<abstract xmlns="http://www.w3.org/1999/xhtml">Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quantitative Insulin Sensitivity Check Index) indexes of insulin resistance with the metabolic status of cows (concentration of hormones, metabolites and body condition score). The experiment included 40 Holstein-Frisian cows in the first week after calving. Indexes of insulin resistance valued: 18.68±5.43 (HOMA), 0.39±0.06 (QUICKI) and 0.45±0.06 (RQUICKI). Linear correlations were examined by testing the coefficient of correlation (r), determination (r2,%) and regression parameter beta (b) in linear equation. A negative correlation was found between HOMA and IGF-I (insulin growth factor I) (r=−0.51, r2=25.0, b=−1.1257, p&lt;0.01). HOMA showed a positive correlation with BHB (betahidroxybutyrate) (r=0.48, r2=23.2, b=0.0234, p&lt;0.01). A positive correlation was found between QUICKI and IGF-I (r=0.30, r2=10.0 b=46.7900, p&lt;0.05) and cholesterol (r=0.44, r2=18.3, b=1.9021, p&lt;0.01). In contrast, QUICKI and BHB (r=0.51, r2=27.1, b=−1.7241, p&lt;0.01), just like QUICKI and BCS (r=0.46, r2=20.9, b=−2.424, p&lt;0.01), showed a negative correlation. RQUICKI showed positive correlations with IGF-I (r=0.48, r2=22.8, b=28.1230, p&lt;0.01), T4 (r=0.47, r2=22.1, b=87.142, p&lt;0.01) and triglycerides (r=0.36, r2=13, b=0.0407, p&lt;0.05) but negative correlations with cortisol (r=−0.36, r2=13.0, b=−9.0332, p&lt;0.05), STH (somatotropic hormone) (r=−0.42, r2=17.3, b=−5.4976, p&lt;0.01), BHB (r=−0.62, r2=38.3, b=−1.1872, p&lt;0.01), total bilirubin (r=−0.58, r2=33.7, b=−7.131, p&lt;0.01) and BCS (body condition score) (r=−0.6, r2=36.4, b=−1.8347, p&lt;0.01). In conclusion, indexes of insulin resistance may be used to evaluate the metabolic status of cows in early lactation. RQUICKI might be the most appropriate predictor of metabolic status due to its linear relationship with most of the parameters included in homeorhetic process.</abstract>

Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quantitative Insulin Sensitivity Check Index) indexes of insulin resistance with the metabolic status of cows (concentration of hormones, metabolites and body condition score). The experiment included 40 Holstein-Frisian cows in the first week after calving. Indexes of insulin resistance valued: 18.68±5.43 (HOMA), 0.39±0.06 (QUICKI) and 0.45±0.06 (RQUICKI). Linear correlations were examined by testing the coefficient of correlation (r), determination (r2,%) and regression parameter beta (b) in linear equation. A negative correlation was found between HOMA and IGF-I (insulin growth factor I) (r=−0.51, r2=25.0, b=−1.1257, p<0.01). HOMA showed a positive correlation with BHB (betahidroxybutyrate) (r=0.48, r2=23.2, b=0.0234, p<0.01). A positive correlation was found between QUICKI and IGF-I (r=0.30, r2=10.0 b=46.7900, p<0.05) and cholesterol (r=0.44, r2=18.3, b=1.9021, p<0.01). In contrast, QUICKI and BHB (r=0.51, r2=27.1, b=−1.7241, p<0.01), just like QUICKI and BCS (r=0.46, r2=20.9, b=−2.424, p<0.01), showed a negative correlation. RQUICKI showed positive correlations with IGF-I (r=0.48, r2=22.8, b=28.1230, p<0.01), T4 (r=0.47, r2=22.1, b=87.142, p<0.01) and triglycerides (r=0.36, r2=13, b=0.0407, p<0.05) but negative correlations with cortisol (r=−0.36, r2=13.0, b=−9.0332, p<0.05), STH (somatotropic hormone) (r=−0.42, r2=17.3, b=−5.4976, p<0.01), BHB (r=−0.62, r2=38.3, b=−1.1872, p<0.01), total bilirubin (r=−0.58, r2=33.7, b=−7.131, p<0.01) and BCS (body condition score) (r=−0.6, r2=36.4, b=−1.8347, p<0.01). In conclusion, indexes of insulin resistance may be used to evaluate the metabolic status of cows in early lactation. RQUICKI might be the most appropriate predictor of metabolic status due to its linear relationship with most of the parameters included in homeorhetic process.

Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation

Faculty of Agriculture, Department of Veterinary Medicine, University of Novi Sad, Trg D.Obradovića 8, 21000 Novi Sad,

Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 Beograd

Faculty of Agronomy, Department of Animal Science, University of Kragujevac, Ul.Cara Dušana 34, 32000 Čačak,

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the...

Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation

Published Online: Mar 30, 2017

Page range: 57 - 70

Received: Feb 15, 2016

Accepted: Sep 26, 2016

DOI: https://doi.org/10.1515/acve-2017-0006

Keywords
cows, insulin resistance, metabolic status, early lactation

© 2017 Cincović Marko et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation

Published Online: Mar 30, 2017

Page range: 57 - 70

Received: Feb 15, 2016

Accepted: Sep 26, 2016

DOI: https://doi.org/10.1515/acve-2017-0006

Keywordscows, insulin resistance, metabolic status, early lactation

© 2017 Cincović Marko et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
cows, insulin resistance, metabolic status, early lactation