<abstract xmlns="http://www.w3.org/1999/xhtml"> Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL-1 for valsartan, 8.16-28.56 mg mL-1 f or fluvastatin, 14.40-39.90 mg mL-1 for atorvastatin and 9.60-48.00 mg mL-1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.</abstract>

Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL-1 for valsartan, 8.16-28.56 mg mL-1 f or fluvastatin, 14.40-39.90 mg mL-1 for atorvastatin and 9.60-48.00 mg mL-1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The...

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Published Online: Jan 11, 2018

Page range: 463 - 478

Accepted: Jun 06, 2017

DOI: https://doi.org/10.1515/acph-2017-0031

Keywords
valsartan, atorvastatin, fluvastatin, pravastatin, derivative spectrophotometry

© by Mariusz Stolarczyk

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

Published Online: Jan 11, 2018

Page range: 463 - 478

Accepted: Jun 06, 2017

DOI: https://doi.org/10.1515/acph-2017-0031

Keywordsvalsartan, atorvastatin, fluvastatin, pravastatin, derivative spectrophotometry

© by Mariusz Stolarczyk

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
valsartan, atorvastatin, fluvastatin, pravastatin, derivative spectrophotometry