<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites. </p></abstract>

The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

Slovak Academy of Sciences, Biomedical Research Center, Institution of Experimental Endocrinology, Bratislava,

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of...

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

Published Online: Nov 23, 2016

Page range: 20 - 22

Received: Aug 01, 2016

Accepted: Aug 05, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0009

Keywords
Immune challenge, Kynurenine-3-monooxygenase, Gender

© by A. Csanova

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

Published Online: Nov 23, 2016

Page range: 20 - 22

Received: Aug 01, 2016

Accepted: Aug 05, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0009

KeywordsImmune challenge, Kynurenine-3-monooxygenase, Gender

© by A. Csanova

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Immune challenge, Kynurenine-3-monooxygenase, Gender