9

Received: Feb 27, 2017

Accepted: Mar 24, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0005

KeywordsAirway hyperreactivity, fisetin, airway inflammation

© 2017 Kazimierová I. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Airway hyperreactivity, fisetin, airway inflammation