<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.</p></abstract>

Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.

A brief review on the mode of action of antinematodal drugs

Department of Biomedical Sciences, College of Veterinary Medicine

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"A brief review on the mode of action of antinematodal drugs"}

Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites....

A brief review on the mode of action of antinematodal drugs

Published Online: Jun 26, 2017

Page range: 137 - 152

Received: May 01, 2016

Accepted: May 24, 2017

DOI: https://doi.org/10.1515/acve-2017-0013

Keywords
anthelmintic, parasite, benzimidazoles, avermectins, cholinergic, emodepside, derquantel

© 2017 Abongwa Melanie et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A brief review on the mode of action of antinematodal drugs

Published Online: Jun 26, 2017

Page range: 137 - 152

Received: May 01, 2016

Accepted: May 24, 2017

DOI: https://doi.org/10.1515/acve-2017-0013

Keywordsanthelmintic, parasite, benzimidazoles, avermectins, cholinergic, emodepside, derquantel

© 2017 Abongwa Melanie et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
anthelmintic, parasite, benzimidazoles, avermectins, cholinergic, emodepside, derquantel