<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC channel, was significantly higher than in non-pregnant myometrium. Lower Orai1 protein expression did not influence the amplitude of contractile response of term-pregnant myometrium, but higher Orai1 expression observed in non-pregnant myometrium was related to the different influence of CRAC blocker on contraction frequency.</p></abstract>

The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC channel, was significantly higher than in non-pregnant myometrium. Lower Orai1 protein expression did not influence the amplitude of contractile response of term-pregnant myometrium, but higher Orai1 expression observed in non-pregnant myometrium was related to the different influence of CRAC blocker on contraction frequency.

Influence of smooth muscle contractility by inhibition of crac channels activity

Jessenius Faculty of Medicine in Martin, Biomedical Center Martin

Jessenius Faculty of Medicine in Martin, Department of Pharmacology

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Influence of smooth muscle contractility by inhibition of crac channels activity"}

The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human...

Influence of smooth muscle contractility by inhibition of crac channels activity

Published Online: Nov 10, 2017

Page range: 10 - 12

Received: Dec 14, 2016

Accepted: Jan 20, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0001

Keywords
Oral N-acetylcysteine, Inhaled N-acetylcysteine, mucus clearance, airway reactivity

© 2017 Kocmálová M. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Influence of smooth muscle contractility by inhibition of crac channels activity

Published Online: Nov 10, 2017

Page range: 10 - 12

Received: Dec 14, 2016

Accepted: Jan 20, 2017

DOI: https://doi.org/10.1515/afpuc-2017-0001

KeywordsOral N-acetylcysteine, Inhaled N-acetylcysteine, mucus clearance, airway reactivity

© 2017 Kocmálová M. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Oral N-acetylcysteine, Inhaled N-acetylcysteine, mucus clearance, airway reactivity