Open Access

Determination of ramipril in human plasma and its fragmentation by UPLC-Q-TOF-MS with positive electrospray ionization


Cite

1. K. V. Gowda, U. Mandal, P. S. Selvan, W. D. S. Solomon, A. Ghosh, A. K. Sarkar, S. Agarwal, T. N. Rao and T. K. Pal, Liquid chromatography tandem mass spectrometry method for simultaneous determination of metoprolol tartrate and ramipril in human plasma, J. Chromatogr. B 858 (2007) 13-21; DOI: 10.1016/j.jchromb.2007.07.047.10.1016/j.jchromb.2007.07.047Search in Google Scholar

2. H. E. Abdellatef, M. M. Ayad and E. A. Taha, Spectrophotometric and atomic absorption spectrometric determination of ramipril and perindopril through ternary complex formation with eosin and Cu(II), J. Pharmacol. Biomed. Anal. 18 (1999) 1021-1027; DOI: 10.1016/S0731-7085(98)00113-7. 10.1016/S0731-7085(98)00113-7Search in Google Scholar

3. F. A. El Yazbi, M. E. Mahrous, H. H. Hammud, G. M. Sonji and M. N. Sonji, Comparative spectrophotometric, spectrofluorometric, and high-performance liquid chromatographic study for the quantitative determination of the binary mixture felodipine and ramipril in pharmaceutical formulations, Anal. Lett. 41 (2008) 853-870; DOI: 10.1080/00032710801934643.10.1080/00032710801934643Search in Google Scholar

4. A. S. Kamatchi, T. Vetrichelvan and D. Venkappaya, Simultaneous estimation of ramipril, acetylsalicylic acid and atorvastatin calcium by chemometrics assisted UV-spectrophotometric method in capsules, Acta Pharm. 61 (2011) 283-296; DOI: 10.2478/v10007-011-0027-1.10.2478/v10007-011-0027-121945907Search in Google Scholar

5. S. Orlandini, R. Gotti, I. Giannini, B. Pasquini and S. Furlanetto, Development of a capillary electrophoresis method for the assay of ramipril and its impurities: An issue of cis-trans isomerization, J. Chromatogr. A 1218 (2011) 2611-2617; DOI: 10.1016/j.chroma.2011.02.062.10.1016/j.chroma.2011.02.06221429497Search in Google Scholar

6. Y. T. Wu, T. M. Cham and T. R. Tsai, Development of HPLC with photo-diode array method for the determination of ramipril in tablets using factorial design, J. Chin. Chem. Soc. 61 (2014) press; DOI: 10.1002/jccs.201400130.10.1002/jccs.201400130Search in Google Scholar

7. S. Mehta, S. Singh, K. Chikhalia, P. Mehta and T. Dadhania, Determination of assay and uniformity of content of ramipril and telmisartan in their multiple dosage forms by a developed and validated supercritical fluid chromatographic technique, Anal. Methods 6 (2014) 7068-7074; DOI: 10.1039/C4AY01201A.10.1039/C4AY01201ASearch in Google Scholar

8. B .-A. Persson, C. Fakt, M. Ervik and M. Ahnoff , Interference from a glucuronide metabolite in the determination of ramipril and ramiprilat in human plasma and urine by gas chromatography- mass spectrometry, J. Pharmacol. Biomed. Anal. 40 (2006) 794-798; DOI: 10.1016/j.jpba.2005.08.013.10.1016/j.jpba.2005.08.01316242284Search in Google Scholar

9. A . Tan, W. Jin, F. Deng, S. Hussain, A. Musuku and R. Masse, Bioanalytical method development and validation using incurred samples - simultaneous quantitation of ramipril and ramiprilat in human EDTA plasma by LC-MS/MS, J. Chromatogr. B 877 (2009) 3673-3680; DOI: 10.1016/j. jchromb.2009.09.017.Search in Google Scholar

10. V . K. Gupta, R. Jain, O. Lukram, S. Agarwal and A. Dwivedi, Simultaneous determination of ramipril, ramiprilat and telmisartan in human plasma using liquid chromatography tandem mass spectrometry, Talanta 83 (2011) 709-716; DOI: 10.1016/j.talanta.2010.10.011.10.1016/j.talanta.2010.10.01121147310Search in Google Scholar

11. R . Varga, Z. Eke and K. Torkos, Identification of phase I metabolites of cardiovascular and antiulcer drugs in surface water samples with liquid-chromatography-mass spectrometry methods, Talanta 85 (2011) 1920-1926; DOI: 10.1016/j.talanta.2011.07.020.10.1016/j.talanta.2011.07.02021872039Search in Google Scholar

12. O. Gonzales, R. M. Alonso, N. Ferreirόs, W. Weinmann, R. Zimmermann and S. Dresen, Development of an LC-MS/MS method for the quantitation of 55 compounds prescribed in combined cardiovascular therapy, J. Chromatogr. B 879 (2011) 243-252; DOI: 10.1016/j.jchromb.2010.12.007.10.1016/j.jchromb.2010.12.007Search in Google Scholar

13. D. S . Jain, G. Subbaiah, M. Sanyal, U. C. Pande and P. Shrivastav, First LC-MS/MS electrospray ionization validated method for the quantification of perindopril and its metabolite perindoprilat in human plasma and its application to bioequivalence study, J. Chromatogr. B 837 (2006) 92-100; DOI: 10.1016/j.jchromb.2006.04.008.10.1016/j.jchromb.2006.04.008Search in Google Scholar

