<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological disturbances, brain metastases were suspected and the animal was euthanized. A TVT metastatic mass was found in the brain and confirmed with immunohistochemical results, being positive for vimentin and lysozyme and negative for S-100, CD3 and cytokeratin. TVT metastases in the brain are a rare event and cannot be treated with usual chemotherapy as vincristine does not cross the blood-brain barrier, thus allowing the re-emergence of the tumor after a period of time.</p></abstract>

A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological disturbances, brain metastases were suspected and the animal was euthanized. A TVT metastatic mass was found in the brain and confirmed with immunohistochemical results, being positive for vimentin and lysozyme and negative for S-100, CD3 and cytokeratin. TVT metastases in the brain are a rare event and cannot be treated with usual chemotherapy as vincristine does not cross the blood-brain barrier, thus allowing the re-emergence of the tumor after a period of time.

Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Spain

Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

METASTAZA TRANSMISIVNOG VENERIČNOG TUMORA U MOZGU PSA POSLE TRETMANA SA VINKRISTIN SULFATOM

A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it...

Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

Published Online: Mar 20, 2015

Page range: 137 - 142

Received: Sep 02, 2014

Accepted: Feb 02, 2015

DOI: https://doi.org/10.1515/acve-2015-0011

Keywords
Blood-brain barrier, brain metastases, dog, immunohistochemistry, TVT, vincristine

© PINCZOWSKI Pedro, GIMENO Marina, ACEÑA Carmen, VILLEGAS Ainara, de MARTINO Alba, LUJÁN Lluís

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

Published Online: Mar 20, 2015

Page range: 137 - 142

Received: Sep 02, 2014

Accepted: Feb 02, 2015

DOI: https://doi.org/10.1515/acve-2015-0011

KeywordsBlood-brain barrier, brain metastases, dog, immunohistochemistry, TVT, vincristine

© PINCZOWSKI Pedro, GIMENO Marina, ACEÑA Carmen, VILLEGAS Ainara, de MARTINO Alba, LUJÁN Lluís

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Blood-brain barrier, brain metastases, dog, immunohistochemistry, TVT, vincristine