<abstract xmlns="http://www.w3.org/1999/xhtml"> The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH).</abstract>

The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH).

Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different...

Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits

Article Category: Original research paper

Published Online: Jun 01, 2017

Page range: 187 - 202

Accepted: Feb 21, 2016

DOI: https://doi.org/10.1515/acph-2017-0019

Keywords
Cornus mas, microcrystalline cellulose, direct compression, accelerated stability, principal component analysis

© by Dana Sabadková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits

Article Category: Original research paper

Published Online: Jun 01, 2017

Page range: 187 - 202

Accepted: Feb 21, 2016

DOI: https://doi.org/10.1515/acph-2017-0019

KeywordsCornus mas, microcrystalline cellulose, direct compression, accelerated stability, principal component analysis

© by Dana Sabadková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Cornus mas, microcrystalline cellulose, direct compression, accelerated stability, principal component analysis