14. J. R. Patel, T. M. Pethani, A. N. Vachhani, N. R. Sheth and A. V. Dudhrejiya, Development and validation of bioanalytical method for simultaneous estimation of ramipril and hydrochlorothia zide in human plasma using liquid chromatography-tandem mass spectrometry, J. Chromatogr. B 970 (2014) 53-59; DOI: 10.1016/j.jchromb.2014.08.023.10.1016/j.jchromb.2014.08.023Search in Google Scholar

15. B. Yuan, X. Wang, F. Zhang, J. Jia and F. Tang, Simultaneous determination of ramipril and active metabolite ramiprilat in human plasma by LC-MS-MS, Chromatographia 68 (2008) 533-539; DOI: 10.1365/s10337-008-0757-5.10.1365/s10337-008-0757-5Search in Google Scholar

16. Z. Z hu, A. Vachareau and L. Neirinck, Liquid chromatography-mass spectrometry method for determination of ramipril and its active metabolite ramiprilat in human plasma, J. Chromatogr. B 779 (2002) 297-306.10.1016/S1570-0232(02)00398-7Search in Google Scholar

17. X.-Y. Lu, J.-Z. Shen-Tu and J. Liu, High-performance liquid chromatography-mass spectrometric analysis of ramipril and its active metabolite ramiprilat in human serum: Application to a pharmacokinetic study in the Chinese volunteers, J. Pharmacol. Biomed. Anal. 40 (2006) 478-483; DOI: 10.1016/j.jpba.2005.07.054.10.1016/j.jpba.2005.07.05416181761Search in Google Scholar

18. S. B roecker, F. Pragst, A. Bakdash, S. Herre and M. Tsokos, Combined use of liquid chromatography- hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) and high performance liquid chromatography with photodiode array detector (HPLC-DAD) in systematic toxicological analysis, Forensic Sci. Int. 212 (2011) 215-226; DOI: 10.1016/j.forsciint.2011.06.014.10.1016/j.forsciint.2011.06.01421764531Search in Google Scholar

19. R. N . Tiwari and C. G. Bonde, LC, LC-MS/TOF and MSn studies for the identification and characterization of degradation products of nelfinavir mesylate, J. Pharmacol. Biomed. Anal. 55 (2011) 435-445; DOI: 10.1016/j.jpba.2011.02.020.10.1016/j.jpba.2011.02.02021392920Search in Google Scholar

20. B. Ra ju, M. Ramesh, R. Srinivas, S. S. Raju and Y. Venkateswarlu, Identification and characterization of stressed degradation products of prulifloxacin using LC-ESI-MS/Q-TOF, MSn experiments: Development of a validated specific stability-indicating LC-MS method, J. Pharmacol. Biomed. Anal. 56 (2011) 560-568; DOI: 10.1016/j.jpba.2011.06.021.10.1016/j.jpba.2011.06.02121783336Search in Google Scholar

21. V. Ku mar, S. Malik and S. Singh, Polypill for the treatment of cardiovascular diseases: Part 2. LC-MS/TOF characterization of interaction/degradation products of atenolol/lisinopril and aspirin, and mechanisms of formation thereof, J. Pharmacol. Biomed. Anal. 48 (2008) 619-628; DOI: 10.1016/j.jpba.2008.06.003.10.1016/j.jpba.2008.06.00318635333Search in Google Scholar

22. R. Sk ibiński, A study of photodegradation of quetiapine by the use of LC-MS/MS method, Cent. Eur. J. Chem. 10 (2012) 232-240; DOI: 10.2478/s11532-011-0133-4.10.2478/s11532-011-0133-4Search in Google Scholar

23. P. Szp ot, K. Bańka, G. Buszewicz and R. Mądro, Determination of imazalil and thiabendazole by UPLC-Q-TOF-MS - an analysis of a grapefruit extract-containing dietary supplement, Curr. Issues Pharm. Med. Sci. 25 (2012) 401-403; DOI: 10.12923/j.2084-980X/25.4/a.13.10.12923/j.2084-980X/25.4/a.13Search in Google Scholar

24. Y. Pico, M. la Ferre, C. Soler and D. Barcelo, Identification of unknown pesticides in fruits using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry: Imazalil as a case study of quantification, J. Chromatogr. A 1176 (2007) 123-134; DOI: 10.1016/j.chroma. 2007.10.071.Search in Google Scholar

25. M. Dendeni, N. Cimetiere, A. Amrane and N. Ben Hamida, Impurity profiling of trandolapril under stress testing structure elucidation of by-products and development of degradation pathway, Int. J. Pharm. 438 (2012) 61-70; DOI: 10.1016/j.ij pharm.2012.08.048.Search in Google Scholar

26. R. Dubey and M. Ghosh, Simultaneous determination and pharmacokinetic study of losartan, losartan carboxylic, ramipril, ramiprilat and hydrochlorothiazide in rat plasma by liquid chromatography/ tandem mass spectrometry method, Sci. Pharm. (2014) in press; DOI: 10.3797/scipharm. 1410-15.Search in Google Scholar

eISSN:
1846-9558
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Pharmacy, other